{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T03:51:33Z","timestamp":1791258693527,"version":"4.1.0"},"reference-count":14,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2026,7,9]],"date-time":"2026-07-09T00:00:00Z","timestamp":1783555200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,7,9]],"date-time":"2026-07-09T00:00:00Z","timestamp":1783555200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Transplant Infectious Dis"],"published-print":{"date-parts":[[2026,9]]},"abstract":"ABSTRACT<\/jats:title>\n \n Background and Hypothesis<\/jats:title>\n UK guidance recommends targeted screening for latent tuberculosis infection (LTBI) in kidney transplant candidates based on epidemiological or clinical risk factors, whereas international guidelines favor systematic screening. We aimed to determine whether a targeted screening strategy would miss cases compared with systematic interferon\u2010gamma release assay (IGRA) screening in a UK kidney transplant cohort.<\/jats:p>\n <\/jats:sec>\n \n Methods<\/jats:title>\n We conducted a single\u2010center retrospective cohort study of adult kidney transplant candidates assessed at the Royal Liverpool University Hospital between July 2021 and December 2024. LTBI prevalence was estimated among candidates with definitive IGRA results. Systematic screening was compared with a hypothetical targeted strategy restricted to high\u2010risk candidates, using risk ratios, numbers needed to screen, and diagnostic performance measures. Multivariable logistic regression examined predictors of LTBI positivity.<\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n Of 527 candidates assessed, 465 had definitive IGRA results, including 27 LTBI\u2010positive and 438 LTBI\u2010negative candidates. LTBI prevalence was 5.8% (95% CI 3.9%\u20138.3%). Of 96 high\u2010risk candidates, 17 (17.7%) were LTBI\u2010positive; targeted screening would have missed 10 cases (37.0%; 95% CI 19.4%\u201357.6%) in low\u2010risk candidates and had a sensitivity of 63.0%. In multivariable analysis, LTBI positivity was associated with birth outside the UK, older age, and abnormal chest radiograph. All 22 treated candidates completed therapy with no hepatotoxicity or active TB during follow\u2010up.<\/jats:p>\n <\/jats:sec>\n \n Conclusions<\/jats:title>\n \n Systematic IGRA screening identified LTBI in low\u2010risk kidney transplant candidates who would have been missed by targeted screening. These findings support consideration of routine pretransplant IGRA testing in comparable UK transplant settings, while recognizing the limitations of a single\u2010center, low\u2010prevalence cohort.\n \n \n image<\/jats:alt-text>\n <\/jats:graphic>\n <\/jats:boxed-text>\n <\/jats:p>\n <\/jats:sec>","DOI":"10.1111\/tid.70273","type":"journal-article","created":{"date-parts":[[2026,7,9]],"date-time":"2026-07-09T14:21:03Z","timestamp":1783606863000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["The Impact of Systematic Latent Tuberculosis Infection Screening in Kidney Transplant Candidates: Experience From a Single UK Transplant Center"],"prefix":"10.1111","volume":"28","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6860-2302","authenticated-orcid":false,"given":"Innocent Lule","family":"Segamwenge","sequence":"first","affiliation":[{"name":"University Hospitals of Liverpool Group NHS Trust Liverpool UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hameed","family":"Anijeet","sequence":"additional","affiliation":[{"name":"University Hospitals of Liverpool Group NHS Trust Liverpool UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anirudh","family":"Rao","sequence":"additional","affiliation":[{"name":"University Hospitals of Liverpool Group NHS Trust Liverpool UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Abdul","family":"Hammad","sequence":"additional","affiliation":[{"name":"University Hospitals of Liverpool Group NHS Trust Liverpool UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matthew","family":"Howse","sequence":"additional","affiliation":[{"name":"University Hospitals of Liverpool Group NHS Trust Liverpool UK"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,7,9]]},"reference":[{"key":"e_1_2_12_2_1","doi-asserted-by":"publisher","DOI":"10.1097\/TP.0000000000003136"},{"key":"e_1_2_12_3_1","doi-asserted-by":"publisher","DOI":"10.1097\/TXD.0000000000001672"},{"key":"e_1_2_12_4_1","doi-asserted-by":"publisher","DOI":"10.34172\/npj.2024.11679"},{"key":"e_1_2_12_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/ctr.13513"},{"key":"e_1_2_12_6_1","doi-asserted-by":"publisher","DOI":"10.1136\/thx.2010.144295"},{"key":"e_1_2_12_7_1","volume-title":"Tuberculosis: Prevention, Diagnosis, Management and Service Organisation","year":"2016"},{"key":"e_1_2_12_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jiac.2019.02.018"},{"key":"e_1_2_12_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.humimm.2008.10.005"},{"key":"e_1_2_12_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600\u20106143.2007.02011.x"},{"key":"e_1_2_12_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1399\u20103062.2011.00666.x"},{"key":"e_1_2_12_12_1","unstructured":"Tuberculosis in England: 2025 Report(UK Health Security Agency 2025)."},{"key":"e_1_2_12_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/tid.12476"},{"key":"e_1_2_12_14_1","doi-asserted-by":"publisher","DOI":"10.7861\/clinmedicine.14\u20101\u201026"},{"key":"e_1_2_12_15_1","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/cit488"}],"container-title":["Transplant Infectious Disease"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/tid.70273","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/tid.70273","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/tid.70273","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T03:17:11Z","timestamp":1791256631000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/tid.70273"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,7,9]]},"references-count":14,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2026,9]]}},"alternative-id":["10.1111\/tid.70273"],"URL":"https:\/\/doi.org\/10.1111\/tid.70273","archive":["Portico"],"relation":{},"ISSN":["1398-2273","1399-3062"],"issn-type":[{"value":"1398-2273","type":"print"},{"value":"1399-3062","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,7,9]]},"assertion":[{"value":"2026-04-18","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-06-30","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-07-09","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e70273"}}