{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,20]],"date-time":"2026-08-20T14:50:46Z","timestamp":1787237446617,"version":"build-2736575974"},"reference-count":34,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2016,5,20]],"date-time":"2016-05-20T00:00:00Z","timestamp":1463702400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Transfusion Medicine"],"published-print":{"date-parts":[[2016,6]]},"abstract":"<jats:title>SUMMARY<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>\n                      Comparison of the alloimmunisation rates of patients with sickle cell disease in the\n                      <jats:styled-content style=\"fixed-case\">Unites States<\/jats:styled-content>\n                      versus other countries.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>\n                      Sickle cell disease (\n                      <jats:styled-content style=\"fixed-case\">SCD<\/jats:styled-content>\n                      ) patients treated with chronic transfusion therapy are at a high risk of red blood cell (\n                      <jats:styled-content style=\"fixed-case\">RBC<\/jats:styled-content>\n                      ) alloimmunisation.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Materials and Methods<\/jats:title>\n                    <jats:p>\n                      We reviewed published literature describing alloimmunisation rates of\n                      <jats:styled-content style=\"fixed-case\">SCD<\/jats:styled-content>\n                      patients. Average alloimmunisation rates and number of alloantibodies per transfused patient in the\n                      <jats:styled-content style=\"fixed-case\">United States<\/jats:styled-content>\n                      and other countries were evaluated.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Twenty\u2010four studies on alloimmunisation of\n                      <jats:styled-content style=\"fixed-case\">SCD<\/jats:styled-content>\n                      patients were found, 15 studies with 3,708 patients in the\n                      <jats:styled-content style=\"fixed-case\">US<\/jats:styled-content>\n                      and 9 studies with 2203 patients from other regions, including South America, the Caribbean, Middle East, Africa and Europe. The\n                      <jats:styled-content style=\"fixed-case\">United States<\/jats:styled-content>\n                      has a higher alloimmunisation rate (22\u00b733\u2009\u00b1\u20090\u00b713% versus 16\u00b725\u2009\u00b1\u20090\u00b735%, p\u2009&lt;\u20090\u00b70001) and a higher number of alloantibodies per transfused patient (0\u00b745\u2009\u00b1\u20090\u00b7003 versus 0\u00b720\u2009\u00b1\u20090\u00b7005, p\u2009&lt;\u20090\u00b70001) than other countries. Brazil with a higher proportion of multi\u2010ethnic donors demonstrated a lower alloimmunisation rate compared to the\n                      <jats:styled-content style=\"fixed-case\">United States<\/jats:styled-content>\n                      (14\u00b760\u2009\u00b1\u20090\u00b740% versus 22\u00b733\u2009\u00b1\u20090\u00b713%, p\u2009&lt;\u20090\u00b70001) and fewer alloantibodies per transfused patient (0\u00b720\u2009\u00b1\u20090\u00b702 versus 0\u00b745\u2009\u00b1\u20090\u00b7003, p\u2009&lt;\u20090\u00b70001) than the\n                      <jats:styled-content style=\"fixed-case\">United States<\/jats:styled-content>\n                      .\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>\n                      <jats:styled-content style=\"fixed-case\">SCD<\/jats:styled-content>\n                      patients in the\n                      <jats:styled-content style=\"fixed-case\">United States<\/jats:styled-content>\n                      had a higher alloimmunisation rate, which could be reduced by a more ethnically diverse donor pool and a more conservative transfusion strategy in non\u2010critical conditions.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/tme.12314","type":"journal-article","created":{"date-parts":[[2016,5,21]],"date-time":"2016-05-21T17:57:55Z","timestamp":1463853475000},"page":"225-230","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":22,"title":["Alloimmunisation rates of sickle cell disease patients in the United States differ from those in other geographical regions"],"prefix":"10.1111","volume":"26","author":[{"given":"Y.","family":"Zheng","sequence":"first","affiliation":[{"name":"Department of Pathology\/ Division of Transfusion Medicine University Hospitals Case Medical Center, Case Western Reserve University School of Medicine  Cleveland Ohio USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R. W.","family":"Maitta","sequence":"additional","affiliation":[{"name":"Department of Pathology\/ Division of Transfusion Medicine University Hospitals Case Medical Center, Case Western Reserve University School of Medicine  Cleveland Ohio USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2016,5,20]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1537-2995.1987.27187121485.x"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1537-2995.2009.02185.x"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1537-2995.2002.00007.x"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.26719\/2007.13.5.1181"},{"key":"e_1_2_7_6_1","unstructured":"Brazilian Institute of Geography and Statistics(2008)Brazil National Household Sample Survey Rio de Janeiro Brazil. URLhttp:\/\/www.ibge.gov.br\/english\/estatistica\/populacao\/caracteristicas_raciais\/default_raciais.shtm(Accessed 1\/8\/15)."},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1537-2995.2009.02529.x"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1537-2995.2002.00126.x"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/bjh.12061"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2013-03-490623"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1537-2995.1981.21481276005.x"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.5581\/1516-8484.20130012"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1001\/archinte.1988.00380110115024"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2141.1986.tb05546.x"},{"key":"e_1_2_7_15_1","first-page":"136","article-title":"Alloimmunization and clinical profile of sickle cell disease patients from Salvador\u2010Brazil","volume":"20","author":"Dias Zanette A.M.","year":"2010","journal-title":"Ethnicity & Disease"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1002\/pbc.22647"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1537-2995.2010.03045.x"},{"key":"e_1_2_7_18_1","first-page":"314","article-title":"Variability in rates of alloimmunization in different groups of children with sickle cell disease: effect of ethnic background","volume":"11","author":"Luban N.L.","year":"1989","journal-title":"The American Journal of Pediatric Hematology\/Oncology"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1111\/trf.12382"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1096-8652(199607)52:3<197::AID-AJH11>3.0.CO;2-D"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.1590\/S0100-879X2005000500004"},{"key":"e_1_2_7_22_1","doi-asserted-by":"publisher","DOI":"10.1111\/trf.12342"},{"key":"e_1_2_7_23_1","unstructured":"The U.S. Department of Health and Human Services(2011)National Blood Collection and Utilization Survey Report Washington DC. URLhttp:\/\/www.hhs.gov\/ash\/bloodsafety\/nbcus\/(Accessed 31\/8\/15)."},{"key":"e_1_2_7_24_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1537-2995.2009.02435.x"},{"key":"e_1_2_7_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1246-7820(05)80054-0"},{"key":"e_1_2_7_26_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2141.2001.02819.x"},{"key":"e_1_2_7_27_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajh.2830050204"},{"key":"e_1_2_7_28_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1749-6632.1989.tb24219.x"},{"key":"e_1_2_7_29_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1399-0039.1987.tb01615.x"},{"key":"e_1_2_7_30_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V76.7.1431.1431"},{"key":"e_1_2_7_31_1","doi-asserted-by":"publisher","DOI":"10.1196\/annals.1345.072"},{"key":"e_1_2_7_32_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1537-2995.1986.26386209381.x"},{"key":"e_1_2_7_33_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199006073222301"},{"key":"e_1_2_7_34_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2014.10517"},{"key":"e_1_2_7_35_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2011-11-327361"}],"container-title":["Transfusion Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Ftme.12314","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/tme.12314","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,1]],"date-time":"2023-10-01T08:17:30Z","timestamp":1696148250000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/tme.12314"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,5,20]]},"references-count":34,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2016,6]]}},"alternative-id":["10.1111\/tme.12314"],"URL":"https:\/\/doi.org\/10.1111\/tme.12314","archive":["Portico"],"relation":{},"ISSN":["0958-7578","1365-3148"],"issn-type":[{"value":"0958-7578","type":"print"},{"value":"1365-3148","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,5,20]]},"assertion":[{"value":"2015-09-25","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2016-04-26","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2016-05-20","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}