{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,13]],"date-time":"2025-11-13T07:08:03Z","timestamp":1763017683601},"reference-count":17,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2016,10,11]],"date-time":"2016-10-11T00:00:00Z","timestamp":1476144000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Transfusion Medicine"],"published-print":{"date-parts":[[2017,2]]},"abstract":"<jats:title>SUMMARY<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Collection of peripheral blood stem cells (PBSCs) for autologous transplantation is a well\u2010established process. As a new generation of leukapheresis (LP) machines has been launched, measures of benchmarking and quality control need to be defined in order to ensure consistent collection performance.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objectives<\/jats:title><jats:p>The goal of this project was to establish and evaluate a benchmarking system for autologous PBSC collection.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This retrospective study evaluated PBSC collection data of 198 patients with symptomatic multiple myeloma in first\u2010line therapy who underwent LP in 2013 and 2014 at our institution. Half the patients in 2014 were assigned randomly to undergo LP with the new Terumo BCT Spectra Optia (Terumo BCT, Garching, Germany), while the COBE Spectra (Terumo BCT) was used in all other cases. In 2014, we implemented a previously described formula for predicting daily CD34+ cell collection. As a benchmark, we developed the performance ratio: collected\/predicted CD34+ cells.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>There was no significant difference in the number of collected CD34+ cells, the collection efficiency (collected\/processed CD34+ cells) and performance ratio between the two collection devices and between LP procedures in 2013 and 2014.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>We present a comprehensive benchmarking tool that is easy to implement, requires minimal expense and allows specific adjustment of LP parameters for optimisation of LP performance. With this approach, we could confirm the equal efficiency of the two compared apheresis systems.<\/jats:p><\/jats:sec>","DOI":"10.1111\/tme.12367","type":"journal-article","created":{"date-parts":[[2016,10,13]],"date-time":"2016-10-13T14:57:00Z","timestamp":1476370620000},"page":"36-42","update-policy":"http:\/\/dx.doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":21,"title":["Performance assessment and benchmarking of autologous peripheral blood stem cell collection with two different apheresis devices"],"prefix":"10.1111","volume":"27","author":[{"given":"P.","family":"Wuchter","sequence":"first","affiliation":[{"name":"Department of Medicine V Heidelberg University  Heidelberg Germany"},{"name":"Institute of Transfusion Medicine and Immunology, Mannheim, German Red Cross Blood Donor Service Baden\u2010W\u00fcrttemberg \u2013 Hessen, Medical Faculty Mannheim Heidelberg University  Heidelberg Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.","family":"Hundemer","sequence":"additional","affiliation":[{"name":"Department of Medicine V Heidelberg University  Heidelberg Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A.","family":"Schmitt","sequence":"additional","affiliation":[{"name":"Department of Medicine V Heidelberg University  Heidelberg Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.","family":"Witzens\u2010Harig","sequence":"additional","affiliation":[{"name":"Department of Medicine V Heidelberg University  Heidelberg Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"P.","family":"Pavel","sequence":"additional","affiliation":[{"name":"Stem Cell Laboratory IKTZ Heidelberg GmbH  Heidelberg Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J.","family":"Hillengass","sequence":"additional","affiliation":[{"name":"Department of Medicine V Heidelberg University  Heidelberg Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"H.","family":"Goldschmidt","sequence":"additional","affiliation":[{"name":"Department of Medicine V Heidelberg University  Heidelberg Germany"},{"name":"National Center for Tumor Diseases Heidelberg (NCT)  Heidelberg Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A. D.","family":"Ho","sequence":"additional","affiliation":[{"name":"Department of Medicine V Heidelberg University  Heidelberg Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"K.","family":"Lisenko","sequence":"additional","affiliation":[{"name":"Department of Medicine V Heidelberg University  Heidelberg Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2016,10,11]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/jca.21313"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/trf.12813"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/jca.21380"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-1-4614-1960-0_8"},{"key":"e_1_2_7_6_1","first-page":"21","article-title":"\u2018Will I have enough cells for a transplant, doctor?\u2019 Validation of a CD34+ dose prediction formula using patient weight, peripheral CD34+ count and predicted end\u2010run results in a series of 440 consecutive PBSC collection procedures using the MNC program on COBE Spectra","volume":"23","author":"Douglas K.W.","year":"2008","journal-title":"Journal of Clinical Apheresis"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/trf.12435"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1002\/jca.21323"},{"key":"e_1_2_7_9_1","article-title":"Comparison between intermittent and continuous spectra optia leukapheresis systems for autologous peripheral blood stem cell collection","author":"Lisenko K.","year":"2016","journal-title":"Journal of Clinical Apheresis"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1423-0410.1996.7120090.x"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.exphem.2011.05.004"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1038\/bmt.2014.39"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1423-0410.2006.00796.x"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.3109\/14653249.2011.652733"},{"key":"e_1_2_7_15_1","doi-asserted-by":"crossref","first-page":"2458","DOI":"10.1182\/blood.V124.21.2458.2458","article-title":"Validation of a predictive formula for collection of hematopoietic progenitor cells (HPC) by leukapheresis at 2 institutions using 4 different machine protocols","volume":"124","author":"Rosenbaum E.R.","year":"2014","journal-title":"Blood"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.3109\/14653249.2012.681042"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1038\/bmt.2010.236"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbmt.2009.11.012"}],"container-title":["Transfusion Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Ftme.12367","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Ftme.12367","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/tme.12367","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,29]],"date-time":"2023-09-29T21:26:26Z","timestamp":1696022786000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/tme.12367"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,10,11]]},"references-count":17,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2017,2]]}},"alternative-id":["10.1111\/tme.12367"],"URL":"https:\/\/doi.org\/10.1111\/tme.12367","archive":["Portico"],"relation":{},"ISSN":["0958-7578","1365-3148"],"issn-type":[{"value":"0958-7578","type":"print"},{"value":"1365-3148","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,10,11]]},"assertion":[{"value":"2016-03-14","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2016-09-17","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2016-10-11","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}