{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T01:22:51Z","timestamp":1787016171293,"version":"build-2736575974"},"reference-count":26,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2016,3,28]],"date-time":"2016-03-28T00:00:00Z","timestamp":1459123200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"King Abdul-Aziz City for Science and Technology"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Transfusion Medicine"],"published-print":{"date-parts":[[2016,6]]},"abstract":"SUMMARY<\/jats:title>\n \n Background<\/jats:title>\n \n Human platelet antigens (\n HPAs<\/jats:styled-content>\n ) are involved in the pathogenesis of several clinical conditions, such as platelet transfusion purpura (\n PTP<\/jats:styled-content>\n ), refractoriness to platelet transfusion and neonatal alloimmune thrombocytopenia (\n NAITP<\/jats:styled-content>\n ). Typing of\n HPA<\/jats:styled-content>\n (1\u20136 and 15) has not been carried on the Saudi population. This is the first study of all the seven\n HPA<\/jats:styled-content>\n systems on Arabs. The aim of this prospective study was to determine the frequency of\n HPA<\/jats:styled-content>\n (1\u20136 and 15) in Saudis.\n <\/jats:p>\n <\/jats:sec>\n \n Study design and methods<\/jats:title>\n \n A total of 100 randomly selected Saudi blood donor samples were genotyped using the polymerase chain reaction with sequence\u2010specific primers (\n PCR\u2010SSP<\/jats:styled-content>\n ).\n <\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n \n The most common\n HPA<\/jats:styled-content>\n genotypes among Saudis were\n HPA\u20101<\/jats:styled-content>\n a + b\u2212 (75%),\n HPA\u20102<\/jats:styled-content>\n a + b\u2212 (62%),\n HPA\u20103<\/jats:styled-content>\n a + b\u2212 (51\u00b75%),\n HPA\u20104<\/jats:styled-content>\n a + b\u2212 (99%),\n HPA\u20105<\/jats:styled-content>\n a + b\u2212 (76\u00b75%),\n HPA\u20106<\/jats:styled-content>\n a + b\u2212 (100%) and\n HPA\u201015<\/jats:styled-content>\n a + b + (50%). The prevalent allele among the\n HPA<\/jats:styled-content>\n systems was (a), except in the\n HPA<\/jats:styled-content>\n \u201015 system where the (b) allele was found in 52% of the subjects. Comparisons with other ethnic populations uncovered marked differences in the distribution of\n HPA<\/jats:styled-content>\n alleles.\n <\/jats:p>\n <\/jats:sec>\n \n Conclusion<\/jats:title>\n \n Studying the prevalence of\n HPA<\/jats:styled-content>\n antigens in Saudi population will help in the understanding of its role in platelet\u2010related disorders. It will also enable the blood bank to establish an\n HPA<\/jats:styled-content>\n \u2010based donor registry that will be a valuable source of compatible platelet\u2010therapeutic products to alloimmunised patients. This will also enhance the safety and efficacy of platelet transfusion. This data obtained will form an addition to the existing body of literature in transfusion research.\n <\/jats:p>\n <\/jats:sec>","DOI":"10.1111\/tme.12297","type":"journal-article","created":{"date-parts":[[2016,3,28]],"date-time":"2016-03-28T03:22:35Z","timestamp":1459135355000},"page":"220-224","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":14,"title":["Gene frequency of human platelet alloantigens\u20101 to \u20106 and \u201015 in Saudi blood donors"],"prefix":"10.1111","volume":"26","author":[{"given":"S. K.","family":"Al\u2010Ouda","sequence":"first","affiliation":[{"name":"Department of Clinical Laboratory Sciences, College of Applied Medical Sciences King Saud University Riyadh Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A. A.","family":"Al\u2010Banyan","sequence":"additional","affiliation":[{"name":"Department of Clinical Laboratory Sciences, College of Applied Medical Sciences King Saud University Riyadh Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A. G. M.","family":"Abdel Gader","sequence":"additional","affiliation":[{"name":"Department of Basic Medical Science, College of Medicine King Saud bin Abdulaziz University for Health Sciences Riyadh Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"N. M.","family":"Bayoumy","sequence":"additional","affiliation":[{"name":"Department of Physiology King Saud University Riyadh Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"F. H.","family":"Al\u2010Gahtani","sequence":"additional","affiliation":[{"name":"Transfusion Medicine Unit King Khalid University Hospital, King Saud University Riyadh Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2016,3,28]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"crossref","first-page":"168","DOI":"10.26719\/2000.6.1.168","article-title":"Genotyping human platelet alloantigens (HPA 1\u20105) in Saudis from Eastern Province, Saudi Arabia","volume":"6","author":"Al\u2010Sheikh I.","year":"2000","journal-title":"Eastern Mediterranean Health Journal"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajh.20769"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-3148.2002.00371.x"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-3148.2009.00982.x"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.thj.6200338"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1399-0039.2009.01429.x"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2370.1999.00174.x"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-3148.2007.00819.x"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-3148.2006.00687.x"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1399-0039.2004.00149.x"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2370.2003.00426.x"},{"key":"e_1_2_7_13_1","doi-asserted-by":"crossref","first-page":"1722","DOI":"10.1182\/blood.V70.6.1722.1722","article-title":"Monoclonal antibody\u2014specific immobilization of platelet antigens (MAIPA): a new tool for the identification of platelet reactive antibodies","volume":"70","author":"Kifel V.","year":"1987","journal-title":"Blood"},{"key":"e_1_2_7_14_1","first-page":"28","article-title":"Fetomaternal alloimmune thrombocytopenia\u2010possibilities of diagnosis and exchange transfusion","volume":"64","author":"Korinkova P.","year":"1999","journal-title":"Cesk\u00e1 Gynekologie"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.3109\/9780203997352.204"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.0958-7578.2005.00561.x"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00277-002-0451-x"},{"key":"e_1_2_7_18_1","unstructured":"Mazzucco L. 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