{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T01:21:14Z","timestamp":1787016074205,"version":"build-2736575974"},"reference-count":42,"publisher":"Wiley","license":[{"start":{"date-parts":[[2026,3,10]],"date-time":"2026-03-10T00:00:00Z","timestamp":1773100800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2026,3,10]],"date-time":"2026-03-10T00:00:00Z","timestamp":1773100800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Transplant Infectious Dis"],"abstract":"ABSTRACT<\/jats:title>\n \n Background<\/jats:title>\n Dengue virus (DENV) infection is an increasing public health concern in immunocompromised patients, including those with hematological disease (HD). Clinical overlap between DENV and HD\u2010related complications often leads to underdiagnosis, and data on DENV outcomes in HD patients were limited during the 2023\u20132024 outbreak in Argentina.<\/jats:p>\n <\/jats:sec>\n \n Methods<\/jats:title>\n We conducted a retrospective, multicenter analysis of HD patients with laboratory\u2010confirmed or highly probable DENV infection reported to the Argentine DANGO registry between November 2023 and May 2024. Seven centers participated. Patients aged \u226516 years were included, and demographic, clinical, laboratory, treatment, and outcome data were analyzed descriptively.<\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n Thirty\u2010three HD patients with DENV were included. Median age was 54 years (IQR 33\u201363), and 70% were male. Non\u2010Hodgkin lymphoma (30%) and acute myeloid leukemia (21%) were the most common HD. Most patients (82%) were receiving active chemotherapy, and 24% had undergone hematopoietic stem cell transplantation (HSCT). Hospitalization was required in 64% of cases. Thrombocytopenia occurred in 90%, leukopenia in 67%, and hematocrit <30% in 52%. DENV with warning signs was observed in 64% of patients. Two cases of transfusion\u2010associated DENV were documented via PCR\u2010positive platelet donor samples. Overall mortality was 6% (2\/33), with both deaths directly attributable to DENV\u2010related complications.<\/jats:p>\n <\/jats:sec>\n \n Conclusions<\/jats:title>\n \n DENV infection in patients with HD is associated with frequent complications, high hospitalization rates, and substantial morbidity and non\u2010negligible mortality. Symptom overlap with HD\u2010related conditions complicates diagnosis. Increased clinical awareness, standardized diagnostic approaches, and strengthened transfusion safety measures are essential in endemic areas, especially during outbreaks.\n \n \n image<\/jats:alt-text>\n <\/jats:graphic>\n <\/jats:boxed-text>\n <\/jats:p>\n <\/jats:sec>","DOI":"10.1111\/tid.70201","type":"journal-article","created":{"date-parts":[[2026,3,10]],"date-time":"2026-03-10T11:27:02Z","timestamp":1773142022000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Challenges of Dengue in Hematological Disease Patients: Descriptive Analysis From the DANGO Registry During the 2023\u20132024 Outbreak in Argentina"],"prefix":"10.1111","author":[{"given":"Gustavo Adolfo","family":"M\u00e9ndez","sequence":"first","affiliation":[{"name":"Hospital Escuela de Agudos Dr Ram\u00f3n Madariaga Posadas Misiones Argentina"},{"name":"Facultad De Medicina Universidad Cat\u00f3lica de Las Misiones Misiones Argentina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carla","family":"Niveyro","sequence":"additional","affiliation":[{"name":"Hospital Escuela de Agudos Dr Ram\u00f3n Madariaga Posadas Misiones Argentina"},{"name":"Facultad De Medicina Universidad Cat\u00f3lica de Las Misiones Misiones Argentina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pedro Andr\u00e9s","family":"Villalba Apestegui","sequence":"additional","affiliation":[{"name":"Hospital Escuela de Agudos Dr Ram\u00f3n Madariaga Posadas Misiones Argentina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Victoria Isabel","family":"Martin","sequence":"additional","affiliation":[{"name":"Hospital Escuela de Agudos Dr Ram\u00f3n Madariaga Posadas Misiones Argentina"},{"name":"Facultad De Medicina Universidad Cat\u00f3lica de Las Misiones Misiones Argentina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lucila Mar\u00eda","family":"Compa\u00f1y Kec","sequence":"additional","affiliation":[{"name":"Hospital Escuela de Agudos Dr Ram\u00f3n Madariaga Posadas Misiones Argentina"},{"name":"Facultad De Medicina Universidad Cat\u00f3lica de Las Misiones Misiones Argentina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mar\u00eda Cynthia","family":"Tomasino","sequence":"additional","affiliation":[{"name":"Hospital Escuela de Agudos Dr Ram\u00f3n Madariaga Posadas Misiones Argentina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mariana del Carmen","family":"del Marull","sequence":"additional","affiliation":[{"name":"Hospital Escuela de Agudos Dr Ram\u00f3n Madariaga Posadas Misiones Argentina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haydee Ingrid","family":"Bernard","sequence":"additional","affiliation":[{"name":"Hospital Escuela de Agudos Dr Ram\u00f3n Madariaga Posadas Misiones Argentina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Claudia Patricia Lorena","family":"Fern\u00e1ndez","sequence":"additional","affiliation":[{"name":"Hospital Escuela de Agudos Dr Ram\u00f3n Madariaga Posadas Misiones Argentina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Flavia Marcela","family":"Pelech","sequence":"additional","affiliation":[{"name":"Hospital Escuela de Agudos Dr Ram\u00f3n Madariaga Posadas Misiones Argentina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria Fernanda","family":"Tosin","sequence":"additional","affiliation":[{"name":"Hospital S.A.M.I.C. El Cruce Florencio Varela Buenos Aires Argentina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mar\u00eda Fernanda","family":"Gonz\u00e1lez\u2010Hobecker","sequence":"additional","affiliation":[{"name":"Hospital S.A.M.I.C. Eldorado Misiones Argentina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karen Beatrice","family":"Duranona","sequence":"additional","affiliation":[{"name":"Hospital S.A.M.I.C. Eldorado Misiones Argentina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Angela Daiana","family":"Jara","sequence":"additional","affiliation":[{"name":"Hospital Dra. Marta T. Schwarz Puerto Iguaz\u00fa Misiones Argentina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Justus","family":"Cornely","sequence":"additional","affiliation":[{"name":"Institute of Translational Research Cologne Excellence Cluster on Cellular Stress Responses in Aging\u2010Associated Diseases (CECAD) Faculty of Medicine and University Hospital Cologne University of Cologne Cologne Germany"},{"name":"Department of Internal Medicine Center for Integrated Oncology Aachen Bonn Cologne Duesseldorf (CIO ABCD) and Excellence Center for Medical Mycology (ECMM) University of Cologne Faculty of Medicine, and University Hospital Cologne Cologne Germany"},{"name":"German Centre for Infection Research (DZIF) Partner Site Bonn\u2010Cologne Cologne Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9599-3137","authenticated-orcid":false,"given":"Oliver A.","family":"Cornely","sequence":"additional","affiliation":[{"name":"Institute of Translational Research Cologne Excellence Cluster on Cellular Stress Responses in Aging\u2010Associated Diseases (CECAD) Faculty of Medicine and University Hospital Cologne University of Cologne Cologne Germany"},{"name":"Department of Internal Medicine Center for Integrated Oncology Aachen Bonn Cologne Duesseldorf (CIO ABCD) and Excellence Center for Medical Mycology (ECMM) University of Cologne Faculty of Medicine, and University Hospital Cologne Cologne Germany"},{"name":"German Centre for Infection Research (DZIF) Partner Site Bonn\u2010Cologne Cologne Germany"},{"name":"Clinical Trials Centre Cologne (ZKS K\u00f6ln) University Hospital Cologne Faculty of Medicine University of Cologne Cologne Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jon","family":"Salmanton\u2010Garc\u00eda","sequence":"additional","affiliation":[{"name":"Institute of Translational Research Cologne Excellence Cluster on Cellular Stress Responses in Aging\u2010Associated Diseases (CECAD) Faculty of Medicine and University Hospital Cologne University of Cologne Cologne Germany"},{"name":"Department of Internal Medicine Center for Integrated Oncology Aachen Bonn Cologne Duesseldorf (CIO ABCD) and Excellence Center for Medical Mycology (ECMM) University of Cologne Faculty of Medicine, and University Hospital Cologne Cologne Germany"},{"name":"German Centre for Infection Research (DZIF) Partner Site Bonn\u2010Cologne Cologne Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,3,10]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.hemonc.2013.05.005"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140\u20106736(23)02576\u2010X"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1093\/infdis\/jiv326"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.idcr.2021.e01220"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1177\/2050313X241269637"},{"key":"e_1_2_11_7_1","volume-title":"Bolet\u00edn Epidemiol\u00f3gico Nacional de la Argentina","author":"Direcci\u00f3n de Epidemiolog\u00eda","year":"2024"},{"key":"e_1_2_11_8_1","unstructured":"\u201cDengue. 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