{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,12]],"date-time":"2026-09-12T10:11:29Z","timestamp":1789207889914,"version":"build-2803163510"},"reference-count":52,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2026,2,25]],"date-time":"2026-02-25T00:00:00Z","timestamp":1771977600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,2,25]],"date-time":"2026-02-25T00:00:00Z","timestamp":1771977600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Transplant Infectious Dis"],"published-print":{"date-parts":[[2026,5]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Despite decreased morbidity and mortality in patients with cystic fibrosis (CF) with CFTR modulators, a significant percentage still develop advanced lung disease. Nontuberculous mycobacteria (NTM) remain challenging pathogens with unclear effects on disease progression and post\u2010transplant outcome.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>NTM\u2010positive patients were identified from all CF patients treated at the University Hospitals of Zurich and Lausanne between 1998 and 2020. Disease course pre\u2010 and post\u2010transplant was recorded, and NTM\u2010positive patients were compared to patients without NTM infection for death or lung transplantation, as well as post\u2010transplant survival and development of chronic lung allograft dysfunction (CLAD).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Of 270 patients, 56 (20.7%) met criteria for NTM positivity (two independent cultures with the same organism), with Mycobacterium\n                      <jats:italic>abscessus<\/jats:italic>\n                      complex (MABSC) being the most common species (75.0%). Death or transplantation occurred in 12 of 56 (21.4%) NTM\u2010positive patients and 92 of 198 (46.5%) NTM\u2010negative patients (OR 3.17; 95% CI, 1.53\u20137.00;\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0=\u00a00.001). Post\u2010transplant mortality was higher in the NTM\u2010positive cohort (3 (27.3%) vs. 12 (13.0%); HR, 4.01, 95% CI, 1.08\u201314.86;\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0=\u00a00.024), while CLAD incidence did not differ significantly.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>\n                      NTM\u2010positive CF patients were associated with a lower pre\u2010transplant risk of death or transplantation. Post\u2010transplant mortality was higher in NTM\u2010positive patients, while no association between NTM infection and CLAD was observed. These findings indicate that favorable outcomes after lung transplantation are achievable in NTM\u2010positive patients. Thus, NTM\u2010infection should not be an absolute contraindication for lung transplantation, though careful individual assessment is essential due to the risk of serious complications.\n                      <jats:boxed-text content-type=\"graphic\" position=\"anchor\">\n                        <jats:graphic xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" mimetype=\"image\/png\" position=\"anchor\" specific-use=\"enlarged-web-image\" xlink:href=\"graphic\/tid70190-gra-0001-m.png\">\n                          <jats:alt-text>image<\/jats:alt-text>\n                        <\/jats:graphic>\n                      <\/jats:boxed-text>\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/tid.70190","type":"journal-article","created":{"date-parts":[[2026,3,8]],"date-time":"2026-03-08T10:09:47Z","timestamp":1772964587000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["The Role of Nontuberculous Mycobacteria in Patients With Cystic Fibrosis Advanced Lung Disease"],"prefix":"10.1111","volume":"28","author":[{"given":"Shirin","family":"Barcikowski","sequence":"first","affiliation":[{"name":"Department of Infectious Diseases and Hospital Epidemiology University Hospital Zurich University of Zurich  Zurich Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ribal Bou","family":"Mjahed","sequence":"additional","affiliation":[{"name":"Infectious Diseases Service and Transplantation Center Lausanne University Hospital University of Lausanne  Lausanne Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Oriol","family":"Manuel","sequence":"additional","affiliation":[{"name":"Infectious Diseases Service and Transplantation Center Lausanne University Hospital University of Lausanne  Lausanne Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mac\u00e9 M.","family":"Schuurmans","sequence":"additional","affiliation":[{"name":"Department of Pulmonology University Hospital Zurich University of Zurich  Zurich Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adrian","family":"Alonso","sequence":"additional","affiliation":[{"name":"Department of Pulmonology University Hospital Zurich University of Zurich  Zurich Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zisis","family":"Balmpouzis","sequence":"additional","affiliation":[{"name":"Lung Transplantation Center Division of Pulmonology Department of Medicine Lausanne University Hospital University of Lausanne  Lausanne Switzerland"},{"name":"Adult Cystic Fibrosis and CFTR\u2010related Disorders Center Division of Pulmonology Department of Medicine Lausanne University Hospital University of Lausanne  Lausanne Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jesica","family":"Mazza\u2010Stalder","sequence":"additional","affiliation":[{"name":"Lung Transplantation Center Division of Pulmonology Department of Medicine Lausanne University Hospital University of Lausanne  Lausanne Switzerland"},{"name":"Adult Cystic Fibrosis and CFTR\u2010related Disorders Center Division of Pulmonology Department of Medicine Lausanne University Hospital University of Lausanne  Lausanne Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Angela","family":"Koutsokera","sequence":"additional","affiliation":[{"name":"Lung Transplantation Center Division of Pulmonology Department of Medicine Lausanne University Hospital University of Lausanne  Lausanne Switzerland"},{"name":"Adult Cystic Fibrosis and CFTR\u2010related Disorders Center Division of Pulmonology Department of Medicine Lausanne University Hospital University of Lausanne  Lausanne 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