{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,12]],"date-time":"2026-03-12T04:08:46Z","timestamp":1773288526743,"version":"3.50.1"},"reference-count":19,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2016,10,12]],"date-time":"2016-10-12T00:00:00Z","timestamp":1476230400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Transfusion Medicine"],"published-print":{"date-parts":[[2017,2]]},"abstract":"<jats:title>SUMMARY<\/jats:title><jats:sec><jats:title>Background\/Objectives<\/jats:title><jats:p>The safety of administering uncrossmatched, group O, cold\u2010stored, whole blood (<jats:styled-content style=\"fixed-case\">cWB<\/jats:styled-content>) during civilian trauma resuscitation was evaluated.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods\/Materials<\/jats:title><jats:p>Male trauma patients with haemorrhage\u2010induced hypotension who received leuko\u2010reduced uncrossmatched group O+, low titre (&lt;50) anti\u2010A and \u2010B, platelet\u2010replete <jats:styled-content style=\"fixed-case\">cWB<\/jats:styled-content> during initial resuscitation were included. The biochemical markers of haemolysis (lactate dehydrogenase, total bilirubin, haptoglobin, creatinine, serum potassium) were measured on the day of <jats:styled-content style=\"fixed-case\">cWB<\/jats:styled-content> receipt (day 0), and over the next 2 days, reports of transfusion reactions and total blood product administration in first 24 h of admission were recorded.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>There were 27 non\u2010group O and 17 group O <jats:styled-content style=\"fixed-case\">cWB<\/jats:styled-content> recipients. The median number of <jats:styled-content style=\"fixed-case\">cWB<\/jats:styled-content> units transfused was 1 [interquartile range (<jats:styled-content style=\"fixed-case\">IQR<\/jats:styled-content>): 1\u20132] in both groups. The median day 0 post\u2010transfusion serum total bilirubin concentration, although still in the normal range, was higher in the non\u2010group O versus group O recipients (1\u00b74 versus 0\u00b75 mg\/<jats:styled-content style=\"fixed-case\">dL<\/jats:styled-content>, <jats:italic>P<\/jats:italic> &lt; 0\u00b701). There were no significant differences in any of the other biochemical parameters at any other time point. Non\u2010group O recipients received a median of 3 times more red blood cell (<jats:styled-content style=\"fixed-case\">RBC<\/jats:styled-content>) units compared with group O recipients (<jats:italic>P<\/jats:italic> = 0\u00b701 <jats:styled-content style=\"fixed-case\">RBCs<\/jats:styled-content>), likely explaining the bilirubin difference on day 0. The median volume of <jats:styled-content style=\"fixed-case\">ABO<\/jats:styled-content>\u2010incompatible plasma transfused to non\u2010group O recipients was 600 <jats:styled-content style=\"fixed-case\">mL<\/jats:styled-content> (<jats:styled-content style=\"fixed-case\">IQR<\/jats:styled-content>: 300\u20131140 <jats:styled-content style=\"fixed-case\">mL<\/jats:styled-content>). There were no reports of adverse events related to the <jats:styled-content style=\"fixed-case\">cWB<\/jats:styled-content> transfusion in either group.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Administration of \u22642 units of <jats:styled-content style=\"fixed-case\">cWB<\/jats:styled-content> in civilian trauma resuscitation was not associated with clinically significant changes in laboratory haemolysis markers. Efficacy will be determined when larger quantities are transfused.<\/jats:p><\/jats:sec>","DOI":"10.1111\/tme.12372","type":"journal-article","created":{"date-parts":[[2016,10,13]],"date-time":"2016-10-13T18:42:22Z","timestamp":1476384142000},"page":"30-35","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":109,"title":["Measurement of haemolysis markers following transfusion of uncrossmatched, low\u2010titre, group O+ whole blood in civilian trauma patients: initial experience at a level 1 trauma centre"],"prefix":"10.1111","volume":"27","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6850-7495","authenticated-orcid":false,"given":"J. N.","family":"Seheult","sequence":"first","affiliation":[{"name":"Department of Pathology University of Pittsburgh  Pittsburgh Pennsylvania USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"D. J.","family":"Triulzi","sequence":"additional","affiliation":[{"name":"Department of Pathology University of Pittsburgh  Pittsburgh Pennsylvania USA"},{"name":"The Institute for Transfusion Medicine University of Pittsburgh  Pittsburgh Pennsylvania USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"L. H.","family":"Alarcon","sequence":"additional","affiliation":[{"name":"Department of Surgery University of Pittsburgh  Pittsburgh Pennsylvania USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J. L.","family":"Sperry","sequence":"additional","affiliation":[{"name":"Department of Surgery University of Pittsburgh  Pittsburgh Pennsylvania USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A.","family":"Murdock","sequence":"additional","affiliation":[{"name":"Department of Surgery University of Pittsburgh  Pittsburgh Pennsylvania USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M. H.","family":"Yazer","sequence":"additional","affiliation":[{"name":"Department of Pathology University of Pittsburgh  Pittsburgh Pennsylvania USA"},{"name":"The Institute for Transfusion Medicine University of Pittsburgh  Pittsburgh Pennsylvania USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2016,10,12]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1097\/00005373-197403000-00001"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/trf.12045"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1097\/SLA.0b013e3182a4ffa0"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1537-2995.2009.02208.x"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1097\/MOH.0b013e328358b135"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/anae.13071"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1537-2995.2010.02772.x"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.transci.2009.10.013"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1097\/TA.0000000000000354"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1053\/tmrv.2003.50003"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0378-4347(00)83879-7"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1097\/TA.0000000000000327"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1111\/trf.12048"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1097\/SHK.0000000000000082"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1097\/TA.0000000000000628"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1111\/trf.13448"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1097\/TA.0000000000001100"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1111\/trf.13399"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.surg.2014.01.017"}],"container-title":["Transfusion Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Ftme.12372","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Ftme.12372","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/tme.12372","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,29]],"date-time":"2023-09-29T21:26:18Z","timestamp":1696022778000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/tme.12372"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,10,12]]},"references-count":19,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2017,2]]}},"alternative-id":["10.1111\/tme.12372"],"URL":"https:\/\/doi.org\/10.1111\/tme.12372","archive":["Portico"],"relation":{},"ISSN":["0958-7578","1365-3148"],"issn-type":[{"value":"0958-7578","type":"print"},{"value":"1365-3148","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,10,12]]},"assertion":[{"value":"2016-07-22","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2016-09-23","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2016-10-12","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}