{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,5]],"date-time":"2026-02-05T08:21:32Z","timestamp":1770279692829,"version":"3.49.0"},"reference-count":46,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2013,7,5]],"date-time":"2013-07-05T00:00:00Z","timestamp":1372982400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Transfusion Medicine"],"published-print":{"date-parts":[[2013,10]]},"abstract":"<jats:title>SUMMARY<\/jats:title><jats:sec><jats:title>Background\/Objectives<\/jats:title><jats:p>Blood donors attending a donation session may be deemed ineligible to donate blood due to a failure to meet low haemoglobin (Hb) thresholds. Several studies have identified factors associated with a donor falling below these Hb thresholds. A review of these factors will inform future prospective studies and form the basis for predictive models of deferral due to low Hb.<\/jats:p><\/jats:sec><jats:sec><jats:title>Materials\/Methods<\/jats:title><jats:p>Studies were identified by searching <jats:styled-content style=\"fixed-case\">MEDLINE<\/jats:styled-content>, <jats:styled-content style=\"fixed-case\">EMBASE<\/jats:styled-content>, <jats:italic>The Cochrane Library<\/jats:italic> and the <jats:styled-content style=\"fixed-case\">WHO<\/jats:styled-content> International Clinical Trials Registry from 1980 to September 2012. Demographic data, donor history, haematological\/biological factors and the primary outcome of deferral due to low Hb were extracted. Analyses were descriptive and quantitative; pooled odds ratios (ORs) were obtained by meta\u2010analysis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Fifty\u2010five studies met the inclusion criteria. A consistently higher rate of low Hb deferral was reported in females compared with males; meta\u2010analysis showed a significantly greater risk of deferral due to low Hb in females compared with males in studies with universal Hb thresholds for males and females (<jats:styled-content style=\"fixed-case\">OR<\/jats:styled-content> 14\u00b791, 95% confidence interval (<jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content>) 12\u00b782\u201317\u00b734) and in studies with sex\u2010specific Hb thresholds (<jats:styled-content style=\"fixed-case\">OR<\/jats:styled-content> 8\u00b719, 95% <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content> 4\u00b788\u201313\u00b774). Greater rates of deferral due to low Hb were also associated with increasing age, higher ambient temperature, low body weight, shorter inter\u2010donation interval and in donors of Hispanic or African descent.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>This work will help to define the criteria that should be considered in any large scale study of blood donor deferral, especially those that measure or aim to change failure to meet low Hb thresholds.<\/jats:p><\/jats:sec>","DOI":"10.1111\/tme.12046","type":"journal-article","created":{"date-parts":[[2013,7,5]],"date-time":"2013-07-05T13:34:39Z","timestamp":1373031279000},"page":"309-320","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":24,"title":["A systematic review of factors associated with the deferral of donors failing to meet low haemoglobin thresholds"],"prefix":"10.1111","volume":"23","author":[{"given":"Graham A.","family":"Smith","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sheila A.","family":"Fisher","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Carolyn","family":"Dor\u00e9e","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David J.","family":"Roberts","sequence":"additional","affiliation":[{"name":"Nuffield Department of Clinical Laboratory Sciences John Radcliffe Hospital  Headington Oxford UK"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2013,7,5]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.4103\/0973-6247.67035"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-3148.2007.00738.x"},{"key":"e_1_2_7_4_1","unstructured":"ASH: action on smoking and health (2007)Tobacco: Global Trends. URLhttp:\/\/www.ash.org.uk\/files\/documents\/ASH_562.pdf(Accessed 30\/10\/12)."},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1423-0410.2010.01382.x"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1537-2995.2012.03655.x"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2005-07-3046"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpendo.2001.281.6.E1172"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1537-2995.2002.00103.x"},{"key":"e_1_2_7_10_1","volume-title":"Guide to the Preparation, Use and Quality Assurance of Blood Components","author":"Council of Europe.","year":"2010"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1537-2995.2004.04160.x"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1537-2995.2007.01292.x"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1537-2995.2011.03353.x"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1537-2995.2008.02062.x"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tmrv.2009.03.003"},{"key":"e_1_2_7_16_1","unstructured":"European Vegetarian Society(2012)How Many Veggies\u2026?URLhttp:\/\/www.euroveg.eu\/lang\/en\/info\/howmany.php(Accessed 30\/10\/12)."},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V50.3.441.441"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1537-2995.2011.03533.x"},{"key":"e_1_2_7_19_1","first-page":"47","article-title":"Pre\u2010donation deferral of whole blood donors in district transfusion centre","volume":"6","author":"Girish C.J.","year":"2012","journal-title":"Journal of Clinical and Diagnostic Research"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1537-2995.2012.03820.x"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.1080\/08880010500456907"},{"key":"e_1_2_7_22_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2004-05-1812"},{"key":"e_1_2_7_23_1","doi-asserted-by":"publisher","DOI":"10.1182\/asheducation-2005.1.528"},{"key":"e_1_2_7_24_1","doi-asserted-by":"publisher","DOI":"10.1186\/1750-1172-5-13"},{"key":"e_1_2_7_25_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1537-2995.2010.02881.x"},{"key":"e_1_2_7_26_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1537-2995.2007.01207.x"},{"key":"e_1_2_7_27_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1537-2995.2012.03756.x"},{"key":"e_1_2_7_28_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1537-2995.1988.28689059031.x"},{"key":"e_1_2_7_29_1","first-page":"326","article-title":"Main causes of pre\u2010donation deferral of prospective blood donors in the Singapore Blood Transfusion Service","volume":"22","author":"Lim J.C.","year":"1993","journal-title":"Annals of the Academy of Medicine"},{"key":"e_1_2_7_30_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1537-2995.2008.01823.x"},{"key":"e_1_2_7_31_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1537-2995.2010.02649.x"},{"key":"e_1_2_7_32_1","unstructured":"NHSBT(2010)Annual Report. URLhttp:\/\/www.nhsbt.nhs.uk\/annualreview\/progress\u201009\u201010\/blood\u2010components(Accessed 18\/2\/11)."},{"key":"e_1_2_7_33_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.0954-6820.1988.tb19632.x"},{"key":"e_1_2_7_34_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-3148.2011.01110.x"},{"key":"e_1_2_7_35_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-3148.2009.00979.x"},{"key":"e_1_2_7_36_1","unstructured":"Review Manager (RevMan). (2011) [computer program]. The Nordic Cochrane Centre The Cochrane Collaboration Copenhagen."},{"key":"e_1_2_7_37_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1537-2995.2007.01206.x"},{"key":"e_1_2_7_38_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1537-2995.2009.02501.x"},{"key":"e_1_2_7_39_1","doi-asserted-by":"publisher","DOI":"10.4103\/0973-6247.67037"},{"key":"e_1_2_7_40_1","doi-asserted-by":"publisher","DOI":"10.1002\/jca.20171"},{"key":"e_1_2_7_41_1","volume-title":"Guidelines for the Blood Transfusion Services in the UK","author":"United Kingdom Blood Transfusion Services.","year":"2005"},{"key":"e_1_2_7_42_1","unstructured":"US Food and Drug Administration.(2008)Recommendations of the Advisory Committee on Blood Safety and Availability. URLhttp:\/\/www.hhs.gov\/ash\/bloodsafety\/advisorycommittee\/recommendations\/resdec08.pdf(Accessed 30\/11\/12)"},{"key":"e_1_2_7_43_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2141.1958.tb03840.x"},{"key":"e_1_2_7_44_1","first-page":"115","article-title":"Haemoglobin levels in blood donor volunteers\u2014a 20\u2010year survey","volume":"75","author":"Wilkinson J.L.","year":"1982","journal-title":"Irish Medical Journal"},{"key":"e_1_2_7_45_1","unstructured":"Yadav Y. &Kumar S.(2006) The food habits of a nation.The Hindu (online) 14 August 2006. URLhttp:\/\/www.hindu.com\/2006\/08\/14\/stories\/2006081403771200.htm(Accessed 23\/12\/11)."},{"key":"e_1_2_7_46_1","first-page":"131","article-title":"Monitoringhemoglobin and iron status in blood donors to prevent iron deficiency","author":"Zanella A.","year":"1989","journal-title":"Bibliotheca Nutritio et Dieta"},{"key":"e_1_2_7_47_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1537-2995.2006.01049.x"}],"container-title":["Transfusion Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Ftme.12046","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/tme.12046","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,29]],"date-time":"2023-09-29T12:49:54Z","timestamp":1695991794000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/tme.12046"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,7,5]]},"references-count":46,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2013,10]]}},"alternative-id":["10.1111\/tme.12046"],"URL":"https:\/\/doi.org\/10.1111\/tme.12046","archive":["Portico"],"relation":{},"ISSN":["0958-7578","1365-3148"],"issn-type":[{"value":"0958-7578","type":"print"},{"value":"1365-3148","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013,7,5]]},"assertion":[{"value":"2013-01-15","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2013-04-23","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2013-07-05","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}