{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,2]],"date-time":"2026-09-02T10:55:28Z","timestamp":1788346528100,"version":"build-2803163510"},"reference-count":44,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2013,9,4]],"date-time":"2013-09-04T00:00:00Z","timestamp":1378252800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Transfusion Medicine"],"published-print":{"date-parts":[[2013,12]]},"abstract":"<jats:title>SUMMARY<\/jats:title><jats:p>The decades around the turn of the 19th into the 20th centuries covered a seminal period in the history of transfusion medicine as there was an increasing appreciation of a potential role in the management of surgical and obstetric bleeding, and also in severe non\u2010surgical anaemias. The main obstacles to transfusing human blood were first the occasional devastating adverse reactions due, we now know, to <jats:styled-content style=\"fixed-case\">ABO<\/jats:styled-content> blood group incompatibility; and second the awkward propensity of shed blood to clot. This article describes in more detail how the pioneers in human transfusion immunology in the late 19th century and early 20th century learnt to recognise and avoid <jats:styled-content style=\"fixed-case\">ABO<\/jats:styled-content> incompatibility, and includes some hitherto obscure and rarely cited material. A companion article (Boulton, 2013, Submitted for publication) describes early attempts to find suitable anticoagulants.<\/jats:p>","DOI":"10.1111\/tme.12075","type":"journal-article","created":{"date-parts":[[2013,9,4]],"date-time":"2013-09-04T14:04:41Z","timestamp":1378303481000},"page":"375-381","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Blood transfusion; additional historical aspects. Part 1. The birth of transfusion immunology"],"prefix":"10.1111","volume":"23","author":[{"given":"F. E.","family":"Boulton","sequence":"first","affiliation":[{"name":"NHS BT Southampton UK"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2013,9,4]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1113\/expphysiol.1908.sp000023"},{"key":"e_1_2_9_3_1","first-page":"38","article-title":"Coagulation time of the blood in disease","volume":"5","author":"Addis T.","year":"1910","journal-title":"Edinburgh Medical Journal"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/path.1700150402"},{"key":"e_1_2_9_5_1","unstructured":"Austrian Red Cross.Blood Donor Information. Old roteskreuzat. (2006) URLhttp:\/\/www.roteskreuz.at\/(Accessed April 2013)."},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/0035-9203(87)90302-6"},{"key":"e_1_2_9_7_1","unstructured":"BoultonF.(2010)Still counting: the life times and continuing influence of Dr Thomas Addis MD. Sessions of York. 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