{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,11]],"date-time":"2026-04-11T22:52:34Z","timestamp":1775947954405,"version":"3.50.1"},"reference-count":27,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2026,2,5]],"date-time":"2026-02-05T00:00:00Z","timestamp":1770249600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2026,2,5]],"date-time":"2026-02-05T00:00:00Z","timestamp":1770249600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Transplant Infectious Dis"],"published-print":{"date-parts":[[2026,3]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:label\/>\n                    <jats:p>The COVID\u201019 pandemic exposed the vulnerability of immunocompromised hosts and the scarcity of evidence guiding their management. Within the European Horizon 2020 ORCHESTRA project, a multinational consortium connected existing and new cohorts to harmonize data, laboratory methods, and clinical expertise across fragile populations. The fragile patients\u2019 cohort became a model for how collaborative infrastructure can generate actionable evidence during a crisis. Through prospective follow\u2010up and centralized immunologic assessment, ORCHESTRA defined the clinical spectrum of COVID\u201019 in transplant recipients, identified vaccine\u2010modified disease phenotypes, and clarified the kinetics and correlates of immune protection. The project also demonstrated the feasibility of real\u2010time immunologic monitoring, the value of data interoperability, and the need for adaptive harmonization across health systems. Integrating these results through Delphi consensus, ORCHESTRA translated research into practice, providing pragmatic guidance for clinicians across Europe. This experience underscores that harmonized, multidisciplinary research\u2014rooted in collaboration and flexibility\u2014can transform variability into knowledge and ultimately improve care for the most immunologically fragile patients.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/tid.70145","type":"journal-article","created":{"date-parts":[[2026,2,6]],"date-time":"2026-02-06T07:44:49Z","timestamp":1770363889000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Pan\u2010European Fragile Populations Cohort for COVID\u201019: What Worked, What Didn't, and Lessons Learned"],"prefix":"10.1111","volume":"28","author":[{"given":"Beatrice","family":"Tazza","sequence":"first","affiliation":[{"name":"Infectious Diseases Unit Department for Integrated Infectious Risk Management IRCCS Azienda Ospedaliero\u2010Universitaria di Bologna  Bologna 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