{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,12]],"date-time":"2026-09-12T10:10:20Z","timestamp":1789207820726,"version":"build-2803163510"},"reference-count":27,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2026,4,16]],"date-time":"2026-04-16T00:00:00Z","timestamp":1776297600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,4,16]],"date-time":"2026-04-16T00:00:00Z","timestamp":1776297600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Transplant Infectious Dis"],"published-print":{"date-parts":[[2026,5]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Pulmonary complications after allogeneic hematopoietic cell transplantation (allo\u2010HCT) are a significant cause of morbidity and mortality. Lung biopsy may help categorize, but its diagnostic yield in this population remains poorly defined.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We aimed to determine the accuracy (descriptive histopathological report), diagnostic yield (specific histopathologic diagnosis that plausibly explained radiologic abnormalities), complication rates, and clinical utility of lung biopsies performed in patients referred for allo\u2010HCT at a comprehensive cancer center for pulmonary opacities. We conducted a retrospective cohort study of 76 lung biopsies (image\u2010guided transthoracic, wedge resection, or transbronchial) performed on 70 patients referred for allo\u2010HCT.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Lung biopsy was accurate in 93% (\n                      <jats:italic>n<\/jats:italic>\n                      \u00a0=\u00a071\/76) of procedures. The diagnostic yield was 72% (\n                      <jats:italic>n<\/jats:italic>\n                      \u00a0=\u00a055\/76): malignancy (26%), organizing pneumonia (24%), and infection (16%). Lung biopsy led to a change in management in 51% of procedures (\n                      <jats:italic>n<\/jats:italic>\n                      \u00a0=\u00a039\/76); effective (beneficial) in 79% of cases. Major complications occurred in 7% (\n                      <jats:italic>n<\/jats:italic>\n                      \u00a0=\u00a05\/76) of procedures: four had a pneumothorax requiring chest tube drainage, and one had an intraprocedural cardiac arrest resulting in death.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>\n                      In this highly selected cohort of patients referred for allo\u2010HCT, lung biopsy provided a high diagnostic yield and often altered subsequent management. Integration of biopsy into diagnostic pathways may improve care in selected patients.\n                      <jats:boxed-text content-type=\"graphic\" position=\"anchor\">\n                        <jats:graphic xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" mimetype=\"image\/png\" position=\"anchor\" specific-use=\"enlarged-web-image\" xlink:href=\"graphic\/tid70217-gra-0001-m.png\">\n                          <jats:alt-text>image<\/jats:alt-text>\n                        <\/jats:graphic>\n                      <\/jats:boxed-text>\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/tid.70217","type":"journal-article","created":{"date-parts":[[2026,4,17]],"date-time":"2026-04-17T05:19:38Z","timestamp":1776403178000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Lung Biopsies in Patients Referred for Allogeneic Hematopoietic Cell Transplantation: Diagnostic Accuracy, Diagnostic Yield, and Clinical Utility"],"prefix":"10.1111","volume":"28","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8355-433X","authenticated-orcid":false,"given":"Sergio","family":"Rodriguez\u2010Rodriguez","sequence":"first","affiliation":[{"name":"Messner Bone Marrow Transplant Program Princess Margaret Cancer Centre University Health Network  Toronto Ontario Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3105-1631","authenticated-orcid":false,"given":"Ayman","family":"Sayyed","sequence":"additional","affiliation":[{"name":"Windsor Regional Hospital Schulich School of Medicine &amp; Dentistry Western University  Windsor Ontario Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Swe Mar","family":"Linn","sequence":"additional","affiliation":[{"name":"Messner Bone Marrow Transplant Program Princess Margaret Cancer Centre University Health Network  Toronto Ontario Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Caden","family":"Chiarello","sequence":"additional","affiliation":[{"name":"Messner Bone Marrow Transplant Program Princess Margaret Cancer Centre University Health Network  Toronto Ontario Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0520-4312","authenticated-orcid":false,"given":"Mats","family":"Remberger","sequence":"additional","affiliation":[{"name":"Department of Medical Sciences (IMV) Clinical Research and Development Unit (KFUE) Uppsala University Hospital Uppsala University  Uppsala Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Igor","family":"Novitzky\u2010Basso","sequence":"additional","affiliation":[{"name":"Messner Bone Marrow Transplant Program Princess Margaret Cancer Centre University Health Network  Toronto Ontario Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7281-4850","authenticated-orcid":false,"given":"Patrik","family":"Rogalla","sequence":"additional","affiliation":[{"name":"Radiology Department Princess Margaret Cancer Centre University Health Network  Toronto Ontario Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shahid","family":"Husain","sequence":"additional","affiliation":[{"name":"Transplant Infectious Diseases Clinic Toronto General Hospital University Health Network  Toronto Ontario Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2163-6644","authenticated-orcid":false,"given":"Jonas","family":"Mattsson","sequence":"additional","affiliation":[{"name":"Messner Bone Marrow Transplant Program Princess Margaret Cancer Centre University Health Network  Toronto Ontario Canada"},{"name":"Gloria and Seymour Epstein Chair in Cell Therapy and Transplantation Department of Medical Oncology and Hematology Princess Margaret Cancer Centre University Health Network (UHN) University of Toronto  Toronto Ontario Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,4,16]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbmt.2018.04.012"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.4274\/balkanmedj.2017.1635"},{"key":"e_1_2_11_4_1","first-page":"1385","article-title":"Pulmonary Complications in Adult Blood and Marrow Transplant Recipients","volume":"128","author":"Sharma S.","year":"2005","journal-title":"Autopsy Findings"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.3390\/jcm10153227"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.rmed.2025.108208"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood.2023023249"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.1183\/16000617.0119\u20102019"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.200502\u2010212OC"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jtct.2023.01.029"},{"key":"e_1_2_11_11_1","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/ciw326"},{"key":"e_1_2_11_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/1469\u20100691.12014"},{"key":"e_1_2_11_13_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2014.58.0480"},{"key":"e_1_2_11_14_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.bmt.1705505"},{"key":"e_1_2_11_15_1","doi-asserted-by":"publisher","DOI":"10.1038\/bmt.2017.238"},{"key":"e_1_2_11_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.resinv.2022.08.008"},{"key":"e_1_2_11_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbmt.2016.08.023"},{"key":"e_1_2_11_18_1","doi-asserted-by":"publisher","DOI":"10.1513\/AnnalsATS.202302\u2010182OC"},{"key":"e_1_2_11_19_1","first-page":"634","article-title":"Assessment of Advanced Diagnostic Bronchoscopy Outcomes for Peripheral Lung Lesions: A Delphi Consensus Definition of Diagnostic Yield and Recommendations for Patient\u2010Centered Study Designs","volume":"209","author":"Gonzalez A. 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