{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,11]],"date-time":"2025-11-11T15:43:23Z","timestamp":1762875803811},"reference-count":60,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2016,8,16]],"date-time":"2016-08-16T00:00:00Z","timestamp":1471305600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100006506","name":"Minist\u00e9rio da Sa\u00fade","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100006506","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004916","name":"Funda\u00e7\u00e3o de Amparo \u00e0 Pesquisa do Estado do Amazonas","doi-asserted-by":"publisher","award":["PECTI\/AM\u2010SA\u00daDE N.001\/2012"],"award-info":[{"award-number":["PECTI\/AM\u2010SA\u00daDE N.001\/2012"]}],"id":[{"id":"10.13039\/501100004916","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Transfusion Medicine"],"published-print":{"date-parts":[[2016,12]]},"abstract":"<jats:title>SUMMARY<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Human platelet antigens (HPAs) are alloantigens derived from polymorphisms in platelet\u2010surface glycoproteins. The occurrence of alloantibodies against HPAs can lead to platelet destruction and subsequent thrombocytopenia. Brazilians have a high rate of racial admixture, and the knowledge of HPA polymorphisms in particular donors from north Brazil, who have a large Amerindian influence, is a relevant strategy to prevent alloimmunisation.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objective<\/jats:title><jats:p>Our aim was investigate the HPA allele's frequencies in the Amazonas blood donors.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We performed HPA genotyping among 200 Amazonas blood donors by microarray for 11 HPA biallelic systems, including six of the most clinically significant systems (HPA\u20101 to \u20105 and \u201015) and five others (HPA\u20106 to \u20109 and \u201011) that have been also associated with alloimmunisation, amounting to 22 HPA alleles.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The obtained allele frequencies were compared with data of 38 populations worldwide to determine the hierarchical relationship and estimated the probability of mismatch platelets. The allele frequencies were 0\u00b7862 for HPA\u20101<jats:italic>a<\/jats:italic>, 0\u00b7137 for HPA\u20101<jats:italic>b<\/jats:italic>, 0\u00b7852 for HPA\u20102<jats:italic>a<\/jats:italic>, 0\u00b7147 for HPA\u20102<jats:italic>b<\/jats:italic>, 0\u00b7665 for HPA\u20103<jats:italic>a<\/jats:italic>, 0\u00b7335 for HPA\u20103<jats:italic>b<\/jats:italic>, 0\u00b7995 for HPA\u20104<jats:italic>a<\/jats:italic>, 0\u00b7005 for HPA\u20104<jats:italic>b<\/jats:italic>, 0\u00b7892 for HPA\u20105<jats:italic>a<\/jats:italic>, 0\u00b7107 for HPA\u20105<jats:italic>b<\/jats:italic>, 0\u00b7997 for HPA\u20109<jats:italic>a<\/jats:italic>, 0\u00b7005 for HPA\u20109<jats:italic>b<\/jats:italic>, 0\u00b7502 for HPA\u201015<jats:italic>a<\/jats:italic> and 0\u00b7497 for HPA\u201015<jats:italic>b<\/jats:italic>. The incompatibility risks are higher for HPA\u201015 and HPA\u20103, followed by HPA\u20101, \u20102 and \u20105.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>We found differences among populations worldwide, and it is interesting to note the indigenous and European influences in this region, reinforcing the heterogeneity in the ancestry of Brazilians. The results will be helpful in providing information for platelet transfusion to avoid alloimmunisation.<\/jats:p><\/jats:sec>","DOI":"10.1111\/tme.12338","type":"journal-article","created":{"date-parts":[[2016,8,16]],"date-time":"2016-08-16T06:02:47Z","timestamp":1471327367000},"page":"448-456","update-policy":"http:\/\/dx.doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["The human platelet alloantigen profile in blood donors from Amazonas, Brazil"],"prefix":"10.1111","volume":"26","author":[{"given":"C. N.","family":"Portela","sequence":"first","affiliation":[{"name":"P\u00f3s\u2010Gradua\u00e7\u00e3o em Ci\u00eancias Aplicadas \u00e0 Hematologia Universidade do Estado do Amazonas e Funda\u00e7\u00e3o de Hematologia e Hemoterapia do Amazonas  Manaus Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A.","family":"Schriefer","sequence":"additional","affiliation":[{"name":"Servi\u00e7o de Imunologia, Hospital Universit\u00e1rio Professor Edgard Santos, Universidade Federal da Bahia; Departamento de Ci\u00eancias da Biointera\u00e7\u00e3o, Instituto de Ci\u00eancias da Sa\u00fade Instituto de Ci\u00eancia e Tecnologia em Doen\u00e7as Tropicais  Salvador Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S. R. L.","family":"Albuquerque","sequence":"additional","affiliation":[{"name":"P\u00f3s\u2010Gradua\u00e7\u00e3o em Ci\u00eancias Aplicadas \u00e0 Hematologia Universidade do Estado do Amazonas e Funda\u00e7\u00e3o de Hematologia e Hemoterapia do Amazonas  Manaus Brazil"},{"name":"Laborat\u00f3rio de Imunohematologia Molecular Funda\u00e7\u00e3o de Hematologia e Hemoterapia do Amazonas  Manaus Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R. T.","family":"Perdomo","sequence":"additional","affiliation":[{"name":"Centro de Ci\u00eancias Biol\u00f3gicas e da Sa\u00fade Universidade Federal do Mato Grosso do Sul  Campo Grande Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A. F. 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