{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,11]],"date-time":"2026-04-11T22:52:47Z","timestamp":1775947967344,"version":"3.50.1"},"reference-count":38,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2026,1,19]],"date-time":"2026-01-19T00:00:00Z","timestamp":1768780800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,1,19]],"date-time":"2026-01-19T00:00:00Z","timestamp":1768780800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/100011542","name":"Center for Clinical and Translational Science, Mayo Clinic","doi-asserted-by":"publisher","award":["UL1TR002377"],"award-info":[{"award-number":["UL1TR002377"]}],"id":[{"id":"10.13039\/100011542","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Transplant Infectious Dis"],"published-print":{"date-parts":[[2026,3]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>\n                      Solid organ transplant (SOT) recipients are at risk for\n                      <jats:italic>Pneumocystis<\/jats:italic>\n                      <jats:italic>jirovecii<\/jats:italic>\n                      pneumonia (PCP), yet how their clinical phenotype and outcomes compare with other immunocompromised patients without HIV remains poorly defined.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We conducted a multicenter retrospective cohort study of adults with proven or probable PCP from 2017 to 2025, including 95 SOT recipients and 588 non\u2010SOT, non\u2010HIV immunocompromised patients. The primary outcome was 90\u2010day mortality, secondary outcomes included new renal failure requiring dialysis, and 30\u2010day mortality. Outcomes were analyzed using inverse probability weighting (IPW) with winsorization to adjust for baseline differences.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      In unadjusted analysis, SOT recipients had lower 90\u2010day mortality (hazard ratio [HR]: 0.62, 95% CI 0.39\u20130.97,\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0=\u00a00.037). After IPW with winsorization of extreme weights, SOT status remained associated with lower 90\u2010day mortality (HR: 0.32, 95% CI 0.13\u20130.76,\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0=\u00a00.009), and 30\u2010day mortality (HR: 0.35, 95% CI: 0.14\u20130.92,\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0=\u00a00.034). SOT recipients had higher odds of renal failure requiring dialysis in unadjusted analysis (OR: 3.49, 95% CI 1.94\u20136.14,\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0&lt;\u00a00.001), which persisted after IPW adjustment (OR: 1.62, 95% CI: 1.04\u20132.51,\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0=\u00a00.032).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Despite higher rates of renal failure requiring dialysis, SOT recipients with PCP experienced significantly improved short\u2010 and intermediate\u2010term survival compared with other non\u2010HIV immunocompromised patients, underscoring the need for further investigation into transplant\u2010associated contributors to PCP outcomes.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/tid.70171","type":"journal-article","created":{"date-parts":[[2026,1,19]],"date-time":"2026-01-19T18:06:32Z","timestamp":1768845992000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Clinical Characteristics and Outcomes of\n                    <i>Pneumocystis<\/i>\n                    Pneumonia in Solid Organ Transplant Recipients"],"prefix":"10.1111","volume":"28","author":[{"ORCID":"https:\/\/orcid.org\/0009-0000-8225-1361","authenticated-orcid":false,"given":"Aaron M.","family":"Pulsipher","sequence":"first","affiliation":[{"name":"Department of Critical Care, Mayo Clinic  Phoenix Arizona USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Emily","family":"Thompson","sequence":"additional","affiliation":[{"name":"Division of Clinical Trials and Biostatistics Mayo Clinic  Phoenix Arizona USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6391-0349","authenticated-orcid":false,"given":"Holenarasipur R.","family":"Vikram","sequence":"additional","affiliation":[{"name":"Division of Infectious Diseases and Transplant Center Mayo Clinic  Phoenix Arizona USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael B.","family":"Gotway","sequence":"additional","affiliation":[{"name":"Division of Cardiothoracic Radiology Mayo Clinic  Phoenix Arizona USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rodrigo","family":"Cartin\u2010Ceba","sequence":"additional","affiliation":[{"name":"Department of Critical Care, Mayo Clinic  Phoenix Arizona USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andrew H.","family":"Limper","sequence":"additional","affiliation":[{"name":"Division of Pulmonary and Critical Care Mayo Clinic  Rochester Minnesota 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