{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,10]],"date-time":"2026-07-10T13:04:27Z","timestamp":1783688667524,"version":"3.55.0"},"reference-count":12,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2017,4,12]],"date-time":"2017-04-12T00:00:00Z","timestamp":1491955200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Transfusion Medicine"],"published-print":{"date-parts":[[2017,8]]},"abstract":"<jats:title>SUMMARY<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>To determine if pegylated bovine carboxyhaemoglobin can be utilised in a thrombotic thrombocytopenic purpura (<jats:styled-content style=\"fixed-case\">TTP<\/jats:styled-content>) patient.<\/jats:p><\/jats:sec><jats:sec><jats:title>Background<\/jats:title><jats:p><jats:styled-content style=\"fixed-case\">TTP<\/jats:styled-content> is a condition characterized by thrombotic microangiopathy and has a high mortality rate when left untreated. Therapeutic plasma exchange is well established as the most effective and evidence\u2010based treatment of <jats:styled-content style=\"fixed-case\">TTP<\/jats:styled-content>.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>The ability to administer plasma exchange therapy is limited in Jehovah's Witnesses who decline blood products due to religious beliefs. Pegylated bovine carboxyhaemoglobin is a novel oxygen transfer agent in development for the management of complications of ischaemia due to acute anaemia.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Treatment was well tolerated, with grade 1 paresthesia of the right face and arm 1\u2009h after the first infusion of Sanguinate, which spontaneously resolved and did not recur, and grade 1 cardiac troponin elevation after receiving the medication (with peak at 0\u00b7079 ng\u2009mL<jats:sup>\u22121<\/jats:sup>), but further workup with electrocardiogram and echocardiogram was unremarkable. By discharge on day 19, the patient's haemoglobin increased to 8\u00b78 g\u2009dL<jats:sup>\u22121<\/jats:sup> and platelet count to 221\u2009000.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>We report the first case of <jats:styled-content style=\"fixed-case\">TTP<\/jats:styled-content> in a Jehovah's Witness that was successfully managed with the use of pegylated bovine carboxyhaemoglobin as an adjunct medication.<\/jats:p><\/jats:sec>","DOI":"10.1111\/tme.12407","type":"journal-article","created":{"date-parts":[[2017,4,12]],"date-time":"2017-04-12T08:04:50Z","timestamp":1491984290000},"page":"300-302","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":21,"title":["Pegylated bovine carboxyhaemoglobin utilisation in a thrombotic thrombocytopenic purpura patient"],"prefix":"10.1111","volume":"27","author":[{"given":"C.","family":"Sam","sequence":"first","affiliation":[{"name":"Department of Hematology University of South Florida Morsani College of Medicine  Tampa Florida USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P.","family":"Desai","sequence":"additional","affiliation":[{"name":"Department of Hematology University of South Florida Morsani College of Medicine  Tampa Florida USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D.","family":"Laber","sequence":"additional","affiliation":[{"name":"Department of Hematology University of South Florida Morsani College of Medicine  Tampa Florida USA"},{"name":"Department of Hematology &amp; 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