{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,26]],"date-time":"2026-06-26T04:31:49Z","timestamp":1782448309201,"version":"3.54.5"},"reference-count":28,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2013,3,1]],"date-time":"2013-03-01T00:00:00Z","timestamp":1362096000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Transfusion Medicine"],"published-print":{"date-parts":[[2013,4]]},"abstract":"<jats:title>Summary<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>To study the clinical usefulness of maternal anti\u2010<jats:styled-content style=\"fixed-case\">HPA<\/jats:styled-content>\u20101a antibody levels in predicting severe foetomaternal alloimmune thrombocytopenia (<jats:styled-content style=\"fixed-case\">FMAIT<\/jats:styled-content>).<\/jats:p><\/jats:sec><jats:sec><jats:title>Background<\/jats:title><jats:p>Recent studies using an international anti\u2010<jats:styled-content style=\"fixed-case\">HPA<\/jats:styled-content>\u20101a standard have shown a correlation between maternal antibody levels and neonatal thrombocytopenia. Cut\u2010off values for identifying high\u2010risk pregnancies have also been suggested.<\/jats:p><\/jats:sec><jats:sec><jats:title>Materials<\/jats:title><jats:p>In 1986\u20132010, <jats:styled-content style=\"fixed-case\">HPA<\/jats:styled-content>\u20101a alloimmunisation was confirmed in 84 women with 129 pregnancies. Maternal samples were obtained at delivery and during subsequent pregnancies. Anti\u2010<jats:styled-content style=\"fixed-case\">HPA<\/jats:styled-content>\u20101a was quantified using a <jats:styled-content style=\"fixed-case\">MAIPA<\/jats:styled-content> assay with a detection limit of 0\u00b78 <jats:styled-content style=\"fixed-case\">IU mL<\/jats:styled-content><jats:sup>\u20101<\/jats:sup> (<jats:styled-content style=\"fixed-case\">WHO<\/jats:styled-content> reference serum 03\/152). Antibody levels were compared with the severity of neonatal disease in the index and in the subsequent pregnancies.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>In the index cases, the correlation between an anti\u2010<jats:styled-content style=\"fixed-case\">HPA<\/jats:styled-content>\u20101a level and neonatal platelet count did not reach statistical significance (<jats:italic>n<\/jats:italic>\u2009=\u200977, <jats:italic>P<\/jats:italic>\u2009=\u20090\u00b7074). However, the platelet counts and antibody levels in cases with cutaneous (<jats:italic>n<\/jats:italic>\u2009=\u200945) or intracranial haemorrhage (<jats:italic>n<\/jats:italic>\u2009=\u20097) were significantly different from cases with no evidence of bleeding (<jats:italic>n<\/jats:italic>\u2009=\u200920). In the subsequent pregnancies, there was a stronger association between the second trimester anti\u2010<jats:styled-content style=\"fixed-case\">HPA<\/jats:styled-content>\u20101a level and the foetal platelet count (<jats:italic>n<\/jats:italic>\u2009=\u200916, <jats:italic>P<\/jats:italic>\u2009=\u20090\u00b7046). The positive predictive value of the maternal antibody level for a foetal platelet count &lt;20 \u00d7 10<jats:sup>9<\/jats:sup> L<jats:sup>\u20101<\/jats:sup> was 90%, but the negative predictive value only 31%.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Although a higher anti\u2010<jats:styled-content style=\"fixed-case\">HPA<\/jats:styled-content>\u20101a level correlated with a more severe neonatal disease, barely detectable antibody levels were also observed in severely affected pregnancies. Cut\u2010off values with sufficient sensitivity and specificity to identify these foetuses could not be found. A previous obstetric history still remains the most useful predictive parameter for severe <jats:styled-content style=\"fixed-case\">FMAIT<\/jats:styled-content> in clinical practice.<\/jats:p><\/jats:sec>","DOI":"10.1111\/tme.12018","type":"journal-article","created":{"date-parts":[[2013,3,2]],"date-time":"2013-03-02T00:36:59Z","timestamp":1362184619000},"page":"114-120","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":19,"title":["Usefulness of maternal anti\u2010<scp>HPA<\/scp>\u20101a antibody quantitation in predicting severity of foetomaternal alloimmune thrombocytopenia"],"prefix":"10.1111","volume":"23","author":[{"given":"S.","family":"Sainio","sequence":"first","affiliation":[{"name":"Finnish Red Cross Blood Service Platelet Immunology laboratory  Helsinki Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"K.","family":"Javela","sequence":"additional","affiliation":[{"name":"Finnish Red Cross Blood Service Platelet Immunology laboratory  Helsinki Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.","family":"Tuimala","sequence":"additional","affiliation":[{"name":"Finnish Red Cross Blood Service Platelet Immunology laboratory  Helsinki Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S.","family":"Koskinen","sequence":"additional","affiliation":[{"name":"Finnish Red Cross Blood Service Platelet Immunology laboratory  Helsinki 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