{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,11]],"date-time":"2026-08-11T09:36:23Z","timestamp":1786440983702,"version":"build-2736575974"},"reference-count":38,"publisher":"Wiley","license":[{"start":{"date-parts":[[2026,8,11]],"date-time":"2026-08-11T00:00:00Z","timestamp":1786406400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,8,11]],"date-time":"2026-08-11T00:00:00Z","timestamp":1786406400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100010455","name":"Swiss Transplant Cohort Study","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100010455","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Transplant Infectious Dis"],"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>In Switzerland, hepatitis E virus (HEV) Genotype 3 is the leading cause of acute viral hepatitis and is mainly transmitted via contaminated pork, but also through solid organ transplantation and blood transfusion. Immunocompromised patients are particularly at risk, as chronic hepatitis may develop. This nationwide cross\u2010sectional study aimed to retrospectively assess HEV epidemiology in SOT and allogeneic hematopoietic stem cell transplant recipients.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>A total of 2942 patients from the Swiss Transplant Cohort Study sampled at transplantation date (T0) and at 1\u2010year follow\u2010up (T12) were tested for anti\u2010HEV IgG and HEV RNA. For seroconverted or HEV RNA\u2010positive patients, further analyses were performed, including characterization of samples collected 6 months posttransplantation (T6). Furthermore, 587 archived blood donor samples were retrospectively examined to investigate their potential role in HEV transmission.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>The anti\u2010HEV IgG seroprevalence of 21.6% at T0 and 19.4% at T12 in transplant recipients was comparable to that of Swiss blood donors. However, the overall incidence of HEV RNA of 1:210 was more than 20\u2010fold higher, with 53% of infections persisting for 6 months or more. Except for one imported genotype 1g case, all infections were of Genotype 3, predominantly subtype 3h3, which is endemic in Switzerland. Notably, a transfusion\u2010transmitted HEV infection was identified.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Given the increased susceptibility of transplant recipients to HEV and their reduced ability to clear the infection, surveillance and dietary advisory measures are crucial to reduce the risk of potentially deleterious outcomes. HEV screening of blood donors should be maintained as an important preventive measure.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/tid.70296","type":"journal-article","created":{"date-parts":[[2026,8,11]],"date-time":"2026-08-11T09:06:16Z","timestamp":1786439176000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Hepatitis E Virus Infection in Swiss Transplant Recipients: Seroprevalence, Incidence, and the Role of Transfused Blood Products"],"prefix":"10.1111","author":[{"ORCID":"https:\/\/orcid.org\/0009-0007-6939-1280","authenticated-orcid":false,"given":"Nadja","family":"Widmer","sequence":"first","affiliation":[{"name":"Interregional Blood Transfusion SRC  Bern Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter","family":"Gowland","sequence":"additional","affiliation":[{"name":"Interregional Blood Transfusion SRC  Bern Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9020-8192","authenticated-orcid":false,"given":"Beat","family":"M\u00fcllhaupt","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Hepatology University Hospital Z\u00fcrich  Z\u00fcrich Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1942-8392","authenticated-orcid":false,"given":"Urs","family":"Schanz","sequence":"additional","affiliation":[{"name":"Department of Medical Oncology and Hematology University Hospital  Zurich Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3556-5522","authenticated-orcid":false,"given":"Soraya","family":"Amar","sequence":"additional","affiliation":[{"name":"National Blood Transfusion Service of the Swiss Red Cross  Bern 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Biomedicine University of Basel  Basel Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7870-912X","authenticated-orcid":false,"given":"C\u00e9dric","family":"Hirzel","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases Inselspital, Bern University Hospital University of Bern  Bern Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1977-6792","authenticated-orcid":false,"given":"Darius","family":"Moradpour","sequence":"additional","affiliation":[{"name":"Service of Gastroenterology and Hepatology Lausanne University Hospital (CHUV) University of Lausanne  Lausanne Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1059-3191","authenticated-orcid":false,"given":"Nicolas J.","family":"Mueller","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases and Hospital Epidemiology University Hospital Z\u00fcrich University of Z\u00fcrich  Z\u00fcrich Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Simona","family":"Rossi","sequence":"additional","affiliation":[{"name":"Clinic for Transplantation Immunology and Nephrology Basel University Hospital  Basel Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9170-1341","authenticated-orcid":false,"given":"Stefan","family":"Schaub","sequence":"additional","affiliation":[{"name":"Clinic for Transplantation Immunology and Nephrology Basel University Hospital  Basel Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3447-264X","authenticated-orcid":false,"given":"Guido","family":"Stirnimann","sequence":"additional","affiliation":[{"name":"University Clinic for Visceral Surgery and Medicine University Hospital Inselspital, University of Bern  Bern 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