{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T17:31:29Z","timestamp":1775064689087,"version":"3.50.1"},"reference-count":29,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2015,5,29]],"date-time":"2015-05-29T00:00:00Z","timestamp":1432857600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"the National Natural Science Foundation of the People\u2019s Republic of China","award":["30972815"],"award-info":[{"award-number":["30972815"]}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Transfusion Medicine"],"published-print":{"date-parts":[[2015,6]]},"abstract":"SUMMARY<\/jats:title>Objectives<\/jats:title>To analyse anti\u2010D alloimmunisation in pregnant women with D\u2010elute (DEL<\/jats:styled-content>) phenotype in China, for developing a predictive model to evaluate whether a person with the DEL<\/jats:styled-content> phenotype can receive RhD<\/jats:styled-content>\u2010positive blood.<\/jats:p><\/jats:sec>Background<\/jats:title>Alloanti\u2010D acquired by pregnancy or transfusion is one of the major causes of both haemolytic disease among newborns and haemolytic transfusion reactions. To date, there is little data available about the antigenic properties and immunogenicity of extremely weak D variants known as DEL<\/jats:styled-content>.<\/jats:p><\/jats:sec>Methods<\/jats:title>RHD<\/jats:styled-content><\/jats:italic> genotyping and D epitope mapping were performed using gene sequencing and comprehensive immunohaematological methods, respectively. DEL<\/jats:styled-content> pregnant women carrying an RhD<\/jats:styled-content>\u2010positive fetus were tested for the presence of alloanti\u2010D.<\/jats:p><\/jats:sec>Results<\/jats:title>A total of 130 of 142 (91\u00b75%) pregnant women with a DEL<\/jats:styled-content> phenotype were confirmed to carry the RHD<\/jats:styled-content> (K409K<\/jats:styled-content>)<\/jats:italic> allele. Among 12 DEL<\/jats:styled-content> women who appeared to have RHD\u2010CE<\/jats:styled-content>\u2010D<\/jats:italic> hybrid alleles, there were 1 RHD\u2010CE<\/jats:styled-content> (4\u20137)\u2010D<\/jats:italic>, 7 RHD\u2010CE<\/jats:styled-content>(4\u20139)\u2010D<\/jats:italic>, and 4 RHD\u2010CE<\/jats:styled-content> (2\u20135)\u2010D<\/jats:italic> alleles. Alloanti\u2010D antibodies were detected in 6 of 142 DEL<\/jats:styled-content> women, and all the six women had the partial DEL<\/jats:styled-content> phenotype.<\/jats:p><\/jats:sec>Conclusion<\/jats:title>The data indicate that partial DEL<\/jats:styled-content> women appear at risk of alloimmunization to the D antigen. RhD<\/jats:styled-content> immune globulin prophylaxis is necessary for partial DEL<\/jats:styled-content> women. Partial DEL<\/jats:styled-content> patients should receive only RhD<\/jats:styled-content>\u2010negative RBCs<\/jats:styled-content>, whereas DEL<\/jats:styled-content> patients with complete expression of antigen can safely receive RhD<\/jats:styled-content>\u2010positive RBCs<\/jats:styled-content>.<\/jats:p><\/jats:sec>","DOI":"10.1111\/tme.12211","type":"journal-article","created":{"date-parts":[[2015,5,29]],"date-time":"2015-05-29T17:05:19Z","timestamp":1432919119000},"page":"163-169","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":30,"title":["Anti\u2010D alloimmunisation in pregnant women with DEL<\/scp> phenotype in China"],"prefix":"10.1111","volume":"25","author":[{"given":"M.","family":"Wang","sequence":"first","affiliation":[{"name":"The Department of Blood Transfusion Affiliated Provincial Hospital of Anhui Medical University Hefei Anhui China"},{"name":"The Department of Laboratory Medicine Affiliated Provincial Hospital of Anhui Medical University Hefei Anhui China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"B. L.","family":"Wang","sequence":"additional","affiliation":[{"name":"The Department of Laboratory Medicine Affiliated Provincial Hospital of Anhui Medical University Hefei Anhui China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"W.","family":"Xu","sequence":"additional","affiliation":[{"name":"The Department of Blood Transfusion The First Affiliated Hospital of Anhui Medical University Hefei Anhui China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"D. D.","family":"Fan","sequence":"additional","affiliation":[{"name":"The Department of Epidemiology & Biostatistics, School of Public Health Anhui Medical University Hefei Anhui China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M. L.","family":"Peng","sequence":"additional","affiliation":[{"name":"The Department of Epidemiology & Biostatistics, School of Public Health Anhui Medical University Hefei Anhui China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J.","family":"Pan","sequence":"additional","affiliation":[{"name":"The Department of Blood Transfusion Affiliated Provincial Hospital of Anhui Medical University Hefei Anhui China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"P.","family":"Yao","sequence":"additional","affiliation":[{"name":"The Department of Laboratory Medicine Affiliated Provincial Hospital of Anhui Medical University Hefei Anhui China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"G. M.","family":"Jiang","sequence":"additional","affiliation":[{"name":"The Department of Blood Transfusion Affiliated Provincial Hospital of Anhui Medical University Hefei Anhui China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"X. 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