{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,12]],"date-time":"2026-09-12T10:10:10Z","timestamp":1789207810099,"version":"build-2803163510"},"reference-count":36,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2026,2,25]],"date-time":"2026-02-25T00:00:00Z","timestamp":1771977600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,2,25]],"date-time":"2026-02-25T00:00:00Z","timestamp":1771977600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Transplant Infectious Dis"],"published-print":{"date-parts":[[2026,5]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>\n                      Liver transplant recipients are at high risk of bacterial surgical site infection (SSI) following transplantation. However, they also have increased risks of antibiotic complications such as\n                      <jats:italic>C. difficile<\/jats:italic>\n                      and resistant organism infections. The optimal duration of perioperative antibiotic prophylaxis for liver transplantation is uncertain.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We analyzed infection outcomes in a total of 192 patients before and after a protocol change that shortened antibiotic prophylaxis duration at our institution. Durations were risk\u2010stratified with longer durations for patients hospitalized prior to liver transplantation. The recommended duration of antibiotic prophylaxis changed from 5\u00a0days or until transfer out of intensive care to 3\u00a0days for patients hospitalized prior to transplant and from 2\u00a0days to 1\u00a0day for all other patients.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      There was no increased rate of SSI or bacteremia following the decrease in duration, with a change from 2.4% to 2.8% in patients hospitalized prior to transplant and 7.5% to 2.9% in other patients. Risk of SSI or bacteremia was not significantly increased in a multivariable model (OR 0.50, 95% CI 0.07\u20132.24;\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0=\u00a00.41). There was no significant difference in readmission, graft rejection, graft failure, or mortality. Rates of acute kidney injury,\n                      <jats:italic>C. difficile<\/jats:italic>\n                      infection, and development of resistant organisms were not significantly different.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Shortening the duration of perioperative antibiotic prophylaxis in liver transplantation does not increase the risk of infection and may reduce harms of antibiotic exposure.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/tid.70192","type":"journal-article","created":{"date-parts":[[2026,3,8]],"date-time":"2026-03-08T10:30:52Z","timestamp":1772965852000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["No Increased Risk of Infection Following a Protocol Change to Decrease Duration of Perioperative Antibiotic Prophylaxis in Liver Transplantation"],"prefix":"10.1111","volume":"28","author":[{"ORCID":"https:\/\/orcid.org\/0009-0002-7802-3790","authenticated-orcid":false,"given":"Hutton","family":"Brandon","sequence":"first","affiliation":[{"name":"Division of Infectious Diseases Department of Internal Medicine University of Utah  Salt Lake City Utah USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2392-6036","authenticated-orcid":false,"given":"Crystal M.","family":"Truax","sequence":"additional","affiliation":[{"name":"Department of Pharmacy University of Utah Health  Salt Lake City Utah USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eduardo Rodriguez","family":"Zarate","sequence":"additional","affiliation":[{"name":"Transplant Hepatology Tampa General Medicine Group  Tampa Florida USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4636-3785","authenticated-orcid":false,"given":"Brandon J.","family":"Tritle","sequence":"additional","affiliation":[{"name":"Department of Pharmacy University of Utah Health  Salt Lake City Utah USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3429-4655","authenticated-orcid":false,"given":"Hannah","family":"Imlay","sequence":"additional","affiliation":[{"name":"Division of Infectious Diseases Department of Internal Medicine University of Utah  Salt Lake City Utah USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,2,25]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.4254\/wjh.v3.i4.83"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/lt.25486"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1177\/1526924820933824"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1097\/TP.0000000000004810"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/ctr.14631"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/ctr.13589"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/ajt.12798"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.idc.2023.04.001"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/ajt.16743"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1007\/s001470050082"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1097\/TP.0000000000001848"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1159\/000339789"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1002\/bimj.201700067"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.32614\/RJ-2021-053"},{"key":"e_1_2_8_16_1","unstructured":"\u201cR: A Language and Environment for Statistical Computing \u201dR Core Team last modified January 20 2026 https:\/\/cir.nii.ac.jp\/crid\/1370013168792282134."},{"key":"e_1_2_8_17_1","unstructured":"J. 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