{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T03:51:36Z","timestamp":1791258696405,"version":"4.1.0"},"reference-count":21,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2026,6,18]],"date-time":"2026-06-18T00:00:00Z","timestamp":1781740800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,6,18]],"date-time":"2026-06-18T00:00:00Z","timestamp":1781740800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Transplant Infectious Dis"],"published-print":{"date-parts":[[2026,9]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Cytomegalovirus (CMV) is among the most common infectious complications following allogeneic hematopoietic cell transplantation (allo\u2010HCT). The CMV T\u2010cell immunity panel (CMV\u2010TCIP, Viracor) assesses CMV cell\u2010mediated immunity (CMV\u2010CMI); however, its utility among pediatric allo\u2010HCT recipients remains unknown.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      A retrospective analysis (January 2020\u2013January 2024) among pediatric (\u2264\u00a018 years) allo\u2010HCT recipients with CMV DNAemia and at least one CMV\u2010TCIP test was performed. A %CMV\u2010CD4\n                      <jats:sup>+<\/jats:sup>\n                      or %CMV\u2010CD8\n                      <jats:sup>+<\/jats:sup>\n                      IFN\u2010\u03b3 \u2264\u00a00.2% was categorized as a poor response, whereas a result &gt;\u00a00.2% was classified as adequate. Clinically significant CMV infection (csCMVi) was defined as viral load (VL) \u2265\u00a0500\u00a0IU\/mL. CMV\u2010TCIP results were compared to CMV VL and the development of csCMVi after allo\u2010HCT.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Twenty\u2010seven CMV\u2010TCIP results from 10 allo\u2010HCT recipients were analyzed. The median age at transplant was 8.5 years (IQR 2.75\u201314.3), predominantly for hematologic malignancy (70%), and with high\u2010risk CMV serostatus (R+, 90%). At the time of CMV\u2010TCIP testing, subjects with a VL &lt;\u00a0500\u00a0IU\/mL had a higher %CMV\u2010CD4\n                      <jats:sup>+<\/jats:sup>\n                      IFN\u2010\u03b3 compared to those with a VL \u2265\u00a0500 IU\/mL (0.36 vs. 0.04,\n                      <jats:italic>p\u00a0<\/jats:italic>\n                      =\u00a00.02). Peak CMV VLs were lower in those with adequate CD4\n                      <jats:sup>+<\/jats:sup>\n                      and CD8\n                      <jats:sup>+<\/jats:sup>\n                      T\u2010cell responses than in those with poor CD4\n                      <jats:sup>+<\/jats:sup>\n                      and CD8\n                      <jats:sup>+<\/jats:sup>\n                      T\u2010cell responses. In those who received CMV viral\u2010specific T\u2010cells (CMV\u2010VST,\n                      <jats:italic>n<\/jats:italic>\n                      \u00a0=\u00a05), increased %CD4\n                      <jats:sup>+<\/jats:sup>\n                      and %CD8\n                      <jats:sup>+<\/jats:sup>\n                      IFN\u2010\u03b3 responses post\u2010infusion were observed with a concordant downward trend in VL.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>\n                      Our results demonstrate that the development of CMV\u2010CMI (particularly CD4\n                      <jats:sup>+<\/jats:sup>\n                      IFN\u2010\u03b3 &gt;\u00a00.2%) was observed with lower CMV VLs and may provide immunologic insights into pediatric allo\u2010HCT recipients receiving CMV\u2010VST.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/tid.70253","type":"journal-article","created":{"date-parts":[[2026,6,19]],"date-time":"2026-06-19T03:41:37Z","timestamp":1781840497000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Evaluation of Cytomegalovirus (CMV) T\u2010Cell Mediated Immunity in Children With CMV DNAemia After Allogeneic Hematopoietic Cell Transplantation"],"prefix":"10.1111","volume":"28","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4633-8552","authenticated-orcid":false,"given":"Varvara","family":"Probst","sequence":"first","affiliation":[{"name":"Division of Infectious Diseases Department of Pediatrics University of Florida  Gainesville Florida USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7037-4022","authenticated-orcid":false,"given":"Christopher P.","family":"Ouellette","sequence":"additional","affiliation":[{"name":"Host Defense Program Division of Infectious Diseases Department of Pediatrics Nationwide Children's Hospital The Ohio State University College of Medicine  Columbus Ohio USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7907-957X","authenticated-orcid":false,"given":"Eunkyung","family":"Song","sequence":"additional","affiliation":[{"name":"Host Defense Program Division of Infectious Diseases Department of Pediatrics Nationwide Children's Hospital The Ohio State University College of Medicine  Columbus Ohio 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