{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T04:25:33Z","timestamp":1786940733584,"version":"build-2736575974"},"reference-count":23,"publisher":"Wiley","license":[{"start":{"date-parts":[[2026,8,16]],"date-time":"2026-08-16T00:00:00Z","timestamp":1786838400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,8,16]],"date-time":"2026-08-16T00:00:00Z","timestamp":1786838400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Transplant Infectious Dis"],"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Few studies have examined pretransplant CD4 count and risk of post\u2010kidney transplant (KT) infection in persons with HIV (PWH).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This multi\u2010center, retrospective cohort study included adult PWH undergoing KT from 2004 to 2019. The primary outcome was infection in the first year post\u2010KT in PWH with pretransplant CD4 &lt; 350 cells\/\u00b5L versus CD4 \u2265 350 cells\/\u00b5L. Relative risk was assessed using modified Poisson modeling. Restricted mean survival time analysis was used to assess 5\u2010year posttransplant outcomes.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Of the 75 patients included, 27% had a pretransplant CD4 &lt; 350 cells\/\u00b5L. Those with CD4 &lt; 350\u00a0versus CD4 \u2265 350 were more likely to be hospitalized for infection in the first year (55%\u00a0versus 16%,\n                      <jats:italic>p<\/jats:italic>\n                      = 0.001). There were no significant differences in relative risk of infection in the first\u2010year posttransplant (RR: 1.31,\n                      <jats:italic>p<\/jats:italic>\n                      = 0.053), 5\u2010year overall survival (87.5%\u00a0vs. 93%,\n                      <jats:italic>p<\/jats:italic>\n                      = 0.49) or 5\u2010year graft loss (29.4%\u00a0vs. 23.1%,\n                      <jats:italic>p<\/jats:italic>\n                      = 0.61) betweengroups.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>These findings suggest that pretransplant CD4 count alone may not reflect the true risk of post\u2010KT infection in PWH.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/tid.70290","type":"journal-article","created":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T04:05:53Z","timestamp":1786939553000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["The Association of Pretransplant CD4 Count With Post\u2010Kidney Transplant Infectious Outcomes Among Persons With HIV"],"prefix":"10.1111","author":[{"given":"Rebecca H.","family":"Burns","sequence":"first","affiliation":[{"name":"Division of Infectious Diseases Beth Israel Deaconess Medical Center  Boston Massachusetts USA"},{"name":"Harvard Medical School  Boston Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sara","family":"Booth","sequence":"additional","affiliation":[{"name":"Center for Healthcare Delivery Science Beth Israel Deaconess Medical Center  Boston Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christin Rogers","family":"Marks","sequence":"additional","affiliation":[{"name":"Division of Infectious Diseases Beth Israel Deaconess Medical Center  Boston Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christine M.","family":"Durand","sequence":"additional","affiliation":[{"name":"Johns Hopkins University School of Medicine  Baltimore Maryland USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jonathan","family":"Hand","sequence":"additional","affiliation":[{"name":"Ochsner Health  New Orleans Louisiana USA"},{"name":"Ochsner Clinical School University of Queensland School of Medicine  New Orleans Louisiana USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maheen Z.","family":"Abidi","sequence":"additional","affiliation":[{"name":"Mayo Clinic Arizona  Phoenix Arizona USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maricar","family":"Malinis","sequence":"additional","affiliation":[{"name":"Division of Infectious Diseases Vanderbilt University  Nashville Tennessee USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brittany","family":"Barnaba","sequence":"additional","affiliation":[{"name":"Johns Hopkins University School of Medicine  Baltimore Maryland USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martha","family":"Pavlakis","sequence":"additional","affiliation":[{"name":"Harvard Medical School  Boston Massachusetts USA"},{"name":"Transplant Institute Beth Israel Deaconess Medical Center  Boston Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Douglas","family":"Krakower","sequence":"additional","affiliation":[{"name":"Division of Infectious Diseases Beth Israel Deaconess Medical Center  Boston Massachusetts USA"},{"name":"Harvard Medical School  Boston Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carolyn D.","family":"Alonso","sequence":"additional","affiliation":[{"name":"Division of Infectious Diseases Beth Israel Deaconess Medical Center  Boston Massachusetts USA"},{"name":"Harvard Medical School  Boston Massachusetts USA"},{"name":"Transplant Institute Beth Israel Deaconess Medical Center  Boston Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Audrey","family":"Le\u2010Mahajan","sequence":"additional","affiliation":[{"name":"Division of Infectious Diseases Beth Israel Deaconess Medical Center  Boston Massachusetts USA"},{"name":"Harvard Medical School  Boston Massachusetts USA"},{"name":"Transplant Institute Beth Israel Deaconess Medical Center  Boston Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,8,16]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.7326\/0003\u20104819\u2010139\u20103\u2010200308050\u201000011"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/ciu919"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1097\/SLA.0000000000001761"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/ctr.13499"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1097\/QAI.0000000000001967"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1086\/510746"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1086\/597093"},{"key":"e_1_2_10_9_1","unstructured":"Clinical Info HIV.gov. (2025 September). \u201cSuboptimal CD4 Cell Recovery Despite Viral Suppression. Guidelines for the Use of Antiretroviral Agents in Adults and Adolescents With HIV \u201dhttps:\/\/clinicalinfo.hiv.gov\/en\/guidelines\/hiv\u2010clinical\u2010guidelines\u2010adult\u2010and\u2010adolescent\u2010arv\/suboptimal\u2010cd4\u2010cell\u2010recovery."},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/ajt.13782"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140\u20106736(06)69117\u20104"},{"key":"e_1_2_10_12_1","doi-asserted-by":"crossref","first-page":"951","DOI":"10.1086\/377606","article-title":"When to Begin Highly Active Antiretroviral Therapy? Evidence Supporting Initiation of Therapy at CD4+ Lymphocyte Counts <350 Cells\/microL","volume":"37","author":"Kaplan J. E.","year":"2003","journal-title":"Clinical Infectious Diseases"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM200005043421809"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1053\/ajkd.2002.32793"},{"key":"e_1_2_10_15_1","unstructured":"Clinicalinfo.HIV.gov \"Guidelines for the Prevention and Treatment of Opportunistic Infections in Adults and Adolescents With HIV \" published May 27 2026 https:\/\/clinicalinfo.hiv.gov\/en\/guidelines\/adult\u2010and\u2010adolescent\u2010opportunistic\u2010infection."},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.1111\/tid.14431"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1001197"},{"key":"e_1_2_10_18_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2025.1580369"},{"key":"e_1_2_10_19_1","doi-asserted-by":"publisher","DOI":"10.1111\/tid.14287"},{"key":"e_1_2_10_20_1","doi-asserted-by":"publisher","DOI":"10.1177\/0956462417726213"},{"key":"e_1_2_10_21_1","doi-asserted-by":"publisher","DOI":"10.1681\/ASN.2014070726"},{"key":"e_1_2_10_22_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12879\u2010025\u201011480\u20107"},{"key":"e_1_2_10_23_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamasurg.2021.6798"},{"key":"e_1_2_10_24_1","doi-asserted-by":"publisher","DOI":"10.1093\/ofid\/ofae182"}],"container-title":["Transplant Infectious Disease"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/tid.70290","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/tid.70290","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/tid.70290","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T04:05:55Z","timestamp":1786939555000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/tid.70290"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,8,16]]},"references-count":23,"alternative-id":["10.1111\/tid.70290"],"URL":"https:\/\/doi.org\/10.1111\/tid.70290","archive":["Portico"],"relation":{},"ISSN":["1398-2273","1399-3062"],"issn-type":[{"value":"1398-2273","type":"print"},{"value":"1399-3062","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,8,16]]},"assertion":[{"value":"2026-03-13","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-07-20","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-08-16","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e70290"}}