{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,10]],"date-time":"2026-03-10T15:48:58Z","timestamp":1773157738501,"version":"3.50.1"},"reference-count":28,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2016,10,10]],"date-time":"2016-10-10T00:00:00Z","timestamp":1476057600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Transfusion Medicine"],"published-print":{"date-parts":[[2017,2]]},"abstract":"<jats:title>SUMMARY<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Syphilis testing conventionally relies on a combination of non\u2010treponemal and treponemal tests. The primary objective of this study was to describe the positive predictive value (<jats:styled-content style=\"fixed-case\">PPV<\/jats:styled-content>) of a screening algorithm in a combination of a treponemal rapid diagnostic test (<jats:styled-content style=\"fixed-case\">RDT<\/jats:styled-content>) and rapid plasma reagin (<jats:styled-content style=\"fixed-case\">RPR<\/jats:styled-content>) test at Komfo Anokye Teaching Hospital (<jats:styled-content style=\"fixed-case\">KATH<\/jats:styled-content>), Ghana.<\/jats:p><\/jats:sec><jats:sec><jats:title>Materials and Methods<\/jats:title><jats:p>From February 2014 to January 2015, 5<jats:styled-content style=\"fixed-case\">mL<\/jats:styled-content>of venous blood samples were taken from 16\u2009016 blood donors and tested with a treponemal<jats:styled-content style=\"fixed-case\">RDT<\/jats:styled-content>; 5<jats:styled-content style=\"fixed-case\">mL<\/jats:styled-content>of venous blood was taken from 526 consenting initial syphilis sero\u2010reactive blood donors. These<jats:styled-content style=\"fixed-case\">RDT<\/jats:styled-content>reactive samples were confirmed with an algorithm, applying the Vitros<jats:sup>\u00ae<\/jats:sup>\/Abbott\u2010Architect<jats:sup>\u00ae<\/jats:sup>algorithm as gold standard.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A total of 478 of 526<jats:styled-content style=\"fixed-case\">RDT<\/jats:styled-content>reactive donors were confirmed positive for syphilis, making a<jats:styled-content style=\"fixed-case\">PPV<\/jats:styled-content>of 90\u00b79%. Of the 172 (32\u00b77%) donors who were also<jats:styled-content style=\"fixed-case\">RPR<\/jats:styled-content>positive, 167 were confirmed, resulting in a<jats:styled-content style=\"fixed-case\">PPV<\/jats:styled-content>of 97\u00b71%. The<jats:styled-content style=\"fixed-case\">PPV<\/jats:styled-content>of the combined<jats:styled-content style=\"fixed-case\">RDT<\/jats:styled-content>and<jats:styled-content style=\"fixed-case\">RPR<\/jats:styled-content>(suspected active syphilis) testing algorithm was highest among donors at an enhanced risk of syphilis, family\/replacement donors (99\u00b79%), and among voluntary donors above 25 years (98\u00b76%).<\/jats:p><\/jats:sec><jats:sec><jats:title>Discussion<\/jats:title><jats:p>Screening of blood donors by combining syphilis<jats:styled-content style=\"fixed-case\">RDT<\/jats:styled-content>and<jats:styled-content style=\"fixed-case\">RPR<\/jats:styled-content>with relatively good<jats:styled-content style=\"fixed-case\">PPV<\/jats:styled-content>may provide a reasonable technology for<jats:styled-content style=\"fixed-case\">LMIC<\/jats:styled-content>that has a limited capacity for testing and can contribute to the improvement of blood safety with a minimal loss of donors.<\/jats:p><\/jats:sec>","DOI":"10.1111\/tme.12363","type":"journal-article","created":{"date-parts":[[2016,10,13]],"date-time":"2016-10-13T09:52:42Z","timestamp":1476352362000},"page":"52-59","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Improving the screening of blood donors with syphilis rapid diagnostic test (<scp>RDT<\/scp>) and rapid plasma reagin (<scp>RPR<\/scp>) in low\u2010 and middle\u2010income countries (<scp>LMIC<\/scp>)"],"prefix":"10.1111","volume":"27","author":[{"given":"F.","family":"Sarkodie","sequence":"first","affiliation":[{"name":"Transfusion Medicine Unit Komfo Anokye Teaching Hospital Kumasi Ghana"},{"name":"Faculty of Health and Life Sciences Liverpool School of Tropical Medicine Liverpool UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"O.","family":"Hassall","sequence":"additional","affiliation":[{"name":"Faculty of Health and Life Sciences Liverpool School of Tropical Medicine Liverpool UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"E.","family":"Owusu\u2010Dabo","sequence":"additional","affiliation":[{"name":"School of Public Health School of Medical Sciences, Kwame Nkrumah University of Science and Technology Kumasi Ghana"},{"name":"Kumasi Centre for Collaborative Research Kwame Nkrumah University of Science and Technology Kumasi Ghana"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S.","family":"Owusu\u2010Ofori","sequence":"additional","affiliation":[{"name":"Transfusion Medicine Unit Komfo Anokye Teaching Hospital Kumasi Ghana"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"I.","family":"Bates","sequence":"additional","affiliation":[{"name":"Faculty of Health and Life Sciences Liverpool School of Tropical Medicine Liverpool UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"I. 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