{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,11]],"date-time":"2026-02-11T13:59:02Z","timestamp":1770818342257,"version":"3.50.1"},"reference-count":12,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2025,11,25]],"date-time":"2025-11-25T00:00:00Z","timestamp":1764028800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2025,11,25]],"date-time":"2025-11-25T00:00:00Z","timestamp":1764028800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Transplant Infectious Dis"],"published-print":{"date-parts":[[2026,1]]},"abstract":"ABSTRACT<\/jats:title>\n \n Background<\/jats:title>\n Solid organ transplant (SOT) recipients are vulnerable to infections with multidrug\u2010resistant organisms, and they often do not receive adequate empiric\u00a0antimicrobials\u00a0for serious Gram\u2010negative infections. Knowledge of differences in antimicrobial resistance rates in this specific population can help guide empiric antimicrobial choices.<\/jats:p>\n <\/jats:sec>\n \n Methods<\/jats:title>\n We performed a retrospective cohort study comparing antimicrobial susceptibility patterns of Gram\u2010negative organisms isolated from the adult SOT recipients with documented sepsis with the hospital\u2010wide inpatient antibiogram. To evaluate empiric antimicrobial coverage, we constructed a Weighted\u2010Incidence Syndromic Combination Antibiogram (WISCA) by calculating the proportion of susceptible isolates per antimicrobial agent. We then compared the coverage rates against our institution's sepsis treatment guidelines.<\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n \n A total of 90 Gram\u2010negative isolates comprised the SOT cohort, while the inpatient antibiogram cohort had 1328 isolates.\n Pseudomonas aeruginosa<\/jats:italic>\n (27%) and\n Escherichia coli<\/jats:italic>\n (31%) were the most common isolates in the SOT and inpatient antibiogram cohorts, respectively. Overall, antimicrobial resistance rates were higher in the SOT population compared to the hospital\u2010wide inpatient antibiogram population. WISCA analysis showed imipenem was active\u00a0for 59% of isolates as opposed to the institutional recommendation of piperacillin\u2013tazobactam, which covered 39% of SOT\u00a0isolates.\n <\/jats:p>\n <\/jats:sec>\n \n Conclusion<\/jats:title>\n Current empiric antimicrobial recommendations for SOT patients are based on data from the general patient population, which may not accurately reflect the resistance patterns in this unique population. Utilizing patient population\u2010specific antibiograms may improve empiric antimicrobial therapy and warrants further research.<\/jats:p>\n <\/jats:sec>","DOI":"10.1111\/tid.70136","type":"journal-article","created":{"date-parts":[[2025,11,25]],"date-time":"2025-11-25T14:07:56Z","timestamp":1764079676000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["A Comparison of a Solid Organ Transplant Population\u2010Specific Antibiogram With the Hospital\u2010Wide Antibiogram"],"prefix":"10.1111","volume":"28","author":[{"given":"Arzina","family":"Aziz Ali","sequence":"first","affiliation":[{"name":"University of Illinois at Chicago College of Medicine Chicago Illinois USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Scott","family":"Borgetti","sequence":"additional","affiliation":[{"name":"University of Illinois at Chicago College of Medicine Chicago Illinois USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alan E.","family":"Gross","sequence":"additional","affiliation":[{"name":"University of Illinois at Chicago College of Medicine Chicago Illinois USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alfredo J.","family":"Mena Lora","sequence":"additional","affiliation":[{"name":"University of Illinois at Chicago College of Medicine Chicago Illinois USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ryan","family":"Knodle","sequence":"additional","affiliation":[{"name":"University of Illinois at Chicago College of Medicine Chicago Illinois USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Taha","family":"Ali","sequence":"additional","affiliation":[{"name":"Northwest Suburban Medical Associates Arlington Heights Illinois USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nahed","family":"Ismail","sequence":"additional","affiliation":[{"name":"University of Illinois at Chicago College of Medicine Chicago Illinois USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2025,11,25]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-3-030-25869-6_8"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1093\/ofid\/ofae060"},{"key":"e_1_2_8_4_1","unstructured":"\u201cAntimicrobial Resistance \u201dWHO published November 21 2023 https:\/\/www.who.int\/news\u2010room\/fact\u2010sheets\/detail\/antimicrobial\u2010resistance#:~:text=Key%20facts income%20countries%20are%20most%20affected."},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/ciae403"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/ctr.13594"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600\u20106143.2009.02664.x"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/ajt.12093"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.diagmicrobio.2016.08.018"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmi.2022.06.005"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1097\/QCO.0000000000000848"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jgar.2017.08.009"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1086\/664768"}],"container-title":["Transplant Infectious 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