{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,20]],"date-time":"2026-07-20T15:05:08Z","timestamp":1784559908017,"version":"3.55.0"},"reference-count":21,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2017,2,23]],"date-time":"2017-02-23T00:00:00Z","timestamp":1487808000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Transfusion Medicine"],"published-print":{"date-parts":[[2017,6]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:sec><jats:title>Objectives<\/jats:title><jats:p>We propose to analyse the positive and false\u2010positive results of treponemal and nontreponemal tests in blood donors from Brazil and to evaluate possible factors associated with the results of treponemal tests.<\/jats:p><\/jats:sec><jats:sec><jats:title>Background<\/jats:title><jats:p>Treponemal tests have been used widely for syphilis screening in blood banks. The introduction of these tests in donor screening has caused an impact and a loss of donors who need to be assessed.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This was a retrospective cross\u2010sectional study of syphilis screening and confirmatory test results of blood donors that were obtained before and after adopting a chemiluminescent immunoassay (<jats:styled-content style=\"fixed-case\">CLIA<\/jats:styled-content>). A comparative analysis was performed using a second sample drawn from positive donors. The possible factors associated with <jats:styled-content style=\"fixed-case\">CLIA<\/jats:styled-content>\u2010positive or <jats:styled-content style=\"fixed-case\">CLIA<\/jats:styled-content>\u2010false\u2010positive results were investigated in a subgroup. Statistical tests were used to compare the proportions and adjusted estimates of association.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The reactivity rate increased from 1\u00b701% (<jats:italic>N<\/jats:italic> = 28 158) to 2\u00b766% (<jats:italic>N<\/jats:italic> = 25 577) after introducing the new test. Among Venereal Disease Research Laboratory (<jats:styled-content style=\"fixed-case\">VDRL<\/jats:styled-content>)\u2010 and <jats:styled-content style=\"fixed-case\">CLIA<\/jats:styled-content>\u2010confirmed results, the false\u2010positive rates were 40\u00b75% (<jats:italic>N<\/jats:italic> = 180) and 37\u00b74% (<jats:italic>N<\/jats:italic> = 359), respectively (<jats:italic>P<\/jats:italic> = 0\u00b75266). Older donors (<jats:styled-content style=\"fixed-case\">OR<\/jats:styled-content> = 1\u00b704; <jats:italic>P<\/jats:italic> = 0\u00b70010) and donors with lower education levels (<jats:styled-content style=\"fixed-case\">OR<\/jats:styled-content> = 6\u00b759; <jats:italic>P<\/jats:italic> = 0\u00b70029) were associated with a higher risk of positivity for syphilis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p><jats:styled-content style=\"fixed-case\">CLIA<\/jats:styled-content> represents an improvement in blood bank serological screening. However, its use in a healthy population appears to result in high rates of false positives. Identifying which characteristics can predict false positives, however, remains a challenge.<\/jats:p><\/jats:sec>","DOI":"10.1111\/tme.12395","type":"journal-article","created":{"date-parts":[[2017,2,23]],"date-time":"2017-02-23T10:52:38Z","timestamp":1487847158000},"page":"200-206","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Evaluation of positive and false\u2010positive results in syphilis screening of blood donors in Rio de Janeiro, Brazil"],"prefix":"10.1111","volume":"27","author":[{"given":"V. S.","family":"Sandes","sequence":"first","affiliation":[{"name":"Servi\u00e7o de Hemoterapia Instituto Nacional de C\u00e2ncer Jos\u00e9 Alencar Gomes da Silva  Rio de Janeiro Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S. G. C.","family":"Silva","sequence":"additional","affiliation":[{"name":"Servi\u00e7o de Hemoterapia Instituto Nacional de C\u00e2ncer Jos\u00e9 Alencar Gomes da Silva  Rio de Janeiro Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"I. J. F.","family":"Motta","sequence":"additional","affiliation":[{"name":"Servi\u00e7o de Hemoterapia Instituto Nacional de C\u00e2ncer Jos\u00e9 Alencar Gomes da Silva  Rio de Janeiro Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L. G. C.","family":"Velarde","sequence":"additional","affiliation":[{"name":"Departamento de Estat\u00edstica Universidade Federal Fluminense  Niter\u00f3i Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S. R.","family":"de Castilho","sequence":"additional","affiliation":[{"name":"Faculdade de Farm\u00e1cia Universidade Federal Fluminense  Niter\u00f3i Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2017,2,23]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1537-2995.2008.01977.x"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/tme.12095"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clindermatol.2007.09.020"},{"key":"e_1_2_7_5_1","unstructured":"Brazil. (2016). Ministry of Health. 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