{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,21]],"date-time":"2026-05-21T00:45:39Z","timestamp":1779324339139,"version":"3.51.4"},"reference-count":18,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2017,4,10]],"date-time":"2017-04-10T00:00:00Z","timestamp":1491782400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Transfusion Medicine"],"published-print":{"date-parts":[[2017,10]]},"abstract":"SUMMARY<\/jats:title>Background<\/jats:title>HLAMatchmaker<\/jats:styled-content> has been used in the Irish Blood Transfusion Service (IBTS<\/jats:styled-content>) to select platelets for HLA<\/jats:styled-content>\u2010alloimmunised, platelet refractory thrombocytopaenic patients since 2006. Although available since 2002, only three studies have been published supporting the programme's effectiveness for this indication.<\/jats:p><\/jats:sec>Objectives<\/jats:title>We sought to examine increments to HLA<\/jats:styled-content>\u2010matched platelets (HMPs<\/jats:styled-content>) at various matchmaker scores and to examine the impact of transfusing older platelets and ABO<\/jats:styled-content>\u2010mismatched platelets to this patient group.<\/jats:p><\/jats:sec>Methods\/Materials<\/jats:title>A total of 20 consecutive HLA<\/jats:styled-content>\u2010alloimmunised thrombocytopaenic patients were retrospectively studied. Data collected included: pre\u2010 and post\u2010transfusion platelet count, indication for transfusion, HLAMatchmaker<\/jats:styled-content> score, age of unit and degree of ABO<\/jats:styled-content> mismatch. Data were also collected on the last 3\u2009U of (RDPs<\/jats:styled-content>). The Mann\u2013Whitney U<\/jats:italic>\u2010test was used to compare increments between transfusion episodes of random donor platelets (RDPs<\/jats:styled-content>) vs HMPs<\/jats:styled-content> with matchmaker scores <3, 4\u20137 or >8.<\/jats:p><\/jats:sec>Results<\/jats:title>Increments at <2\u2009h were available for 63 transfusion episodes. Increments at 2\u201324 h were available for 93 transfusion episodes. Increments were higher when transfusing HMPs<\/jats:styled-content> than when transfusing RDPs<\/jats:styled-content>. Increments for HMPs<\/jats:styled-content> that were ABO<\/jats:styled-content> mismatched were no different than for ABO<\/jats:styled-content>\u2010identical units, with the exception of late increments post\u2010transfusing HMPs<\/jats:styled-content> with a major ABO<\/jats:styled-content> mismatch. Age of platelets did not influence increments.<\/jats:p><\/jats:sec>Conclusion<\/jats:title>The use of HLAMatchmaker<\/jats:styled-content> to select platelet units for thrombocytopaenic HLA<\/jats:styled-content>\u2010alloimmunised patients produced satisfactory platelet increments. When providing HLAMatchmaker<\/jats:styled-content>\u2010selected HMPs<\/jats:styled-content>, ABO<\/jats:styled-content> mismatch and the use of platelet units that are up to 7 days old should be permissible.<\/jats:p><\/jats:sec>","DOI":"10.1111\/tme.12409","type":"journal-article","created":{"date-parts":[[2017,4,10]],"date-time":"2017-04-10T05:06:38Z","timestamp":1491800798000},"page":"369-374","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["HLAMatchmaker is effective for selecting appropriate platelet units for alloimmunised thrombocytopaenic patients who are refractory to random donor platelets"],"prefix":"10.1111","volume":"27","author":[{"given":"C.","family":"O'Rafferty","sequence":"first","affiliation":[{"name":"National Blood Centre, Irish Blood Transfusion Service National Histocompatibility and Immunogenetics Reference Laboratory Dublin Ireland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"G.","family":"Rooney","sequence":"additional","affiliation":[{"name":"National Blood Centre, Irish Blood Transfusion Service National Histocompatibility and Immunogenetics Reference Laboratory Dublin Ireland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1020-8983","authenticated-orcid":false,"given":"R.","family":"Hagan","sequence":"additional","affiliation":[{"name":"National Blood Centre, Irish Blood Transfusion Service National Histocompatibility and Immunogenetics Reference Laboratory Dublin Ireland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.","family":"Woolfson","sequence":"additional","affiliation":[{"name":"National Blood Centre, Irish Blood Transfusion Service National Histocompatibility and Immunogenetics Reference Laboratory Dublin Ireland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"D.","family":"O'Donghaile","sequence":"additional","affiliation":[{"name":"National Blood Centre, Irish Blood Transfusion Service National Histocompatibility and Immunogenetics Reference Laboratory Dublin Ireland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J.","family":"Fitzgerald","sequence":"additional","affiliation":[{"name":"National Blood Centre, Irish Blood Transfusion Service National Histocompatibility and Immunogenetics Reference Laboratory Dublin Ireland"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2017,4,10]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.trim.2005.01.001"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1537-2995.2008.01837.x"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajh.2830020303"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2141.1984.tb01267.x"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1537-2995.1994.34394196618.x"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.tp.0000205202.56915.f5"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1399-0012.2005.00473.x"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2141.2008.07189.x"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2004-10-4080"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1537-2995.1990.30490273438.x"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1537-2995.2010.02703.x"},{"key":"e_1_2_7_13_1","first-page":"194","article-title":"A solid\u2010phase red cell adherence test for platelet cross\u2010matching","volume":"42","author":"Rachel J. 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