{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,11]],"date-time":"2026-04-11T22:52:32Z","timestamp":1775947952456,"version":"3.50.1"},"reference-count":19,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2026,1,30]],"date-time":"2026-01-30T00:00:00Z","timestamp":1769731200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2026,1,30]],"date-time":"2026-01-30T00:00:00Z","timestamp":1769731200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Transplant Infectious Dis"],"published-print":{"date-parts":[[2026,3]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>A 4\u2010month course of rifampin is one of the recommended first\u2010line regimens for latent tuberculosis infection (LTBI). However, data on its use among kidney transplant candidates (KTC) remain limited.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We conducted a retrospective study of all KTC treated with either 4\u2010month rifampin or 9\u2010month isoniazid (INH) for LTBI at a transplant infectious disease clinic in Miami from January 1, 2021 to December 31, 2024. We assessed rates of treatment completion, adverse reactions leading to discontinuation of therapy, and transaminase elevation (&gt;\u00a02 times the upper limit of normal). The potential impact of rifampin on blood pressure (BP) in patients on antihypertensive drugs (AHD) known to interact with rifampin was also evaluated.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      A total of 66 patients were analyzed (49 [74%] in the INH group and 17 [26%] in the rifampin group). There was a trend towards higher treatment completion in the rifampin group compared to the INH group (16 [94%] vs. 34 [69%],\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0=\u00a00.05). There was no difference in adverse reactions leading to treatment discontinuation. Transaminase elevations were not observed in the rifampin group, whereas they occurred in 3 (6%) of the INH group. Three patients experienced an increase in BP while receiving rifampin, leading to treatment discontinuation in one case.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>A 4\u2010month rifampin course is an excellent option for LTBI among KTC due to its high completion rate and favorable liver safety profile; however, close monitoring for AHD interactions is essential.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/tid.70169","type":"journal-article","created":{"date-parts":[[2026,1,30]],"date-time":"2026-01-30T14:49:39Z","timestamp":1769784579000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Comparison of Rifampin and Isoniazid for Latent Tuberculosis Infection in Kidney Transplant Candidates: Focus on Tolerability and Treatment Completion"],"prefix":"10.1111","volume":"28","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9626-0760","authenticated-orcid":false,"given":"Jacques","family":"Simkins","sequence":"first","affiliation":[{"name":"Department of Medicine\/Division of Infectious Diseases University of Miami School of Medicine  Miami Florida USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8145-9440","authenticated-orcid":false,"given":"Julia Bini","family":"Viotti","sequence":"additional","affiliation":[{"name":"Department of Medicine\/Division of Infectious Diseases University of Miami School of Medicine  Miami Florida USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yoichiro","family":"Natori","sequence":"additional","affiliation":[{"name":"Department of Medicine\/Division of Infectious Diseases University of Miami School of Medicine  Miami Florida USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shweta","family":"Anjan","sequence":"additional","affiliation":[{"name":"Department of Medicine\/Division of Infectious Diseases University of Miami School of Medicine  Miami Florida USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Adela","family":"Mattiazzi","sequence":"additional","affiliation":[{"name":"Department of Medicine\/Katz Family Division of Nephrology and Hypertension University of Miami School of Medicine  Miami Florida USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mariella","family":"Ortigosa\u2010Goggins","sequence":"additional","affiliation":[{"name":"Department of Medicine\/Katz Family Division of Nephrology and Hypertension University of Miami School of Medicine  Miami Florida USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Giselle","family":"Guerra","sequence":"additional","affiliation":[{"name":"Department of Medicine\/Katz Family Division of Nephrology and Hypertension University of Miami School of Medicine  Miami Florida USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David","family":"Roth","sequence":"additional","affiliation":[{"name":"Department of Medicine\/Katz Family Division of Nephrology and Hypertension University of Miami School of Medicine  Miami Florida USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Warren","family":"Kupin","sequence":"additional","affiliation":[{"name":"Department of Medicine\/Katz Family Division of Nephrology and Hypertension University of Miami School of Medicine  Miami Florida USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Javier A.","family":"Pagan","sequence":"additional","affiliation":[{"name":"Department of Medicine\/Katz Family Division of Nephrology and Hypertension University of Miami School of Medicine  Miami Florida USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Franco","family":"Cabeza","sequence":"additional","affiliation":[{"name":"Department of Medicine\/Katz Family Division of Nephrology and Hypertension University of Miami School of Medicine  Miami Florida USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0269-4152","authenticated-orcid":false,"given":"Gaetano","family":"Ciancio","sequence":"additional","affiliation":[{"name":"Department of Surgery University of Miami School of Medicine  Miami Florida USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7236-6966","authenticated-orcid":false,"given":"Mahmoud","family":"Morsi","sequence":"additional","affiliation":[{"name":"Department of Surgery University of Miami School of Medicine  Miami Florida USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michele I.","family":"Morris","sequence":"additional","affiliation":[{"name":"Department of Medicine\/Division of Infectious Diseases University of Miami School of Medicine  Miami Florida USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2026,1,30]]},"reference":[{"key":"e_1_2_8_2_1","volume-title":"Tuberculosis: Data and 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