{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,8,27]],"date-time":"2025-08-27T15:46:04Z","timestamp":1756309564779},"reference-count":23,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2013,4,25]],"date-time":"2013-04-25T00:00:00Z","timestamp":1366848000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Transfusion Medicine"],"published-print":{"date-parts":[[2013,8]]},"abstract":"<jats:title>SUMMARY<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Alloantibodies against human platelet antigens (<jats:styled-content style=\"fixed-case\">HPAs<\/jats:styled-content>) are responsible for the development of alloimmune thrombocytopenia including platelet transfusion refractoriness (<jats:styled-content style=\"fixed-case\">PTR<\/jats:styled-content>) and neonatal alloimmune thrombocytopenia (<jats:styled-content style=\"fixed-case\">NAIT<\/jats:styled-content>). Therefore, transfusion of <jats:italic><jats:styled-content style=\"fixed-case\">HPA<\/jats:styled-content>\u2010compatible<\/jats:italic> platelets is of importance for the management of these diseases.<\/jats:p><\/jats:sec><jats:sec><jats:title>Aim<\/jats:title><jats:p>Determination of the allele frequency of the major <jats:styled-content style=\"fixed-case\">HPA<\/jats:styled-content> systems for Indonesian blood donors and the development of the first <jats:styled-content style=\"fixed-case\">HPA<\/jats:styled-content>\u2010typed donor registry in Indonesia.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p><jats:styled-content style=\"fixed-case\">DNA<\/jats:styled-content> derived from 500 Indonesian healthy blood donors was genotyped for <jats:styled-content style=\"fixed-case\">HPA<\/jats:styled-content>\u20101 to <jats:styled-content style=\"fixed-case\">HPA<\/jats:styled-content>\u20106 and <jats:styled-content style=\"fixed-case\">HPA<\/jats:styled-content>\u201015 alleles by the use of polymerase chain reaction sequence\u2010specific primer method.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The gene frequencies of the rare allelic variants <jats:styled-content style=\"fixed-case\">HPA<\/jats:styled-content>\u20101b, \u20102b, \u20103b, \u20104b, \u20105b, \u20106b and \u201015b were 0\u00b7023, 0\u00b7060, 0\u00b7493, 0\u00b7052, 0\u00b7032, 0\u00b7044 and 0\u00b7049, respectively. However, donors homozygous for the <jats:styled-content style=\"fixed-case\">HPA<\/jats:styled-content>\u20101b, \u20102b and \u20106b were not found in this cohort, indicating that the risks of <jats:italic>alloimmunisation<\/jats:italic> caused by incompatibility of these three <jats:styled-content style=\"fixed-case\">HPA<\/jats:styled-content> systems are extremely low. In contrast, <jats:italic>alloimmunisation<\/jats:italic> against <jats:styled-content style=\"fixed-case\">HPA<\/jats:styled-content>\u20103, \u20104, \u20105 and \u201015 systems is <jats:italic>anticipated<\/jats:italic>.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>The development of an <jats:styled-content style=\"fixed-case\">HPA<\/jats:styled-content>\u2010genotyped registry for donors homozygous for <jats:styled-content style=\"fixed-case\">HPA<\/jats:styled-content>\u20101b, \u20102b and \u20106b is desired for the optimum management of <jats:styled-content style=\"fixed-case\">PTR<\/jats:styled-content> patients and children with <jats:styled-content style=\"fixed-case\">NAIT<\/jats:styled-content>.<\/jats:p><\/jats:sec>","DOI":"10.1111\/tme.12039","type":"journal-article","created":{"date-parts":[[2013,4,26]],"date-time":"2013-04-26T04:01:50Z","timestamp":1366948910000},"page":"250-253","update-policy":"http:\/\/dx.doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["Human platelet\u2010specific antigen frequencies in Indonesian population"],"prefix":"10.1111","volume":"23","author":[{"family":"Asmarinah","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R.","family":"Dharma","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"N. 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