{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,2,21]],"date-time":"2025-02-21T08:22:27Z","timestamp":1740126147999,"version":"3.37.3"},"reference-count":11,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2015,11,23]],"date-time":"2015-11-23T00:00:00Z","timestamp":1448236800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Transfusion Medicine"],"published-print":{"date-parts":[[2015,12]]},"abstract":"<jats:title>SUMMARY<\/jats:title><jats:sec><jats:title>Objectives<\/jats:title><jats:p>To determine the safety of a 1\u2010week acceptance criteria of sample receipt in laboratory to transfusion commencement in transfusion dependent thalassaemia with respect to alloimmunisation. To determine the safety of electronic issue of blood components in such a setting.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Retrospective audit of alloimmunisation (1999\u20132012) and blood exposure in registered thalassaemia patients at a central London thalassaemia centre where the acceptance criteria for the group and save sample from arrival in the laboratory to the time of issue of blood for transfusion for someone who has been transfused in the last 28 days was 1 week, and there was electronic issue protocol for patients who have always had a negative antibody screen (other than temporary positivity in pregnant women receiving prophylactic anti\u2010D or anti Le\u2010a, Anti Le\u2010b and Anti <jats:styled-content style=\"fixed-case\">P1<\/jats:styled-content> that are no longer detectable).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>There were 133 patients with thalassemia variants regularly attending <jats:styled-content style=\"fixed-case\">UCLH<\/jats:styled-content> for review. A total of 105 patients had transfusion dependent thalassaemia (<jats:styled-content style=\"fixed-case\">TDT<\/jats:styled-content>) (7 E\u2010beta thalassaemia, 98 beta thalassaemia major). Ten of the 84 patients who received their transfusions at <jats:styled-content style=\"fixed-case\">UCLH<\/jats:styled-content> were alloimmunised. Seven of them had been alloimmunised prior to arrival at <jats:styled-content style=\"fixed-case\">UCLH<\/jats:styled-content>. Only two patients developed antibodies at <jats:styled-content style=\"fixed-case\">UCLH<\/jats:styled-content> during this period.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>The prevalence of alloantibody formation of 2% in <jats:styled-content style=\"fixed-case\">UCLH<\/jats:styled-content> transfused patients, with presumptive incidence of 0\u00b701 alloantibodies per 100 units or 0\u00b7001 immunisations per person per year compares favourably with other reported series and suggests that 1 week interval with appropriate electronic issue is acceptable practice.<\/jats:p><\/jats:sec>","DOI":"10.1111\/tme.12253","type":"journal-article","created":{"date-parts":[[2015,11,23]],"date-time":"2015-11-23T08:19:55Z","timestamp":1448266795000},"page":"414-417","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Sample acceptance time criteria, electronic issue and alloimmunisation in thalassaemia"],"prefix":"10.1111","volume":"25","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7099-8449","authenticated-orcid":false,"given":"S.","family":"Trompeter","sequence":"first","affiliation":[{"name":"Department of Haematology University College London NHS Foundation Trust  London UK"},{"name":"Patient Services NHS Blood and Transplant  London UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"L.","family":"Baxter","sequence":"additional","affiliation":[{"name":"Department of Haematology University College London NHS Foundation Trust  London UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.","family":"McBrearty","sequence":"additional","affiliation":[{"name":"Department of Haematology University College London NHS Foundation Trust  London UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"E.","family":"Zatkya","sequence":"additional","affiliation":[{"name":"Department of Haematology University College London NHS Foundation Trust  London UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J.","family":"Porter","sequence":"additional","affiliation":[{"name":"Department of Haematology University College London NHS Foundation Trust  London UK"},{"name":"University College London  London UK"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2015,11,23]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.3109\/08880018.2011.568595"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-3148.1996.tb00079.x"},{"key":"e_1_2_6_4_1","first-page":"35","article-title":"Guidelines for pre\u2010transfusion compatability procedures in blood transfusion laboratories","volume":"23","author":"BCSH","year":"2012","journal-title":"Transfusion Medicine"},{"key":"e_1_2_6_5_1","unstructured":"CappelliniM.D. CohenA. PorterJ. TaherJ. &ViprakasitV. (2014)Guidelines for the Management of Transfusion Dependent Thalassaemia 3rd Edition. Thalassaemia International Federation http:\/\/www.thalassaemia.org.cy\/wp-content\/uploads\/eBook-publications\/guidelines-for-the-management-of-transfusion-dependent-thalassaemia\/#\/0"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1537-2995.2012.03570.x"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1423-0410.1987.tb02999.x"},{"volume-title":"Guidelines for the Blood Transfusion Services in the UK","year":"2007","author":"NHSBT, N.B.S.","key":"e_1_2_6_8_1"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1537-2995.2006.00708.x"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V96.10.3369"},{"key":"e_1_2_6_11_1","unstructured":"UK Thalassaemia Society(2008)Standards for the Clinical Care of Children and Adults with Thalassaemia in the UK http:\/\/haemoglobin.org.uk\/pdf\/guidelines\/ukts-standards-2008.pdf"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1423-0410.1990.tb02055.x"}],"container-title":["Transfusion Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Ftme.12253","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/tme.12253","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,1]],"date-time":"2023-10-01T16:23:27Z","timestamp":1696177407000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/tme.12253"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,11,23]]},"references-count":11,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2015,12]]}},"alternative-id":["10.1111\/tme.12253"],"URL":"https:\/\/doi.org\/10.1111\/tme.12253","archive":["Portico"],"relation":{},"ISSN":["0958-7578","1365-3148"],"issn-type":[{"type":"print","value":"0958-7578"},{"type":"electronic","value":"1365-3148"}],"subject":[],"published":{"date-parts":[[2015,11,23]]},"assertion":[{"value":"2015-03-09","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2015-09-17","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2015-11-23","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}