{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,12]],"date-time":"2026-09-12T10:10:20Z","timestamp":1789207820744,"version":"build-2803163510"},"reference-count":42,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2026,4,18]],"date-time":"2026-04-18T00:00:00Z","timestamp":1776470400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,4,18]],"date-time":"2026-04-18T00:00:00Z","timestamp":1776470400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Transplant Infectious Dis"],"published-print":{"date-parts":[[2026,5]]},"abstract":"ABSTRACT<\/jats:title>\n \n Background<\/jats:title>\n Invasive fusariosis (IF) is a rare but often fatal mold infection in immunocompromised patients, particularly after allogeneic hematopoietic stem cell transplantation (HSCT). Despite antifungal prophylaxis and treatment, mortality remains high.<\/jats:p>\n <\/jats:sec>\n \n Methods<\/jats:title>\n We retrospectively reviewed all allogeneic HSCT recipients for hematological malignancies at our center (2010\u20132024) and identified proven IF cases. Species identification was based on multigene sequencing, and antifungal susceptibility testing was performed.<\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n \n Among 2359 allogeneic HSCTs, 17 proven IF cases (7.2\/1000) were identified. Patients more often had prior HSCT (58.8% vs. 19.8%,\n p<\/jats:italic>\n \u00a0=\u00a00.002) and were transplanted in non\u2010complete remission (94.1% vs. 75.8%). Median onset was 19 days (range, 2\u20131011) posttransplant, with a median neutrophil count of 1\/\u00b5L (range, 1\u20137097) at diagnosis; 64.7% were pre\u2010engraftment. Prophylaxis included micafungin (\n n<\/jats:italic>\n \u00a0=\u00a010), posaconazole (\n n<\/jats:italic>\n \u00a0=\u00a04), and voriconazole (\n n<\/jats:italic>\n \u00a0=\u00a03). Species:\n Fusarium solani<\/jats:italic>\n complex (\n n<\/jats:italic>\n \u00a0=\u00a011),\n Fusarium dimerum<\/jats:italic>\n complex (\n n<\/jats:italic>\n \u00a0=\u00a04), and\n Fusarium fujikuroi<\/jats:italic>\n complex (\n n<\/jats:italic>\n \u00a0=\u00a02). All isolates had high micafungin MECs (>\u00a016 \u00b5g\/mL); the median amphotericin B MIC was 4\u00a0\u00b5g\/mL, voriconazole MIC >\u00a08 \u00b5g\/mL. Median overall survival was 8 days; mortality reached 82.4% by Day 84. In univariate analysis, combination liposomal amphotericin B (L\u2010AMB) plus voriconazole (\n p<\/jats:italic>\n \u00a0=\u00a00.013) and neutrophil recovery (\n p<\/jats:italic>\n \u00a0=\u00a00.008) were associated with improved survival. No clear trends were noted in antifungal susceptibility between survivors and non\u2010survivors.\n <\/jats:p>\n <\/jats:sec>\n \n Conclusions<\/jats:title>\n \n IF after allogeneic HSCT is rare but highly lethal. Despite the small sample size, outcomes were not clearly associated with MIC values. Early L\u2010AMB plus VRCZ and neutrophil recovery may be associated with improved survival.\n \n \n image<\/jats:alt-text>\n <\/jats:graphic>\n <\/jats:boxed-text>\n <\/jats:p>\n <\/jats:sec>","DOI":"10.1111\/tid.70216","type":"journal-article","created":{"date-parts":[[2026,4,18]],"date-time":"2026-04-18T08:34:11Z","timestamp":1776501251000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Clinical and Microbiological Insights Into Invasive Fusariosis Following Allogeneic Hematopoietic Stem Cell Transplantation: A 15\u2010Year Single\u2010Center Analysis"],"prefix":"10.1111","volume":"28","author":[{"ORCID":"https:\/\/orcid.org\/0009-0008-1472-4727","authenticated-orcid":false,"given":"Jotaro","family":"Yamamoto","sequence":"first","affiliation":[{"name":"Department of Hematology Toranomon Hospital Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sho","family":"Ogura","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases Toranomon Hospital Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shinsuke","family":"Takagi","sequence":"additional","affiliation":[{"name":"Department of Hematology Toranomon Hospital Tokyo Japan"},{"name":"Center for Long\u2010Term Follow\u2010Up After Hematopoietic Cell Transplantation Toranomon Hospital Tokyo Japan"},{"name":"Okinaka Memorial Institute for Medical Research Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takayuki","family":"Shinohara","sequence":"additional","affiliation":[{"name":"Department of Fungal Infection National Institute of Infectious Diseases Japan Institute of Health Security Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hirofumi","family":"Takano","sequence":"additional","affiliation":[{"name":"Department of Hematology Toranomon Hospital Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mika","family":"Kuno","sequence":"additional","affiliation":[{"name":"Department of Hematology Toranomon Hospital Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mizuki","family":"Haraguchi","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases Toranomon Hospital Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Otoya","family":"Watanabe","sequence":"additional","affiliation":[{"name":"Department of Hematology Toranomon Hospital Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takashi","family":"Sakoh","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases Toranomon Hospital Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kyosuke","family":"Yamaguchi","sequence":"additional","affiliation":[{"name":"Department of Hematology Toranomon Hospital Kajigaya Kanagawa Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masayo","family":"Morishima","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases Toranomon Hospital Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kosei","family":"Kageyama","sequence":"additional","affiliation":[{"name":"Department of Hematology Toranomon Hospital Kajigaya Kanagawa Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9256-609X","authenticated-orcid":false,"given":"Daisuke","family":"Kaji","sequence":"additional","affiliation":[{"name":"Department of Hematology Toranomon Hospital Tokyo Japan"},{"name":"Department of Transfusion Medicine and Cellular Therapy Toranomon Hospital Tokyo Japan"},{"name":"Center for Cellular Therapy Toranomon Hospital Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuki","family":"Taya","sequence":"additional","affiliation":[{"name":"Department of Hematology Toranomon Hospital Tokyo Japan"},{"name":"Department of Transfusion Medicine and Cellular Therapy Toranomon Hospital Tokyo Japan"},{"name":"Center for Cellular Therapy Toranomon Hospital Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aya","family":"Nishida","sequence":"additional","affiliation":[{"name":"Department of Hematology Toranomon Hospital Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Muneyoshi","family":"Kimura","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases Toranomon Hospital Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hisashi","family":"Yamamoto","sequence":"additional","affiliation":[{"name":"Department of Hematology Toranomon Hospital Tokyo Japan"},{"name":"Center for Long\u2010Term Follow\u2010Up After Hematopoietic Cell Transplantation Toranomon Hospital Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ami","family":"Koizumi","sequence":"additional","affiliation":[{"name":"Department of Fungal Infection National Institute of Infectious Diseases Japan Institute of Health Security Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6355-716X","authenticated-orcid":false,"given":"Masahiro","family":"Abe","sequence":"additional","affiliation":[{"name":"Department of Fungal Infection National Institute of Infectious Diseases Japan Institute of Health Security Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yasutaka","family":"Hoshino","sequence":"additional","affiliation":[{"name":"Department of Fungal Infection National Institute of Infectious Diseases Japan Institute of Health Security Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sayoko","family":"Oiki","sequence":"additional","affiliation":[{"name":"Department of Fungal Infection National Institute of Infectious Diseases Japan Institute of Health Security Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takanori","family":"Horiguchi","sequence":"additional","affiliation":[{"name":"Department of Fungal Infection National Institute of Infectious Diseases Japan Institute of Health Security Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takashi","family":"Umeyama","sequence":"additional","affiliation":[{"name":"Department of Fungal Infection National Institute of Infectious Diseases Japan Institute of Health Security Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuki","family":"Asano\u2010Mori","sequence":"additional","affiliation":[{"name":"Center for Long\u2010Term Follow\u2010Up After Hematopoietic Cell Transplantation Toranomon Hospital Tokyo Japan"},{"name":"Department of Transfusion Medicine and Cellular Therapy Toranomon Hospital Tokyo Japan"},{"name":"Center for Cellular Therapy Toranomon Hospital Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Go","family":"Yamamoto","sequence":"additional","affiliation":[{"name":"Department of Hematology Toranomon Hospital Tokyo Japan"},{"name":"Center for Cellular Therapy Toranomon Hospital Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Atsushi","family":"Wake","sequence":"additional","affiliation":[{"name":"Department of Hematology Toranomon Hospital Kajigaya Kanagawa Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hideki","family":"Araoka","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases Toranomon Hospital Tokyo Japan"},{"name":"Okinaka Memorial Institute for Medical Research Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yoshitsugu","family":"Miyazaki","sequence":"additional","affiliation":[{"name":"Department of Fungal Infection National Institute of Infectious Diseases Japan Institute of Health Security Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shuichi","family":"Taniguchi","sequence":"additional","affiliation":[{"name":"Department of Hematology Toranomon Hospital Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Naoyuki","family":"Uchida","sequence":"additional","affiliation":[{"name":"Department of Hematology Toranomon Hospital Tokyo Japan"},{"name":"Okinaka Memorial Institute for Medical Research Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,4,18]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1128\/cmr.00159\u201022"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.3390\/jof7100815"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1128\/CMR.00014\u201007"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.11510"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1086\/383319"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/1469\u20100691.12409"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1086\/651263"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1086\/522189"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/1469\u20100691.12002"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.4103\/hemoncstem.HEMONCSTEM\u2010D\u201024\u201000009"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1093\/jac\/dkn022"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jgar.2020.12.016"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1093\/jac\/dkaa516"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.simyco.2021.100116"},{"key":"e_1_2_10_16_1","volume-title":"Reference Method for Broth Dilution Antifungal Susceptibility Testing of Filamentous Fungi; Approved Standard\u2014Second Edition (CLSI document M38\u2010A2)","author":"Clinical and Laboratory Standards Institute","year":"2008"},{"key":"e_1_2_10_17_1","volume-title":"Reference Method for Broth Dilution Antifungal Susceptibility Testing of Filamentous Fungi","author":"Clinical and Laboratory Standards Institute","year":"2017"},{"key":"e_1_2_10_18_1","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/ciz1008"},{"key":"e_1_2_10_19_1","doi-asserted-by":"publisher","DOI":"10.1086\/590566"},{"key":"e_1_2_10_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbmt.2009.07.004"},{"key":"e_1_2_10_21_1","doi-asserted-by":"publisher","DOI":"10.1097\/00007890\u2010197410000\u201000001"},{"key":"e_1_2_10_22_1","doi-asserted-by":"publisher","DOI":"10.1038\/bmt.2012.244"},{"key":"e_1_2_10_23_1","doi-asserted-by":"publisher","DOI":"10.1038\/bmt.2015.263"},{"key":"e_1_2_10_24_1","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/ciu947"},{"key":"e_1_2_10_25_1","doi-asserted-by":"publisher","DOI":"10.1038\/emi.2016.126"},{"key":"e_1_2_10_26_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0133644"},{"key":"e_1_2_10_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmi.2018.05.006"},{"key":"e_1_2_10_28_1","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.00636\u201016"},{"key":"e_1_2_10_29_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10096\u2010013\u20101826\u20108"},{"key":"e_1_2_10_30_1","doi-asserted-by":"publisher","DOI":"10.1093\/jac\/dkt256"},{"key":"e_1_2_10_31_1","doi-asserted-by":"publisher","DOI":"10.1099\/jmm.0.038166\u20100"},{"key":"e_1_2_10_32_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.idcr.2015.10.004"},{"key":"e_1_2_10_33_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11046\u2010019\u20100318\u20105"},{"key":"e_1_2_10_34_1","doi-asserted-by":"publisher","DOI":"10.1128\/JCM.05946\u201011"},{"key":"e_1_2_10_35_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0087784"},{"key":"e_1_2_10_36_1","doi-asserted-by":"publisher","DOI":"10.1093\/jac\/dkad377"},{"key":"e_1_2_10_37_1","doi-asserted-by":"publisher","DOI":"10.1093\/mmy\/myz060"},{"key":"e_1_2_10_38_1","doi-asserted-by":"publisher","DOI":"10.1111\/myc.12918"},{"key":"e_1_2_10_39_1","doi-asserted-by":"publisher","DOI":"10.1093\/mmy\/myad061"},{"key":"e_1_2_10_40_1","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.00020\u201009"},{"key":"e_1_2_10_41_1","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.02456\u201015"},{"key":"e_1_2_10_42_1","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.01495\u201021"},{"key":"e_1_2_10_43_1","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.00286\u201010"}],"container-title":["Transplant Infectious Disease"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/tid.70216","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/tid.70216","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/tid.70216","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,9,12]],"date-time":"2026-09-12T09:56:42Z","timestamp":1789207002000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/tid.70216"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,4,18]]},"references-count":42,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2026,5]]}},"alternative-id":["10.1111\/tid.70216"],"URL":"https:\/\/doi.org\/10.1111\/tid.70216","archive":["Portico"],"relation":{},"ISSN":["1398-2273","1399-3062"],"issn-type":[{"value":"1398-2273","type":"print"},{"value":"1399-3062","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,4,18]]},"assertion":[{"value":"2026-02-06","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-04-01","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-04-18","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e70216"}}