{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T07:01:56Z","timestamp":1790146916633,"version":"4.0.1"},"reference-count":41,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2014,1,21]],"date-time":"2014-01-21T00:00:00Z","timestamp":1390262400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Transfusion Medicine"],"published-print":{"date-parts":[[2014,2]]},"abstract":"<jats:title>SUMMARY<\/jats:title><jats:p>The new <jats:styled-content style=\"fixed-case\">British Committee for Standards in Haematology (BCSH)<\/jats:styled-content> guidelines for the use of anti\u2010D immunoglobulin in pregnancy provide a welcome clarification of the use of anti\u2010D in ectopic pregnancy and after red cell salvage during caesarean section, of dosing with different preparations and distinguishing non\u2010immune and immune anti\u2010D. The routine use of anti\u2010D prophylaxis (<jats:styled-content style=\"fixed-case\">RAADP<\/jats:styled-content>) to prevent Rhesus (Rh) D alloimmunisation during the third trimester is well established and requires careful and well\u2010audited local implementation to achieve the maximum public health benefit. In the <jats:styled-content style=\"fixed-case\">UK<\/jats:styled-content>, such scrutiny may be provided by the reporting of failed anti\u2010D prophylaxis at women who have produced an immune anti\u2010D that is detectable for the first time in the current pregnancy through the voluntary Serious Hazards of Transfusion reporting scheme (<jats:styled-content style=\"fixed-case\">SHOT<\/jats:styled-content>). Application of fetal <jats:italic><jats:styled-content style=\"fixed-case\">RHD<\/jats:styled-content><\/jats:italic> genotyping would avoid giving anti\u2010D to <jats:styled-content style=\"fixed-case\">RhD<\/jats:styled-content> negative women carrying an <jats:styled-content style=\"fixed-case\">RhD<\/jats:styled-content> negative fetus. <jats:styled-content style=\"fixed-case\">RAADP<\/jats:styled-content> is directed by fetal <jats:italic><jats:styled-content style=\"fixed-case\">RHD<\/jats:styled-content><\/jats:italic> genotyping in some countries in Northern Europe led by the Netherlands and Denmark. The economic case for <jats:styled-content style=\"fixed-case\">RAADP<\/jats:styled-content> directed by fetal <jats:italic><jats:styled-content style=\"fixed-case\">RHD<\/jats:styled-content><\/jats:italic> genotyping needs to be carefully evaluated and in England is under consideration by National Institute for Health and Clinical Excellence (<jats:styled-content style=\"fixed-case\">NICE<\/jats:styled-content>). Possible future developments include the use of monoclonal anti\u2010D preparations, now in advanced clinical trials, and also testing the hypothesis that directed <jats:styled-content style=\"fixed-case\">RAADP<\/jats:styled-content> from early in the second trimester may further reduce anti\u2010D immunisation.<\/jats:p>","DOI":"10.1111\/tme.12099","type":"journal-article","created":{"date-parts":[[2014,1,21]],"date-time":"2014-01-21T07:44:35Z","timestamp":1390290275000},"page":"1-7","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":63,"title":["Anti\u2010D prophylaxis: past, present and future"],"prefix":"10.1111","volume":"24","author":[{"given":"M.","family":"de Haas","sequence":"first","affiliation":[{"name":"Department of Immunohaematology, Division of Diagnostic Services Sanquin Amsterdam the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"K.","family":"Finning","sequence":"additional","affiliation":[{"name":"National Health Service Blood and Transplant Bristol UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"E.","family":"Massey","sequence":"additional","affiliation":[{"name":"National Health Service Blood and Transplant Bristol UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D. 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