{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,12]],"date-time":"2026-09-12T10:12:18Z","timestamp":1789207938825,"version":"build-2803163510"},"reference-count":21,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2026,2,25]],"date-time":"2026-02-25T00:00:00Z","timestamp":1771977600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,2,25]],"date-time":"2026-02-25T00:00:00Z","timestamp":1771977600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Transplant Infectious Dis"],"published-print":{"date-parts":[[2026,5]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>CD19\u2010directed chimeric antigen receptor (CAR) T\u2010cell therapy has exhibited efficacy in treating relapsed\/refractory high\u2010grade B\u2010cell malignancies, but off\u2010tumor effects cause prolonged hypogammaglobulinemia and B\u2010cell aplasia. Limited data exist on pathogen\u2010specific IgG titers post\u2010CD19 CAR T\u2010cell therapy.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      We evaluated the impact of CD19 CAR T\u2010cell therapy on vaccine\u2010preventable infectious disease IgG titers in 20 patients to assess humoral immunity. IgG titers for measles virus (MeV), mumps virus (MuV), rubella virus (RuV), varicella zoster virus (VZV), pneumococcal capsular polysaccharide,\n                      <jats:italic>Haemophilus influenzae type B<\/jats:italic>\n                      (Hib), and tetanus toxoid were measured at baseline and Day 100 post\u2010CD19 CAR T\u2010cell therapy.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Seropositivity for all pathogens remained stable from baseline to Day 100. Quantitative IgG titers for MeV, MuV, RuV, VZV, and tetanus also remained stable. Median pneumococcal IgG and Hib IgG titers declined (\n                      <jats:italic>p\u00a0<\/jats:italic>\n                      &lt;\u00a00.05); however, no arbitrary fourfold decreases were observed. Median total IgG concentrations declined (\n                      <jats:italic>p\u00a0<\/jats:italic>\n                      &lt;\u00a00.05).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>MeV, MuV, RuV, VZV, and tetanus toxoid IgG remained stable following CD19 CAR T\u2010cell therapy, while pneumococcal and Hib IgG titers showed marginal quantitative declines, without any fourfold reductions. Overall, humoral immunity at Day 100 following CD19 CAR T\u2010cell therapy remained largely preserved. These seroprevalence findings suggest that routine revaccination may not be required in our patient cohort and highlight the importance of patient monitoring to inform revaccination decisions.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/tid.70188","type":"journal-article","created":{"date-parts":[[2026,3,8]],"date-time":"2026-03-08T09:43:44Z","timestamp":1772963024000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Impact of CD19 CAR T\u2010Cell Therapy on Pathogen\u2010Specific Antibody Titers in Lymphoma Patients"],"prefix":"10.1111","volume":"28","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7837-5991","authenticated-orcid":false,"given":"Hayley","family":"Foy\u2010Stones","sequence":"first","affiliation":[{"name":"Cryobiology Laboratory Stem Cell Facility St. James's Hospital  Dublin Ireland"},{"name":"Trinity Translational Medicine Institute Trinity College  Dublin Ireland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0007-3064-0227","authenticated-orcid":false,"given":"Nicola","family":"Gardiner","sequence":"additional","affiliation":[{"name":"Cryobiology Laboratory Stem Cell Facility St. James's Hospital  Dublin Ireland"},{"name":"National Adult Stem Cell Transplant and Adult CAR T\u2010Cell Programme, Haematology, St. James's Hospital  Dublin Ireland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ellen","family":"Walsh","sequence":"additional","affiliation":[{"name":"Trinity Translational Medicine Institute Trinity College  Dublin Ireland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Derek G.","family":"Doherty","sequence":"additional","affiliation":[{"name":"Trinity Translational Medicine Institute Trinity College  Dublin Ireland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anthony M.","family":"McElligott","sequence":"additional","affiliation":[{"name":"Trinity Translational Medicine Institute Trinity College  Dublin Ireland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chris","family":"Armstrong","sequence":"additional","affiliation":[{"name":"National Adult Stem Cell Transplant and Adult CAR T\u2010Cell Programme, Haematology, St. James's Hospital  Dublin Ireland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7203-7580","authenticated-orcid":false,"given":"Nina","family":"Orfali","sequence":"additional","affiliation":[{"name":"National Adult Stem Cell Transplant and Adult CAR T\u2010Cell Programme, Haematology, St. James's Hospital  Dublin Ireland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert","family":"Henderson","sequence":"additional","affiliation":[{"name":"National Adult Stem Cell Transplant and Adult CAR T\u2010Cell Programme, Haematology, St. James's Hospital  Dublin Ireland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elisabeth","family":"Vandenberghe","sequence":"additional","affiliation":[{"name":"National Adult Stem Cell Transplant and Adult CAR T\u2010Cell Programme, Haematology, St. James's Hospital  Dublin Ireland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elizabeth","family":"Higgins","sequence":"additional","affiliation":[{"name":"National Adult Stem Cell Transplant and Adult CAR T\u2010Cell Programme, Haematology, St. James's Hospital  Dublin Ireland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tor","family":"Hervig","sequence":"additional","affiliation":[{"name":"Irish Blood Transfusion Service  Dublin Ireland"},{"name":"Department of Clinical Science University of Bergen  Bergen Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5048-5021","authenticated-orcid":false,"given":"Allison","family":"Waters","sequence":"additional","affiliation":[{"name":"Irish Blood Transfusion Service  Dublin Ireland"},{"name":"UCD School of Public Health, Physiotherapy and Sports Science University College Dublin  Dublin Ireland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brendan","family":"Crowley","sequence":"additional","affiliation":[{"name":"Virology St. James's Hospital  Dublin Ireland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elizabeth","family":"Groarke","sequence":"additional","affiliation":[{"name":"Immunology Department St. James's Hospital  Dublin Ireland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Niall P.","family":"Conlon","sequence":"additional","affiliation":[{"name":"Immunology Department St. James's Hospital  Dublin Ireland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christopher L.","family":"Bacon","sequence":"additional","affiliation":[{"name":"National Adult Stem Cell Transplant and Adult CAR T\u2010Cell Programme, Haematology, St. James's Hospital  Dublin Ireland"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,2,25]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41571\u2010023\u201000754\u20101"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1707447"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1804980"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41591\u2010021\u201001622\u20100"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/s1470\u20102045(21)00591\u2010x"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/tid.14109"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1182\/bloodadvances.2019000952"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood\u20102016\u201001\u2010694356"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1172\/jci.insight.146743"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.annonc.2021.12.003"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood\u20102021\u2010153500"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jtct.2024.02.003"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1111\/bjh.19807"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1182\/bloodadvances.2020002732"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jtct.2024.07.018"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1007\/978\u20101\u20100716\u20103056\u20103_10"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.vaccine.2019.11.067"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood\u20102021\u2010153500"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.3390\/vaccines12091070"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.1182\/hem.V18.5.202154"},{"key":"e_1_2_8_22_1","doi-asserted-by":"publisher","DOI":"10.1080\/17474086.2022.2063833"}],"container-title":["Transplant 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Disease"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/tid.70188","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/tid.70188","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/tid.70188","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,9,12]],"date-time":"2026-09-12T09:56:32Z","timestamp":1789206992000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/tid.70188"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,2,25]]},"references-count":21,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2026,5]]}},"alternative-id":["10.1111\/tid.70188"],"URL":"https:\/\/doi.org\/10.1111\/tid.70188","archive":["Portico"],"relation":{},"ISSN":["1398-2273","1399-3062"],"issn-type":[{"value":"1398-2273","type":"print"},{"value":"1399-3062","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,2,25]]},"assertion":[{"value":"2025-12-03","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication 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