{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,29]],"date-time":"2025-10-29T13:27:11Z","timestamp":1761744431736},"reference-count":10,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2017,1,19]],"date-time":"2017-01-19T00:00:00Z","timestamp":1484784000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Transfusion Medicine"],"published-print":{"date-parts":[[2017,4]]},"abstract":"<jats:title>SUMMARY<\/jats:title><jats:sec><jats:title>Objectives<\/jats:title><jats:p>To estimate the current incidence of maternal sensitisation to Rhesus (Rh) D in Northern Ireland, examine adherence to recommendations for administration of anti\u2010D immunoglobulin and identify potential causes for all cases of anti\u2010D alloimmunisation sensitisation from January 2010 to September 2015.<\/jats:p><\/jats:sec><jats:sec><jats:title>Background<\/jats:title><jats:p>Post\u2010partum anti\u2010D immunoglobulin administered to Rh D\u2010negative women and routine antenatal anti\u2010D prophylaxis have greatly reduced the incidence of haemolytic disease of the fetus and newborn due to immune anti\u2010D. Despite these measures, anti\u2010D alloimmunisation sensitisation continues to occur, albeit much less frequently than in the past.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods\/Materials<\/jats:title><jats:p>This was a retrospective review of new sensitisations to Rh D detected in antenatal records between January 2010 and September 2015 in Northern Ireland. A review of patient notes and laboratory data was carried out to examine adherence to standards and identify potential causes of sensitisation.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A total of 67 new sensitisations to Rh D were identified over a 69\u2010month period, and the sensitisation rate for the full calendar years 2010\u20132014 was 0\u00b7310%. Only 4% of cases appear to have been preventable, with two cases involving failure to adhere to guidelines.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>A total 96% of sensitisations occurred despite full compliance with guidelines. In a large proportion, sensitisation occurred following delivery (51%). A change in practice in Northern Ireland is under consideration to increase the dose of anti\u2010D immunoglobulin given following delivery from 500 to 1500 U in an attempt to reduce these sensitisations.<\/jats:p><\/jats:sec>","DOI":"10.1111\/tme.12387","type":"journal-article","created":{"date-parts":[[2017,1,19]],"date-time":"2017-01-19T06:57:30Z","timestamp":1484809050000},"page":"132-135","update-policy":"http:\/\/dx.doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["A review of maternal alloimmunisation to Rh D in Northern Ireland"],"prefix":"10.1111","volume":"27","author":[{"given":"C. J.","family":"McCauley","sequence":"first","affiliation":[{"name":"Department of Haematology Belfast City Hospital  Belfast UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"K.","family":"Morris","sequence":"additional","affiliation":[{"name":"Transfusion Medicine Northern Ireland Blood Transfusion Service  Belfast UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"K.","family":"Maguire","sequence":"additional","affiliation":[{"name":"Transfusion Medicine Northern Ireland Blood Transfusion Service  Belfast UK"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2017,1,19]]},"reference":[{"key":"e_1_2_7_2_1","unstructured":"European Medicines Agency(2016)Guideline on the core SmPC for human anti\u2010D immunoglobulin for intramuscular use[ONLINE]. URLhttp:\/\/www.ema.europa.eu\/docs\/en_GB\/document_library\/Scientific_guideline\/2016\/09\/WC500213199.pdf(Accessed 18\/12\/16)."},{"issue":"9","key":"e_1_2_7_3_1","doi-asserted-by":"crossref","first-page":"765","DOI":"10.1016\/S1701-2163(16)31006-4","article-title":"Prevention of Rh alloimmunization","volume":"25","author":"Fung\u2010Kee\u2010Fung K.","year":"2003","journal-title":"Journal of Obstetrics and Gynaecology Canada"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1471-0528.2009.02244.x"},{"key":"e_1_2_7_5_1","first-page":"CD000020","article-title":"Anti\u2010D administration in pregnancy for preventing Rhesus alloimmunisation","volume":"9","author":"McBain R.D.","year":"2015","journal-title":"The Cochrane Database of Systematic Reviews"},{"key":"e_1_2_7_6_1","unstructured":"National Institute for Clinical and Healthcare Excellence(2015)Diagnostics Assessment Programme High\u2010throughput non\u2010invasive prenatal testing (NIPT) for fetal rhesus D status[ONLINE]. URLhttps:\/\/www.nice.org.uk\/guidance\/GID\u2010DT29\/documents\/final\u2010scope(Accessed 19\/08\/16)."},{"key":"e_1_2_7_7_1","unstructured":"National Institute for Clinical and Healthcare Excellence(2008)Routine antenatal anti\u2010D prophylaxis for women who are rhesus D negative|Guidance and guidelines|NICE[ONLINE]. URLhttps:\/\/www.nice.org.uk\/guidance\/ta156(Accessed 19\/08\/16)."},{"key":"e_1_2_7_8_1","unstructured":"Northern Ireland Statistics and Research Agency(2015)NISRA \u2013 Demography[ONLINE]. URLhttp:\/\/www.nisra.gov.uk\/demography\/default.asp8.htm. (Accessed 19\/08\/16)."},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.3310\/hta13100"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/tme.12091"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0030711"}],"container-title":["Transfusion Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Ftme.12387","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/tme.12387","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,29]],"date-time":"2023-09-29T22:45:18Z","timestamp":1696027518000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/tme.12387"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,1,19]]},"references-count":10,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2017,4]]}},"alternative-id":["10.1111\/tme.12387"],"URL":"https:\/\/doi.org\/10.1111\/tme.12387","archive":["Portico"],"relation":{},"ISSN":["0958-7578","1365-3148"],"issn-type":[{"value":"0958-7578","type":"print"},{"value":"1365-3148","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,1,19]]},"assertion":[{"value":"2016-08-22","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2016-12-26","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2017-01-19","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}