{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,22]],"date-time":"2026-07-22T02:00:28Z","timestamp":1784685628796,"version":"3.55.0"},"reference-count":12,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2014,9,17]],"date-time":"2014-09-17T00:00:00Z","timestamp":1410912000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Transfusion Medicine"],"published-print":{"date-parts":[[2014,10]]},"abstract":"<jats:title>SUMMARY<\/jats:title><jats:sec><jats:title>Objectives<\/jats:title><jats:p>To analyse the incidence of additional alloantibody formation following intrauterine red cell transfusion and to evaluate the feasibility of providing extended phenotype\u2010matched red cells in future intrauterine transfusion (IUT).<\/jats:p><\/jats:sec><jats:sec><jats:title>Background<\/jats:title><jats:p>IUT is performed in severe, life\u2010threatening fetal anaemia, usually in alloimmunised pregnancies. Its complications include the formation of additional alloantibodies to other red cell antigens.<\/jats:p><\/jats:sec><jats:sec><jats:title>Materials and methods<\/jats:title><jats:p>This was an 11\u2010year retrospective, observational study of additional alloantibody formation in patients receiving IUT in the National Maternity Hospital, Dublin. The study included evaluation of the donor population in the Republic of Ireland (RoI) with regards to the feasibility of providing extended phenotype\u2010matched units in future IUT.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Following IUT, 22% of mothers formed additional red cell alloantibodies. In 67% of cases, the transfused donor red cells expressed the cognate antigen. Suitable donors are available for most combinations of Fy, Jk and Ss antigens.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>In our population, it is feasible to provide more extensively phenotype\u2010matched red cells for future IUT. These can be supplied from the current donor pool with no significant extra phenotyping required. We consider their provision to be a reasonable proactive step in a known at\u2010risk group.<\/jats:p><\/jats:sec>","DOI":"10.1111\/tme.12145","type":"journal-article","created":{"date-parts":[[2014,9,17]],"date-time":"2014-09-17T12:48:22Z","timestamp":1410958102000},"page":"311-315","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["Red cell alloimmunisation following intrauterine transfusion and the feasibility of providing extended phenotype\u2010matched red cell units"],"prefix":"10.1111","volume":"24","author":[{"given":"B.","family":"Doyle","sequence":"first","affiliation":[{"name":"Red Cell Immunohaematology Laboratory Irish Blood Transfusion Service"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.","family":"Quigley","sequence":"additional","affiliation":[{"name":"Department of Transfusion Medicine National Maternity Hospital"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Lambert","sequence":"additional","affiliation":[{"name":"Red Cell Immunohaematology Laboratory Irish Blood Transfusion Service"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.","family":"Crumlish","sequence":"additional","affiliation":[{"name":"Red Cell Immunohaematology Laboratory Irish Blood Transfusion Service"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C.","family":"Walsh","sequence":"additional","affiliation":[{"name":"Department of Fetal Medicine National Maternity Hospital"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S.","family":"Adshead","sequence":"additional","affiliation":[{"name":"Automated Donor Grouping Laboratory Irish Blood Transfusion Service  Dublin Ireland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Woolfson","sequence":"additional","affiliation":[{"name":"Red Cell Immunohaematology Laboratory Irish Blood Transfusion Service"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P.","family":"McParland","sequence":"additional","affiliation":[{"name":"Department of Fetal Medicine National Maternity Hospital"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Culliton","sequence":"additional","affiliation":[{"name":"Department of Transfusion Medicine National Maternity Hospital"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.","family":"Fitzgerald","sequence":"additional","affiliation":[{"name":"Red Cell Immunohaematology Laboratory Irish Blood Transfusion Service"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2014,9,17]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2008-11-146860"},{"key":"e_1_2_7_3_1","unstructured":"ANZSBT(2007)Guidelines for blood grouping and antibody screening in the antenatal and perinatal setting[WWW document]. 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