{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T12:35:58Z","timestamp":1790858158972,"version":"4.1.0"},"reference-count":15,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2026,1,26]],"date-time":"2026-01-26T00:00:00Z","timestamp":1769385600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,1,26]],"date-time":"2026-01-26T00:00:00Z","timestamp":1769385600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Transplant Infectious Dis"],"published-print":{"date-parts":[[2026,5]]},"abstract":"ABSTRACT<\/jats:title>\n \n Background<\/jats:title>\n Parvovirus B19 (PVB19) is a clinically important cause of refractory anemia in kidney transplant recipients (KTRs). Data from low\u2010 and middle\u2010income settings remain scarce despite high transplant volumes. This study evaluated the clinical spectrum, management practices, and outcomes of PVB19 infection across major transplant programs in India.<\/jats:p>\n <\/jats:sec>\n \n Methods<\/jats:title>\n We conducted a retrospective multicenter cohort study across 14 tertiary transplant centers. All KTRs with PCR\u2010confirmed PVB19 infection and complete clinical data were included. Clinical features, bone marrow findings, immunosuppressive (IS) adjustments, intravenous immunoglobulin (IVIG) use, and patient and graft outcomes were analyzed.<\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n \n A total of 135 KTRs were identified. Median time to infection was 11 weeks posttransplant. Anemia was universal, not frequently accompanied by leukopenia (17.7%) or thrombocytopenia (14.8%). Bone marrow examinations (\n n<\/jats:italic>\n \u00a0=\u00a034) demonstrated giant proerythroblasts or pure red cell aplasia. IS reduction was implemented in all patients; most commonly, complete MMF withdrawal (61.5%). IVIG was administered to 90% (median cumulative dose 100\u00a0g). Overall, 97% achieved hematologic recovery, with a median response time of 20 days. Recurrence occurred in 4.4%. At a median follow\u2010up of 18 months, graft survival was 92.6%; graft loss (\n n<\/jats:italic>\n \u00a0=\u00a010) was primarily due to antibody\u2010mediated rejection, and no deaths were attributable to PVB19.\n <\/jats:p>\n <\/jats:sec>\n \n Conclusions<\/jats:title>\n PVB19 infection represents an important consideration in the differential diagnosis of early posttransplant anemia in KTRs. Timely PCR testing and pragmatic treatment strategies can achieve favorable hematologic and graft outcomes in resource\u2010constrained settings.<\/jats:p>\n <\/jats:sec>","DOI":"10.1111\/tid.70174","type":"journal-article","created":{"date-parts":[[2026,1,26]],"date-time":"2026-01-26T10:57:41Z","timestamp":1769425061000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Parvovirus B19 Infection in Kidney Transplant Recipients: Clinical Spectrum, Management, and Outcomes in a Large Multicentered Indian Cohort"],"prefix":"10.1111","volume":"28","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6073-8101","authenticated-orcid":false,"given":"Priti","family":"Meena","sequence":"first","affiliation":[{"name":"Department of Nephrology All India Institute of Medical Sciences Bhubaneswar Odisha India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4788-3368","authenticated-orcid":false,"given":"Vijaychander","family":"Bukka","sequence":"additional","affiliation":[{"name":"Department of Nephrology Nizam's Institute of Medical Sciences Hyderabad Telangana India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vinant","family":"Bhargava","sequence":"additional","affiliation":[{"name":"Department of Nephrology Sir Ganga Ram Hospital New Delhi India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vivek","family":"Pathak","sequence":"additional","affiliation":[{"name":"Department of Nephrology Kovai Kidney Center Coimbatore Tamil Nadu India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Umapati","family":"Hegde","sequence":"additional","affiliation":[{"name":"Muljibhai Patel Urological Hospital (MPUH) Nadiad Gujarat India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8379-6395","authenticated-orcid":false,"given":"Vishal","family":"Singh","sequence":"additional","affiliation":[{"name":"Army Hospital (R&R) New Delhi India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9533-3462","authenticated-orcid":false,"given":"Ashay","family":"Shingare","sequence":"additional","affiliation":[{"name":"Department of Nephrology Jaslok Hospital and Research Center Mumbai Maharashtra India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1707-5650","authenticated-orcid":false,"given":"Sanjiv","family":"Jasuja","sequence":"additional","affiliation":[{"name":"Deparment of Nephrology Indraprastha Apollo Hospital New Delhi India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vishwanath","family":"Siddini","sequence":"additional","affiliation":[{"name":"Department of Nephrology Manipal Hospital Bengaluru Karnataka India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Swarnalatha","family":"Guditi","sequence":"additional","affiliation":[{"name":"Department of Nephrology Nizam's Institute of Medical Sciences Hyderabad Telangana India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anil","family":"Bhalla","sequence":"additional","affiliation":[{"name":"Department of Nephrology Sir Ganga Ram Hospital New Delhi India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sandip","family":"Panda","sequence":"additional","affiliation":[{"name":"Department of Nephrology All India Institute of Medical Sciences Bhubaneswar Odisha India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M. Edwin","family":"Fernando","sequence":"additional","affiliation":[{"name":"Department of Nephrology Government Stanley Medical College Chennai Tamil Nadu India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arvind","family":"Canchi","sequence":"additional","affiliation":[{"name":"Department of Nephrology Trustwell Hospitals Pvt. Ltd. Bengaluru Karnataka India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dinesh Kumar","family":"Thanikachalam","sequence":"additional","affiliation":[{"name":"Department of Nephrology Madras Medical College Chennai Tamil Nadu India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Umesh","family":"Godhani","sequence":"additional","affiliation":[{"name":"Department of Nephrology Kidney Cure Clinic & Dialysis Center Ahmedabad India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rajat","family":"Grover","sequence":"additional","affiliation":[{"name":"Department of Nephrology Sir Ganga Ram Hospital New Delhi India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Prity Rai","family":"Kumari","sequence":"additional","affiliation":[{"name":"Department of Nephrology All India Institute of Medical Sciences Bhubaneswar Odisha India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M. M.","family":"Bahadur","sequence":"additional","affiliation":[{"name":"Department of Nephrology Jaslok Hospital and Research Center Mumbai Maharashtra India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Priyash","family":"Tambi","sequence":"additional","affiliation":[{"name":"Department of Nephrology Institute of Kidney Diseases and Research Center and Dr. H L Trivedi Institute of Transplantation Sciences (IKDRC\u2010ITS) Ahmedabad Gujarat India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vivek","family":"Kute","sequence":"additional","affiliation":[{"name":"Department of Nephrology Institute of Kidney Diseases and Research Center and Dr. H L Trivedi Institute of Transplantation Sciences (IKDRC\u2010ITS) Ahmedabad Gujarat India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,1,26]]},"reference":[{"issue":"11","key":"e_1_2_10_2_1","first-page":"1815","article-title":"Association of Anemia With Mortality in Kidney Transplant Recipients","volume":"12","author":"Molnar M. 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