{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,3]],"date-time":"2026-08-03T15:53:48Z","timestamp":1785772428327,"version":"3.56.0"},"reference-count":49,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2016,4,8]],"date-time":"2016-04-08T00:00:00Z","timestamp":1460073600000},"content-version":"vor","delay-in-days":67,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100009033","name":"NHS Blood and Transplant","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100009033","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100006662","name":"National Institute on Handicapped Research","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100006662","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Transfusion Medicine"],"published-print":{"date-parts":[[2016,2]]},"abstract":"SUMMARY<\/jats:title>Vasovagal reactions (VVRs<\/jats:styled-content>) in blood donors have significant implications for the welfare of donors, donor retention and the management of donor sessions. We present a systematic review of interventions designed to prevent or reduce VVRs<\/jats:styled-content> in blood donors. Electronic databases were searched for eligible randomised trials to March 2015. Data on study design and outcomes were extracted and pooled using random effects meta\u2010analyses. Sixteen trials met the inclusion criteria: five trials (12 042 participants) of pre\u2010donation water, eight trials (3500 participants) of applied muscle tension (AMT<\/jats:styled-content>) and one trial each of AMT<\/jats:styled-content> combined with water, caffeine, audio\u2010visual distraction and\/or social support. In donors receiving pre\u2010donation water, the relative risk (RR<\/jats:styled-content>) compared with controls for VVRs<\/jats:styled-content> was 0\u00b779 [95% confidence interval (CI<\/jats:styled-content>) 0\u00b770\u20130\u00b789, P<\/jats:italic> < 0\u00b70001] and the mean difference (MD<\/jats:styled-content>) in severity of VVRs<\/jats:styled-content> measured with the Blood Donation Reactions Inventory (BDRI<\/jats:styled-content>) score was \u22120\u00b732 (95% CI<\/jats:styled-content> \u22120\u00b751 to \u22120\u00b712, P<\/jats:italic> < 0\u00b70001). Excluding trials with a high risk of selection bias, the RR<\/jats:styled-content> for VVRs<\/jats:styled-content> was 0\u00b770 (95% CI<\/jats:styled-content> 0\u00b745\u20131\u00b711, P<\/jats:italic> = 0\u00b713). In donors who received AMT<\/jats:styled-content>, there was no difference in the risk of chair recline in response to donor distress from controls (RR<\/jats:styled-content> 0\u00b776, 95% CI<\/jats:styled-content> 0\u00b753\u20131\u00b710, P<\/jats:italic> = 0\u00b715), although the MD<\/jats:styled-content> in BDRI<\/jats:styled-content> score was \u22120\u00b707 (95% CI<\/jats:styled-content> \u22120\u00b711 to \u22120\u00b703, P<\/jats:italic> = 0\u00b70005). There was insufficient data to perform meta\u2010analysis for other interventions. Current evidence on interventions to prevent or reduce VVRs<\/jats:styled-content> in blood donors is indeed limited and does not provide strong support for the administration of pre\u2010donation water or AMT<\/jats:styled-content> during donation. Further large trials are required to reliably evaluate the effect of these and other interventions in the prevention of VVRs<\/jats:styled-content>.<\/jats:p>","DOI":"10.1111\/tme.12275","type":"journal-article","created":{"date-parts":[[2016,4,11]],"date-time":"2016-04-11T01:44:56Z","timestamp":1460339096000},"page":"15-33","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":42,"title":["Interventions to reduce vasovagal reactions in blood donors: a systematic review and meta\u2010analysis"],"prefix":"10.1111","volume":"26","author":[{"given":"S. A.","family":"Fisher","sequence":"first","affiliation":[{"name":"Systematic Review Initiative NHS Blood and Transplant Oxford UK"},{"name":"Nuffield Division of Clinical Laboratory Sciences, Radcliffe Department of Medicine University of Oxford Oxford UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D.","family":"Allen","sequence":"additional","affiliation":[{"name":"Blood Research Group NHS Blood and Transplant Oxford UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C.","family":"Dor\u00e9e","sequence":"additional","affiliation":[{"name":"Systematic Review Initiative NHS Blood and Transplant Oxford UK"},{"name":"Nuffield Division of Clinical Laboratory Sciences, Radcliffe Department of Medicine University of Oxford Oxford UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.","family":"Naylor","sequence":"additional","affiliation":[{"name":"Blood Supply NHS Blood and Transplant Leeds UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"E.","family":"Di Angelantonio","sequence":"additional","affiliation":[{"name":"Department of Public Health and Primary Care University of Cambridge Cambridge UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D. J.","family":"Roberts","sequence":"additional","affiliation":[{"name":"Systematic Review Initiative NHS Blood and Transplant Oxford UK"},{"name":"Nuffield Division of Clinical Laboratory Sciences, Radcliffe Department of Medicine University of Oxford Oxford UK"},{"name":"Blood Research Group NHS Blood and Transplant Oxford UK"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2016,4,8]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.blre.2011.09.003"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1537-2995.2012.03631.x"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1097\/00006842-200105000-00014"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1423-0410.2011.01494.x"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1537-2995.2006.00835.x"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1037\/0278-6133.25.3.433"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1537-2995.2003.00488.x"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1023\/A:1021795022380"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1537-2995.2007.01449.x"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12160-009-9114-7"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1537-2995.2008.02067.x"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1423-0410.2009.01273.x"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1111\/vox.12055"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1537-2995.2012.03810.x"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1097\/MOH.0b013e328358b15c"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1537-2995.2011.03143.x"},{"key":"e_1_2_7_18_1","unstructured":"Fisher S.A. Allen D. Doree C. Roberts D.R.(2013) Systematic review of interventions to reduce fainting or syncope in blood donors.PROSPERO:International prospective register of systematic reviews: CRD42013004954 [WWW document]. URLhttp:\/\/www.crd.york.ac.uk\/PROSPERO\/display_record.asp?ID=CRD42013004954(Accessed 1st October 2015)"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.transci.2003.08.014"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.transci.2005.02.005"},{"key":"e_1_2_7_21_1","first-page":"80A","article-title":"Pre\u2010donation hydration and applied muscle tension combine to reduce vasovagal reactions and enhance donor return","volume":"48","author":"France C.","year":"2008","journal-title":"Transfusion"},{"key":"e_1_2_7_22_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1537-2995.2009.02574.x"},{"key":"e_1_2_7_23_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1537-2995.2004.03426.x"},{"key":"e_1_2_7_24_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1537-2995.2008.02057.x"},{"key":"e_1_2_7_25_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.d5928"},{"key":"e_1_2_7_26_1","doi-asserted-by":"publisher","DOI":"10.1037\/a0022998"},{"key":"e_1_2_7_27_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12160-011-9315-8"},{"key":"e_1_2_7_28_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1537-2995.2011.03075.x"},{"key":"e_1_2_7_29_1","doi-asserted-by":"publisher","DOI":"10.1207\/S15327558IJBM0701_5"},{"key":"e_1_2_7_30_1","unstructured":"Lee W.Y.S.&Khaw K.S.(2014) Prevention of vasovagal reactions in blood donors: Comparison of efficacy and haemodynamic effects of oral prehydration fluids.Chinese Clinical Trial Registry pp. ChiCTR\u2010IPR\u201014005447."},{"key":"e_1_2_7_31_1","doi-asserted-by":"publisher","DOI":"10.1016\/0022-3999(95)00639-7"},{"key":"e_1_2_7_32_1","first-page":"111A","article-title":"A randomized study to evaluate hydration by isotonic solution and\/or muscle tension as a means to prevent fainting after whole blood donation (evasion): A preliminary report","volume":"54","author":"Morand C.","year":"2014","journal-title":"Transfusion"},{"key":"e_1_2_7_33_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1751-2824.2009.01269.x"},{"key":"e_1_2_7_34_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1537-2995.2003.00478.x"},{"key":"e_1_2_7_35_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1537-2995.2011.03439.x"},{"key":"e_1_2_7_36_1","first-page":"87A","article-title":"The effect of a 16\u2010oz water drink on blood donor reaction rates in high\u2010school students","volume":"45","author":"Newman B.H.","year":"2005","journal-title":"Transfusion"},{"key":"e_1_2_7_37_1","first-page":"80A","article-title":"The effect of a 16\u2010oz water drink on blood donor reaction rates in high\u2010school students: two independent studies combined","volume":"46","author":"Newman B.","year":"2006","journal-title":"Transfusion"},{"key":"e_1_2_7_38_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1537-2995.2006.00905.x"},{"key":"e_1_2_7_39_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1537-2995.2007.01293.x"},{"key":"e_1_2_7_40_1","unstructured":"Review Manager (RevMan)(2014) [computer program]. Version 5.3. Copenhagen: The Nordic Cochrane Centre The Cochrane Collaboration."},{"key":"e_1_2_7_41_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1537-2995.2009.02578.x"},{"key":"e_1_2_7_42_1","doi-asserted-by":"publisher","DOI":"10.1037\/0278-6133.18.4.403"},{"key":"e_1_2_7_43_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.transci.2012.04.002"},{"key":"e_1_2_7_44_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1751-2824.2010.01363.x"},{"key":"e_1_2_7_45_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1537-2995.2011.03074.x"},{"key":"e_1_2_7_46_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.transci.2008.07.010"},{"key":"e_1_2_7_47_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1537-2995.1999.39399219291.x"},{"key":"e_1_2_7_48_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.janxdis.2010.06.021"},{"issue":"1","key":"e_1_2_7_49_1","first-page":"s28","article-title":"Risk factors for complications in donors at first and repeat whole blood donation: a cohort study with assessment of the impact on donor return","volume":"12","author":"Wiersum\u2010Osselton J.C.","year":"2014","journal-title":"Blood Transfusion"},{"key":"e_1_2_7_50_1","first-page":"46","volume-title":"Blood Donor Selection: Guidelines on Assessing Donor Suitability for Blood Donation","author":"World Health Organisation","year":"2012"}],"container-title":["Transfusion Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Ftme.12275","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Ftme.12275","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/tme.12275","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,29]],"date-time":"2023-09-29T22:18:44Z","timestamp":1696025924000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/tme.12275"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,2]]},"references-count":49,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2016,2]]}},"alternative-id":["10.1111\/tme.12275"],"URL":"https:\/\/doi.org\/10.1111\/tme.12275","archive":["Portico"],"relation":{},"ISSN":["0958-7578","1365-3148"],"issn-type":[{"value":"0958-7578","type":"print"},{"value":"1365-3148","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,2]]},"assertion":[{"value":"2015-10-22","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2015-12-24","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2016-04-08","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}