{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,11]],"date-time":"2026-01-11T03:14:56Z","timestamp":1768101296584,"version":"3.49.0"},"reference-count":22,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2013,7,10]],"date-time":"2013-07-10T00:00:00Z","timestamp":1373414400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Transfusion Medicine"],"published-print":{"date-parts":[[2013,10]]},"abstract":"<jats:title>SUMMARY<\/jats:title><jats:sec><jats:title>Objectives<\/jats:title><jats:p>To construct an alternative policy for the donor selection of platelet concentrate (<jats:styled-content style=\"fixed-case\">PC<\/jats:styled-content>), a clinical study exploring the features of lung injury following <jats:styled-content style=\"fixed-case\">PC<\/jats:styled-content> administration is needed.<\/jats:p><\/jats:sec><jats:sec><jats:title>Background<\/jats:title><jats:p>Although a male\u2010donor\u2010only policy for plasma products appears to have efficiently reduced transfusion\u2010related acute lung injury (<jats:styled-content style=\"fixed-case\">TRALI<\/jats:styled-content>), this policy may not be applied to <jats:styled-content style=\"fixed-case\">PC<\/jats:styled-content> because of supply shortages.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods and Materials<\/jats:title><jats:p>We prospectively examined pulmonary function after the transfusion of <jats:styled-content style=\"fixed-case\">PC<\/jats:styled-content> in informed surgical patients treated at a tertiary university hospital in Japan. The contributions of immunoreactive substances contained in the <jats:styled-content style=\"fixed-case\">PC<\/jats:styled-content> to respiratory function after <jats:styled-content style=\"fixed-case\">PC<\/jats:styled-content> transfusion was then statistically examined.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Eighty\u2010six patients (56 men, 30 women) were enrolled in the analysis. Fifty\u2010four cases experienced respiratory failure (<jats:styled-content style=\"fixed-case\">PaO<jats:sub>2<\/jats:sub><\/jats:styled-content>\/<jats:styled-content style=\"fixed-case\">FiO<jats:sub>2<\/jats:sub><\/jats:styled-content> &lt;300\u2009mmHg) after transfusion. Five cases were diagnosed as possible <jats:styled-content style=\"fixed-case\">TRALI<\/jats:styled-content> based on permeability pulmonary oedema, while 23 cases were diagnosed as transfusion\u2010associated circulatory overload (<jats:styled-content style=\"fixed-case\">TACO<\/jats:styled-content>) based on chest radiograph findings. A multivariate logistic regression analysis identified the presence of anti\u2010granulocyte antibody as a significant predictor of possible <jats:styled-content style=\"fixed-case\">TRALI<\/jats:styled-content> [<jats:italic>P<\/jats:italic>\u2009=\u20090\u00b7023; odds ratio (<jats:styled-content style=\"fixed-case\">OR<\/jats:styled-content>), 13\u00b70; 95% confidence interval (<jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content>), 1\u00b74\u2013118\u00b73]. Meanwhile, anti\u2010leukocyte antibody class <jats:styled-content style=\"fixed-case\">II<\/jats:styled-content> was identified as a significant independent predictor of <jats:styled-content style=\"fixed-case\">TACO<\/jats:styled-content> (<jats:italic>P<\/jats:italic>\u2009=\u20090\u00b7010; <jats:styled-content style=\"fixed-case\">OR<\/jats:styled-content>, 18\u00b74; 95% <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content>, 2\u00b70\u2013170\u00b71).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Our data suggest that antibodies contained in <jats:styled-content style=\"fixed-case\">PC<\/jats:styled-content> may contribute to the deterioration of respiratory function after <jats:styled-content style=\"fixed-case\">PC<\/jats:styled-content> transfusion, although the diagnoses of <jats:styled-content style=\"fixed-case\">TACO<\/jats:styled-content> and <jats:styled-content style=\"fixed-case\">TRALI<\/jats:styled-content> may have overlapped among the patients with pulmonary distress in this cohort.<\/jats:p><\/jats:sec>","DOI":"10.1111\/tme.12056","type":"journal-article","created":{"date-parts":[[2013,7,10]],"date-time":"2013-07-10T12:01:45Z","timestamp":1373457705000},"page":"344-350","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":14,"title":["Impact of immunoreactive substances contained in apheresis platelet concentrate on postoperative respiratory function in surgical patients receiving platelet transfusion: a prospective cohort study"],"prefix":"10.1111","volume":"23","author":[{"given":"R.","family":"Kanai","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"T.","family":"Iijima","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S.","family":"Hashimoto","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"H.","family":"Nakazawa","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"H.","family":"Ohnishi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"T.","family":"Yorozu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R.","family":"Ohkawa","sequence":"additional","affiliation":[{"name":"Department of Clinical Laboratory Hospital University of Tokyo  Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"T.","family":"Nojiri","sequence":"additional","affiliation":[{"name":"Department of Clinical Laboratory Hospital University of Tokyo  Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.","family":"Shimizu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"H.","family":"Okazaki","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2013,7,10]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1164\/ajrccm.157.4.ats2-98"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1537-2995.2010.02748.x"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1537-2995.2007.01102.x"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1537-2995.2010.02652.x"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1097\/00003246-200108000-00002"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1537-2995.2010.02589.x"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.CCM.0000214311.56231.23"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.200702-271OC"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1537-2995.2008.02090.x"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0009-9120(02)00327-2"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.0041-1132.2004.04347.x"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1378\/chest.09-0841"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbamem.2006.09.026"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1537-2995.2009.02321.x"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1537-2995.2001.41030317.x"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1537-2995.2006.00930.x"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2012.5669"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1537-2995.1997.37797369448.x"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI1841"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1537-2995.2011.03186.x"},{"key":"e_1_2_7_22_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2011-08-370932"},{"key":"e_1_2_7_23_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2010-10-313973"}],"container-title":["Transfusion 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