{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,21]],"date-time":"2026-09-21T04:10:12Z","timestamp":1789963812953,"version":"4.0.1"},"reference-count":103,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2017,4,6]],"date-time":"2017-04-06T00:00:00Z","timestamp":1491436800000},"content-version":"vor","delay-in-days":5,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Transfusion Medicine"],"published-print":{"date-parts":[[2017,4]]},"abstract":"<jats:title>SUMMARY<\/jats:title>\n                  <jats:p>\n                    The hepatitis E virus (\n                    <jats:styled-content style=\"fixed-case\">HEV<\/jats:styled-content>\n                    ) is a major cause of acute hepatitis globally. Genotypes 1 and 2 (\n                    <jats:styled-content style=\"fixed-case\">G1<\/jats:styled-content>\n                    and\n                    <jats:styled-content style=\"fixed-case\">G2<\/jats:styled-content>\n                    ) are obligate human pathogens transmitted faeco\u2010orally, leading to epidemics in developing countries. In contrast, genotypes 3 and 4 (\n                    <jats:styled-content style=\"fixed-case\">G3<\/jats:styled-content>\n                    and\n                    <jats:styled-content style=\"fixed-case\">G4<\/jats:styled-content>\n                    ) have a wider host range, including humans, but are primarily porcine viruses and are transmitted from animals to humans as a food\u2010borne zoonosis when meat from an infected animal is consumed.\n                    <jats:styled-content style=\"fixed-case\">HEV<\/jats:styled-content>\n                    is increasingly recognised as a problem in developed countries, including countries in Europe.\n                    <jats:styled-content style=\"fixed-case\">G3 HEV<\/jats:styled-content>\n                    is now the most common cause of acute viral hepatitis in the\n                    <jats:styled-content style=\"fixed-case\">UK<\/jats:styled-content>\n                    and cases continue to rise. The majority of these infections are acquired within the\n                    <jats:styled-content style=\"fixed-case\">UK<\/jats:styled-content>\n                    and thought to be from insufficiently cooked meat, predominantly processed pork meat. Previously thought to only cause self\u2010limiting disease,\n                    <jats:styled-content style=\"fixed-case\">HEV<\/jats:styled-content>\n                    infection can persist in immunosuppressed patients, which may lead to chronic hepatitis and the rapid development of cirrhosis. Of particular interest to the transfusion community has been the possibility of transfusion\u2010transmitted\n                    <jats:styled-content style=\"fixed-case\">HEV<\/jats:styled-content>\n                    , which has been reported from countries classically considered\n                    <jats:styled-content style=\"fixed-case\">HEV<\/jats:styled-content>\n                    \u2010endemic but also non\u2010endemic countries in Europe and Japan. This has prompted some countries to introduce screening for\n                    <jats:styled-content style=\"fixed-case\">HEV<\/jats:styled-content>\n                    in blood donations.\n                  <\/jats:p>","DOI":"10.1111\/tme.12405","type":"journal-article","created":{"date-parts":[[2017,4,6]],"date-time":"2017-04-06T04:20:23Z","timestamp":1491452423000},"page":"84-95","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":50,"title":["Hepatitis E: the current state of play"],"prefix":"10.1111","volume":"27","author":[{"given":"M. J.","family":"Ankcorn","sequence":"first","affiliation":[{"name":"Blood Borne Virus Unit, Virus Reference Department National Infection Service, Public Health England  London UK"},{"name":"Transfusion Microbiology National Health Service Blood and Transplant  London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R. 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