{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T17:30:56Z","timestamp":1775064656070,"version":"3.50.1"},"reference-count":24,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2016,1,11]],"date-time":"2016-01-11T00:00:00Z","timestamp":1452470400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Transfusion Medicine"],"published-print":{"date-parts":[[2016,2]]},"abstract":"<jats:title>SUMMARY<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>One of the biggest concerns in transfusion medicine is to avoid red blood cell alloimmunization. We evaluated the rate of alloimmunization in two groups of chronically transfused patients (A \u2013 not phenotyped and B \u2013 phenotyped for Rh\/K antigens before the first transfusion) with primary haematological disorders and its distribution among the main haematological diseases, in order to adopt an efficient transfusional strategy.<\/jats:p><\/jats:sec><jats:sec><jats:title>Study design and methods<\/jats:title><jats:p>As methodology, we used the <jats:styled-content style=\"fixed-case\">SIBAS<\/jats:styled-content> and <jats:styled-content style=\"fixed-case\">SAM<\/jats:styled-content> databases for the retrospective study of all patients with primary haematological disorder between January 2011 and April 2013.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A statistical difference in the rate of alloimmunization comparing groups A and B was found (<jats:italic>P<\/jats:italic> &lt;0\u00b70001). We also observed that alloimmunization was not homogeneously distributed in all primary haematological diseases.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>The Rh\/K phenotype should be performed on all patients diagnosed with bone marrow failure, plasma cell dyscrasia and myelodysplastic syndrome in order to avoid alloimmunization. In patients with acute leukaemia and lymphoma it seems not necessary to perform it. In patients with haemoglobinopathy and myeloproliferative disorders, a larger group of patients is needed to decide its efficacy.<\/jats:p><\/jats:sec>","DOI":"10.1111\/tme.12271","type":"journal-article","created":{"date-parts":[[2016,1,11]],"date-time":"2016-01-11T07:43:46Z","timestamp":1452498226000},"page":"34-38","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["Phenotyping Rh\/Kell and risk of alloimmunization in haematological patients"],"prefix":"10.1111","volume":"26","author":[{"given":"F.","family":"Ba\u00eda","sequence":"first","affiliation":[{"name":"Servi\u00e7o de Imunohemoterapia, Laborat\u00f3rio de Imuno\u2010hematologia, Transfusion Medicine Department and Blood Bank Centro Hospitalar S\u00e3o Jo\u00e3o"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"F.","family":"Correia","sequence":"additional","affiliation":[{"name":"Servi\u00e7o de Imunohemoterapia, Laborat\u00f3rio de Imuno\u2010hematologia, Transfusion Medicine Department and Blood Bank Centro Hospitalar S\u00e3o Jo\u00e3o"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"B.","family":"Alves","sequence":"additional","affiliation":[{"name":"Servi\u00e7o de Imunohemoterapia, Laborat\u00f3rio de Imuno\u2010hematologia, Transfusion Medicine Department and Blood Bank Centro Hospitalar S\u00e3o Jo\u00e3o"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"F.","family":"Martinez","sequence":"additional","affiliation":[{"name":"Servi\u00e7o de Imunohemoterapia, Laborat\u00f3rio de Imuno\u2010hematologia, Transfusion Medicine Department and Blood Bank Centro Hospitalar S\u00e3o Jo\u00e3o"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C.","family":"Koch","sequence":"additional","affiliation":[{"name":"Servi\u00e7o de Imunohemoterapia, Laborat\u00f3rio de Imuno\u2010hematologia, Transfusion Medicine Department and Blood Bank Centro Hospitalar S\u00e3o 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