{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,5]],"date-time":"2026-08-05T01:26:30Z","timestamp":1785893190834,"version":"3.56.0"},"reference-count":5,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2016,2,23]],"date-time":"2016-02-23T00:00:00Z","timestamp":1456185600000},"content-version":"vor","delay-in-days":84,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Transfusion Medicine"],"published-print":{"date-parts":[[2015,12]]},"abstract":"<jats:title>SUMMARY<\/jats:title><jats:sec><jats:title>Objectives<\/jats:title><jats:p>To establish whether passive transfer of cytomegalovirus (CMV) IgG via transfusion results in ambiguous serostatus in patients undergoing allogeneic stem cell transplant (SCT).<\/jats:p><\/jats:sec><jats:sec><jats:title>Background<\/jats:title><jats:p>CMV infection causes significant morbidity following allogeneic SCT. Leucocyte\u2010reduced blood products from CMV\u2010seropositive donors carry minimal risk of CMV transmission, however, may result in passive transfer of CMV IgG, leading to unintentionally CMV\u2010mismatched recipient\/donors with significant consequences.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We undertook a retrospective single\u2010centre analysis of CMV IgG results in patients transfused with CMV\u2010unselected (CMV\u2010U) leucocyte\u2010reduced components subsequently undergoing SCT.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Of patients with &gt;1CMV IgG measured, 8\/29 (27\u00b76%) had discordant results; all were transfused between negative and subsequent positive results and were thought to have passively acquired CMV IgG. One likely CMV na\u00efve patient was recorded as CMV seropositive and underwent transplant with a seropositive donor, developing CMV infection which required treatment.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Passive transfer of CMV IgG is an unanticipated consequence of transfusion of CMV\u2010U products and has the potential to cause morbidity. Inaccurate recording of serostatus pre\u2010transplant has wider implications for data reporting on transplant outcomes. When transfusing CMV\u2010U components pre\u2010transfusion CMV IgG samples must be taken and transfusion history must be considered when interpreting results.<\/jats:p><\/jats:sec>","DOI":"10.1111\/tme.12264","type":"journal-article","created":{"date-parts":[[2016,2,26]],"date-time":"2016-02-26T02:21:46Z","timestamp":1456453306000},"page":"411-413","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":16,"title":["Transfusion of CMV\u2010unselected blood components may lead to inappropriate donor selection for patients subsequently undergoing allogeneic stem cell transplant"],"prefix":"10.1111","volume":"25","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2263-3223","authenticated-orcid":false,"given":"S.","family":"Morton","sequence":"first","affiliation":[{"name":"NHS Blood &amp; Transplant  Birmingham UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R.","family":"Danby","sequence":"additional","affiliation":[{"name":"Department of Haematology Oxford University Hospitals  Oxford UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"V.","family":"Rocha","sequence":"additional","affiliation":[{"name":"Department of Haematology Oxford University Hospitals  Oxford UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"Peniket","sequence":"additional","affiliation":[{"name":"Department of Haematology Oxford University Hospitals  Oxford UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M. F.","family":"Murphy","sequence":"additional","affiliation":[{"name":"NHS Blood &amp; Transplant John Radcliffe Hospital  Oxford UK"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2016,2,23]]},"reference":[{"key":"e_1_2_8_2_1","unstructured":"Advisory committee on the safety of blood tissues and organs. (2012)Report of the Cytomegalovirus Steering Group. URLhttp:\/\/www.gov.uk\/government\/uploads\/system\/uploads\/attachment_data\/file\/215126\/dh_132966.pdf(Accessed 9\/2\/15)."},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2003-10-3616"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2013-05-499830"},{"key":"e_1_2_8_5_1","doi-asserted-by":"crossref","unstructured":"Shaw B. Mayor N. Richard S. Bultitude W.P. Kirkland K. Perry J. Wilson M. Clark A. Mackinnon S. Marks D. Pagliuca A. Potter M. Russell N. Thomson K. Madrigal J.A.&Marsh S.G.(2015) 1207: Patient\/Donor CMV Matching is a Critical Determinant of Survival in Unrelated Donor Haematopoietic Stem Cell Transplantation. Annual meeting of the American Society of Hematology San Francisco California.","DOI":"10.1182\/blood.V124.21.1207.1207"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1537-2995.2011.03203.x"}],"container-title":["Transfusion Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Ftme.12264","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/tme.12264","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,1]],"date-time":"2023-10-01T16:23:30Z","timestamp":1696177410000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/tme.12264"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,12]]},"references-count":5,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2015,12]]}},"alternative-id":["10.1111\/tme.12264"],"URL":"https:\/\/doi.org\/10.1111\/tme.12264","archive":["Portico"],"relation":{},"ISSN":["0958-7578","1365-3148"],"issn-type":[{"value":"0958-7578","type":"print"},{"value":"1365-3148","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,12]]},"assertion":[{"value":"2015-06-13","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2015-11-15","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2016-02-23","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}