{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,12]],"date-time":"2026-09-12T10:11:29Z","timestamp":1789207889937,"version":"build-2803163510"},"reference-count":16,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2026,3,10]],"date-time":"2026-03-10T00:00:00Z","timestamp":1773100800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2026,3,10]],"date-time":"2026-03-10T00:00:00Z","timestamp":1773100800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Transplant Infectious Dis"],"published-print":{"date-parts":[[2026,5]]},"abstract":"ABSTRACT<\/jats:title>\n \n Background<\/jats:title>\n (1\u20103)\u2010\u03b2\u2010D\u2010glucan (\u03b2\u2010D\u2010glucan), a component of fungal cell walls and an important diagnostic biomarker of invasive fungal infections, is affected by various factors, particularly in allogeneic hematopoietic cell transplantation (allo\u2010HCT) recipients. Patients receiving allo\u2010HCT also receive immunoglobulin replacement therapy (IgRT); however, little is known about the effects of different types of immunoglobulin products on serum \u03b2\u2010D\u2010glucans. Here, we examined the levels of serum \u03b2\u2010D\u2010glucan following IgRT, as well as the correlation between changes in serum \u03b2\u2010D\u2010glucan and IgG levels.<\/jats:p>\n <\/jats:sec>\n \n Methods<\/jats:title>\n Serum \u03b2\u2010D\u2010glucan levels in patients who underwent allo\u2010HCT and IgRT at our institution between 2021 and 2024 were analyzed retrospectively. Patients who had their serum \u03b2\u2010D\u2010glucan measured within 7\u00a0days before and after IgRT were included, and changes in serum \u03b2\u2010D\u2010glucan levels were evaluated across product types. Finally, the magnitude of these changes was assessed using effect sizes.<\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n \n A total of 125 administrations of three types of immunoglobulin product (Privegen [\n n\u00a0=\u00a0<\/jats:italic>\n 63], Venoglobulin [\n n<\/jats:italic>\n \u00a0=\u00a038], and Venilon\u2010I [\n n<\/jats:italic>\n \u00a0=\u00a024]) were examined. The median dose of immunoglobulin was 538.9 (57.4\u2013700.9) mg\/kg. We noted a significant increase in serum \u03b2\u2010D\u2010glucan levels after administration of Privigen, with a large effect size (Cohen's\n dz<\/jats:italic>\n \u00a0=\u00a00.92; 95% confidence interval 0.48\u20131.35,\n p<\/jats:italic>\n \u00a0<\u00a00.01). No meaningful changes were detected with Venoglobulin or Venilon\u2010I. Elevated serum \u03b2\u2010D\u2010glucan levels returned to baseline within approximately 3\u00a0weeks of Privigen administration. Multivariable analysis indicated that Privigen was an independent factor associated with higher serum \u03b2\u2010D\u2010glucan levels.\n <\/jats:p>\n <\/jats:sec>\n \n Conclusion<\/jats:title>\n \n Different immunoglobulin products have different effects on serum \u03b2\u2010D\u2010glucan levels after IgRT.\n \n \n image<\/jats:alt-text>\n <\/jats:graphic>\n <\/jats:boxed-text>\n <\/jats:p>\n <\/jats:sec>","DOI":"10.1111\/tid.70194","type":"journal-article","created":{"date-parts":[[2026,3,10]],"date-time":"2026-03-10T11:15:23Z","timestamp":1773141323000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Effects of Various Immunoglobulin Products on Serum (1\u20103)\u2010\u03b2\u2010D\u2010glucan Levels"],"prefix":"10.1111","volume":"28","author":[{"given":"Hidekatsu","family":"Yae","sequence":"first","affiliation":[{"name":"Department of Hematology Osaka Metropolitan University Graduate School of Medicine Osaka Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0388-3836","authenticated-orcid":false,"given":"Mitsutaka","family":"Nishimoto","sequence":"additional","affiliation":[{"name":"Department of Hematology Osaka Metropolitan University Graduate School of Medicine Osaka Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1133-8459","authenticated-orcid":false,"given":"Hiroshi","family":"Okamura","sequence":"additional","affiliation":[{"name":"Department of Hematology Osaka Metropolitan University Graduate School of Medicine Osaka Japan"},{"name":"Department of Laboratory Medicine and Medical Informatics Osaka Metropolitan University Osaka Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4548-147X","authenticated-orcid":false,"given":"Masatomo","family":"Kuno","sequence":"additional","affiliation":[{"name":"Department of Hematology Osaka Metropolitan University Graduate School of Medicine Osaka Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5230-6904","authenticated-orcid":false,"given":"Yosuke","family":"Makuuchi","sequence":"additional","affiliation":[{"name":"Department of Hematology Osaka Metropolitan University Graduate School of Medicine Osaka Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0008-6298-8989","authenticated-orcid":false,"given":"Hideo","family":"Miyagawa","sequence":"additional","affiliation":[{"name":"Preventive Medicine and Environmental Health Osaka Metropolitan University Graduate School of Medicine Osaka Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yasuhiro","family":"Nakashima","sequence":"additional","affiliation":[{"name":"Department of Hematology Osaka Metropolitan University Graduate School of Medicine Osaka Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mika","family":"Nakamae","sequence":"additional","affiliation":[{"name":"Department of Hematology Osaka Metropolitan University Graduate School of Medicine Osaka Japan"},{"name":"Department of Laboratory Medicine and Medical Informatics Osaka Metropolitan University Osaka Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masayuki","family":"Hino","sequence":"additional","affiliation":[{"name":"Department of Hematology Osaka Metropolitan University Graduate School of Medicine Osaka Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hirohisa","family":"Nakamae","sequence":"additional","affiliation":[{"name":"Department of Hematology Osaka Metropolitan University Graduate School of Medicine Osaka Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,3,10]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1086\/432470"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.3390\/jof7121046"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/ciab1028"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1128\/JCM.02972\u201015"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jinf.2017.10.017"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmi.2020.02.036"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbmt.2009.07.004"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood\u20102014\u201001\u2010552984"},{"issue":"6","key":"e_1_2_8_10_1","first-page":"825","article-title":"1994 Consensus Conference on Acute GVHD Grading","volume":"15","author":"Przepiorka 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