{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,16]],"date-time":"2026-03-16T13:31:59Z","timestamp":1773667919335,"version":"3.50.1"},"reference-count":30,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2013,3,1]],"date-time":"2013-03-01T00:00:00Z","timestamp":1362096000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Transfusion Medicine"],"published-print":{"date-parts":[[2013,4]]},"abstract":"<jats:title>Summary<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>The aims of our study were to evaluate (i) the relationship between cardiac <jats:styled-content style=\"fixed-case\">T2<\/jats:styled-content>* values and cardiac complications in Asian \u03b2\u2010thalassaemia major (<jats:styled-content style=\"fixed-case\">TM<\/jats:styled-content>) patients, and (ii) the association between cardiac <jats:styled-content style=\"fixed-case\">T2<\/jats:styled-content>* values and other parameters currently used to predict cardiac complications as a result of transfusion iron overload.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We examined the myocardial iron loads of 88 <jats:styled-content style=\"fixed-case\">TM<\/jats:styled-content> patients from Taiwan with cardiac <jats:styled-content style=\"fixed-case\">T2<\/jats:styled-content>* magnetic resonance imaging (<jats:styled-content style=\"fixed-case\">MRI<\/jats:styled-content>) and assessed the correlation between cardiac <jats:styled-content style=\"fixed-case\">T2<\/jats:styled-content>* values and serum ferritin levels, liver iron concentration and left ventricular ejection fraction (<jats:styled-content style=\"fixed-case\">LVEF<\/jats:styled-content>). We also determined the predictive value of these measurements for the development of arrhythmia.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results and conclusion<\/jats:title><jats:p>In our group of Taiwanese patients, the relative risk for arrhythmia was 10\u00b736 when cardiac <jats:styled-content style=\"fixed-case\">T2<\/jats:styled-content>* values were less than 10\u2009ms (compared with \u226510\u2009ms) and 1\u00b798 when serum ferritin levels increased &gt;2500\u2009ng mL<jats:sup>\u22121<\/jats:sup> (compared with \u22642500\u2009ng mL<jats:sup>\u22121<\/jats:sup>). Serum ferritin levels correlated with cardiac <jats:styled-content style=\"fixed-case\">T2<\/jats:styled-content>* values in patients with abnormal myocardial iron loads (<jats:styled-content style=\"fixed-case\">T2<\/jats:styled-content>*\u2009&lt;\u200920\u2009ms, <jats:italic>r<\/jats:italic>\u2009=\u2009\u22120\u00b748, <jats:italic>P<\/jats:italic>\u2009=\u20090\u00b7004, <jats:italic>n<\/jats:italic> = 34), but <jats:styled-content style=\"fixed-case\">LVEF<\/jats:styled-content> (measured by echocardiography) gave no indication of excess myocardial iron deposition (<jats:italic>r<\/jats:italic>\u2009=\u2009\u22120\u00b707, <jats:italic>P<\/jats:italic>\u2009=\u20090\u00b752) or of the risk of developing arrhythmia.<\/jats:p><\/jats:sec>","DOI":"10.1111\/tme.12014","type":"journal-article","created":{"date-parts":[[2013,3,2]],"date-time":"2013-03-02T00:54:46Z","timestamp":1362185686000},"page":"100-107","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":14,"title":["Cardiac iron measurement and iron chelation therapy in patients with \u03b2 thalassaemia major: experience from Taiwan"],"prefix":"10.1111","volume":"23","author":[{"given":"M. \u2010Y.","family":"Lu","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S. 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