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Measures to reduce the risk of <jats:styled-content style=\"fixed-case\">TT\u2010CMV<\/jats:styled-content> have been evaluated in clinical studies, including leucocyte depletion of cellular blood products and\/or the selection of <jats:styled-content style=\"fixed-case\">CMV\u2010IgG<\/jats:styled-content>\u2010negative donations. Studies in large blood donor cohorts indicate that donations from newly <jats:styled-content style=\"fixed-case\">CMV\u2010IgG<\/jats:styled-content>\u2010positive donors should bear the highest risk for transmitting <jats:styled-content style=\"fixed-case\">CMV<\/jats:styled-content> infections because they contain the highest levels of <jats:styled-content style=\"fixed-case\">CMV\u2010DNA<\/jats:styled-content>, and early <jats:styled-content style=\"fixed-case\">CMV<\/jats:styled-content> antibodies cannot neutralise <jats:styled-content style=\"fixed-case\">CMV<\/jats:styled-content>. Based on this knowledge, rational strategies to reduce the residual risk of <jats:styled-content style=\"fixed-case\">TT\u2010CMV<\/jats:styled-content> using leucoreduced blood products could be designed. However, there is a lack of evidence that <jats:styled-content style=\"fixed-case\">CMV<\/jats:styled-content> is still transmitted by transfusion of leucoreduced units. In low birthweight infants, most (if not all) <jats:styled-content style=\"fixed-case\">CMV<\/jats:styled-content> infections are caused by breast milk feeding or congenital transmission rather than by transfusion of leucoreduced blood products. For other patients at risk, no definitive data exist about the relative importance of alternative transmission routes of <jats:styled-content style=\"fixed-case\">CMV<\/jats:styled-content> compared to blood transfusion. As a result, only the conduction of well\u2010designed studies addressing strategies to prevent <jats:styled-content style=\"fixed-case\">TT\u2010CMV<\/jats:styled-content> and the thorough examination of presumed cases of <jats:styled-content style=\"fixed-case\">TT\u2010CMV<\/jats:styled-content> will achieve guidance for the best transfusion regimen in patients at risk.<\/jats:p>","DOI":"10.1111\/tme.12437","type":"journal-article","created":{"date-parts":[[2017,6,23]],"date-time":"2017-06-23T10:30:46Z","timestamp":1498213846000},"page":"238-248","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":48,"title":["Transfusion\u2010transmitted <scp>CMV<\/scp> infection\u00a0\u2013\u00a0current knowledge and future perspectives"],"prefix":"10.1111","volume":"27","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0919-0237","authenticated-orcid":false,"given":"M.","family":"Ziemann","sequence":"first","affiliation":[{"name":"Institut 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