{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,7,4]],"date-time":"2025-07-04T12:26:37Z","timestamp":1751631997130},"reference-count":33,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2016,10,11]],"date-time":"2016-10-11T00:00:00Z","timestamp":1476144000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Transfusion Medicine"],"published-print":{"date-parts":[[2017,2]]},"abstract":"<jats:title><jats:styled-content style=\"fixed-case\">SUMMARY<\/jats:styled-content><\/jats:title><jats:sec><jats:title>Objectives<\/jats:title><jats:p>The aim of this study was to assess the appropriateness of using combined cell index <jats:styled-content style=\"fixed-case\">(CCI)<\/jats:styled-content> in the assessment of iron stores in blood donors. This index is calculated by the formula: red blood cell distribution width (<jats:styled-content style=\"fixed-case\">RDW<\/jats:styled-content>) \u00d7 10<jats:sup>4<\/jats:sup> \u00d7 mean corpuscular volume (MCV)<jats:sup>\u22121<\/jats:sup> \u00d7 mean corpuscular haemoglobin (MCH)<jats:sup>\u22121<\/jats:sup>.<\/jats:p><\/jats:sec><jats:sec><jats:title>Background<\/jats:title><jats:p>Ferritin measurement is a reliable method for estimating iron stores in blood donors. The sensitivity of red blood cell (<jats:styled-content style=\"fixed-case\">RBC<\/jats:styled-content>) parameters of complete blood count in detecting non\u2010anaemic iron deficiency is significantly lower. Consequently, there were several attempts to increase the detection sensitivity by combining these parameters in different indices.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This study included 1084 male and 792 female whole blood donors accepted for blood donation. For six <jats:styled-content style=\"fixed-case\">RBC<\/jats:styled-content> parameters with the highest level of correlation relative to ferritin [Hgb, <jats:styled-content style=\"fixed-case\">MCV<\/jats:styled-content>, <jats:styled-content style=\"fixed-case\">MCH<\/jats:styled-content>, mean corpuscular haemoglobin concentration (<jats:styled-content style=\"fixed-case\">MCHC<\/jats:styled-content>), <jats:styled-content style=\"fixed-case\">RDW<\/jats:styled-content> and <jats:styled-content style=\"fixed-case\">CCI<\/jats:styled-content>], diagnostic efficacy in the detection of iron depletion (ferritin &lt;12\u2009\u00b5g\u2009L<jats:sup>\u22121<\/jats:sup>) was assessed using receiver operating characteristic (<jats:styled-content style=\"fixed-case\">ROC<\/jats:styled-content>) analysis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p><jats:styled-content style=\"fixed-case\">CCI<\/jats:styled-content> showed the highest degree of correlation with ferritin (<jats:italic>r<\/jats:italic>\u2009=\u2009\u22120\u00b7373 for men and <jats:italic>r<\/jats:italic>\u2009=\u2009\u22120\u00b7590 for women) and the highest area under the curve (0\u00b7961 for men and 0\u00b7864 for women). Using the cut\u2010off value of 52\u00b76 for men and 50\u00b76 for women, the corresponding Youden index was the highest for <jats:styled-content style=\"fixed-case\">CCI<\/jats:styled-content> in both genders (0\u00b7851 for men and 0\u00b7612 for women). The sensitivity and specificity of <jats:styled-content style=\"fixed-case\">CCI<\/jats:styled-content> in the population of male donors were higher in comparison to female donors (0\u00b7941 and 0\u00b7910 vs 0\u00b7851 and 0\u00b7761, respectively).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Study results confirmed the satisfactory diagnostic value of <jats:styled-content style=\"fixed-case\">CCI<\/jats:styled-content> in detecting depleted iron stores in blood donors.<\/jats:p><\/jats:sec>","DOI":"10.1111\/tme.12370","type":"journal-article","created":{"date-parts":[[2016,10,13]],"date-time":"2016-10-13T15:12:31Z","timestamp":1476371551000},"page":"16-24","update-policy":"http:\/\/dx.doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Combined cell index in assessing blood donor iron stores"],"prefix":"10.1111","volume":"27","author":[{"given":"T.","family":"Vuk","sequence":"first","affiliation":[{"name":"Quality Management Croatian Institute of Transfusion Medicine  Zagreb Croatia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J.","family":"Bingulac\u2010Popovi\u0107","sequence":"additional","affiliation":[{"name":"Quality Management Croatian Institute of Transfusion Medicine  Zagreb Croatia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"T.","family":"O\u010di\u0107","sequence":"additional","affiliation":[{"name":"Quality Management Croatian Institute of Transfusion Medicine  Zagreb Croatia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"L. 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