{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,11]],"date-time":"2026-10-11T21:53:34Z","timestamp":1791755614897,"version":"4.3.4"},"reference-count":35,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2014,11,13]],"date-time":"2014-11-13T00:00:00Z","timestamp":1415836800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001809","name":"Natural Science Foundation of China","doi-asserted-by":"crossref","award":["81300232"],"award-info":[{"award-number":["81300232"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Transfusion Medicine"],"published-print":{"date-parts":[[2014,12]]},"abstract":"<jats:title><jats:styled-content style=\"fixed-case\">SUMMARY<\/jats:styled-content><\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Blood transfusion and its impact upon clinical outcomes of cardiac surgery have been extensively discussed, especially in the post\u2010aprotinin era. This study compared clinical outcomes and perioperative blood utilisation among acute type A aortic dissection (<jats:styled-content style=\"fixed-case\">AAD<\/jats:styled-content>) patients with or without intraoperative platelet transfusion during total arch replacement, thus intending to investigate prognostic value of platelet transfusion during major aortic surgeries.<\/jats:p><\/jats:sec><jats:sec><jats:title>Materials and Methods<\/jats:title><jats:p>Acute <jats:styled-content style=\"fixed-case\">AAD<\/jats:styled-content> patients undergoing total arch replacement and stented elephant trunk procedure under hypothermic circulatory arrest with and without intraoperative platelet transfusion at our institute from January 2008 to December 2012 were retrospectively included. Patients were categorised into <jats:styled-content style=\"fixed-case\">PLT<\/jats:styled-content> (<jats:italic>n<\/jats:italic> = 74) and non\u2010<jats:styled-content style=\"fixed-case\">PLT<\/jats:styled-content> (<jats:italic>n<\/jats:italic> = 85) groups to compare the in\u2010hospital mortality and complications, as well as blood components utilisation.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Baseline characteristics and operational features were all comparable between two groups. In <jats:styled-content style=\"fixed-case\">PLT<\/jats:styled-content> group, in\u2010hospital survival was not improved and intraoperative utilisation of red blood cell <jats:styled-content style=\"fixed-case\">RBC<\/jats:styled-content>, fresh frozen plasma (<jats:styled-content style=\"fixed-case\">FFP<\/jats:styled-content>) and cryoprecipitate was not reduced. Postoperative <jats:styled-content style=\"fixed-case\">RBC<\/jats:styled-content> transfusion [2\u00b70(0\u20134\u00b70) vs 0(0\u20134\u00b70) U, <jats:italic>p<\/jats:italic> = 0\u00b7026; 64\u00b79 vs 43\u00b75%, <jats:italic>p<\/jats:italic> = 0\u00b7007] was significantly increased in <jats:styled-content style=\"fixed-case\">PLT<\/jats:styled-content> group, parallel with the prolonged postoperative hospitalisation time [(24\u00b70 \u00b1 12\u00b77) vs (20\u00b78 \u00b1 10\u00b79) days, <jats:italic>p<\/jats:italic> = 0\u00b7093] and elevated incidence of sternal wound infections (16\u00b72 vs 5\u00b79%, <jats:italic>p<\/jats:italic> = 0\u00b7035). Intraoperative platelet transfusion [odds ratio (<jats:styled-content style=\"fixed-case\">OR<\/jats:styled-content>): 3\u00b710, 95% confidence interval (<jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content>): 1\u00b704\u20139\u00b725, <jats:italic>p<\/jats:italic> = 0\u00b7043] was identified as independent risk factor of postoperative sternal wound infections by multivariate logistic regression analysis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Intraoperative platelet transfusion did not improve in\u2010hospital prognosis among <jats:styled-content style=\"fixed-case\">AAD<\/jats:styled-content> patients after total arch replacement. The incidence of postoperative sternal wound infections increased among those who received intraoperative platelet transfusion.<\/jats:p><\/jats:sec>","DOI":"10.1111\/tme.12162","type":"journal-article","created":{"date-parts":[[2014,11,14]],"date-time":"2014-11-14T02:59:34Z","timestamp":1415933974000},"page":"400-405","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Intraoperative platelet transfusion is associated with increased postoperative sternal wound infections among type A aortic dissection patients after total arch replacement"],"prefix":"10.1111","volume":"24","author":[{"given":"B.","family":"Wu","sequence":"first","affiliation":[{"name":"Department of Transfusion Fudan University  Shanghai China"},{"name":"Department of Hematology Fudan University  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Y.","family":"Wang","sequence":"additional","affiliation":[{"name":"Shanghai 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