{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,17]],"date-time":"2026-02-17T22:22:34Z","timestamp":1771366954092,"version":"3.50.1"},"reference-count":19,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2017,6,29]],"date-time":"2017-06-29T00:00:00Z","timestamp":1498694400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100007444","name":"Einar Willumsen Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100007444","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Transfusion Medicine"],"published-print":{"date-parts":[[2018,6]]},"abstract":"<jats:title><jats:styled-content style=\"fixed-case\">SUMMARY<\/jats:styled-content><\/jats:title><jats:sec><jats:title>Objectives<\/jats:title><jats:p>The primary objective of this feasibility study was to identify quality of life (<jats:styled-content style=\"fixed-case\">QoL<\/jats:styled-content>) scores and symptom scales as tools for measuring patient\u2010reported outcomes (<jats:styled-content style=\"fixed-case\">PRO<\/jats:styled-content>) associated with haemoglobin level in chemotherapy\u2010treated cancer patients. Secondary objectives included comparing <jats:styled-content style=\"fixed-case\">QoL<\/jats:styled-content> and symptoms between randomisation arms.<\/jats:p><\/jats:sec><jats:sec><jats:title>Background<\/jats:title><jats:p>Anaemia in cancer patients undergoing chemotherapy is associated with decreased <jats:styled-content style=\"fixed-case\">QoL<\/jats:styled-content>. One treatment option is red blood cell transfusion (<jats:styled-content style=\"fixed-case\">RBCT<\/jats:styled-content>). However, the optimal haemoglobin trigger for transfusion is unknown.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Patients were randomised to a haemoglobin trigger for <jats:styled-content style=\"fixed-case\">RBCT<\/jats:styled-content> of either\u2009&lt;\u20099\u00b77\u2009g\u2009<jats:styled-content style=\"fixed-case\">dL<\/jats:styled-content><jats:sup>\u22121<\/jats:sup> (arm A) or\u2009&lt;\u2009lower normal level, female: 11\u00b75\u2009g\u2009<jats:styled-content style=\"fixed-case\">dL<\/jats:styled-content><jats:sup>\u22121<\/jats:sup>, male: 13\u00b71\u2009g\u2009<jats:styled-content style=\"fixed-case\">dL<\/jats:styled-content><jats:sup>\u22121<\/jats:sup> (arm B). Four <jats:styled-content style=\"fixed-case\">PROs<\/jats:styled-content> were used: Functional Assessment of Cancer Therapy\u2010General (<jats:styled-content style=\"fixed-case\">FACT<\/jats:styled-content>\u2010G) and the <jats:styled-content style=\"fixed-case\">FACT<\/jats:styled-content>\u2010Anaemia (<jats:styled-content style=\"fixed-case\">FACT<\/jats:styled-content>\u2010An), a Numeric Rating Scale on symptoms of anaemia and self\u2010reported Performance Status (<jats:styled-content style=\"fixed-case\">PS<\/jats:styled-content>). The association between haemoglobin and <jats:styled-content style=\"fixed-case\">PRO<\/jats:styled-content> variables was assessed using a linear mixed model with random effects.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A total of 133 patients were enrolled, of which 86 patients received <jats:styled-content style=\"fixed-case\">RBCT<\/jats:styled-content> (28 in arm A, 58 in arm B). Baseline questionnaires were filled out in 79\u00b77% of cases. Haemoglobin levels were significantly correlated with <jats:styled-content style=\"fixed-case\">FACT<\/jats:styled-content>\u2010An, <jats:styled-content style=\"fixed-case\">FACT<\/jats:styled-content>\u2010An Total Outcome Index (<jats:styled-content style=\"fixed-case\">TOI<\/jats:styled-content>), Functional Well\u2010Being, fatigue and <jats:styled-content style=\"fixed-case\">PS<\/jats:styled-content>. Improvement on several <jats:styled-content style=\"fixed-case\">PRO<\/jats:styled-content> variables was observed in both arms after <jats:styled-content style=\"fixed-case\">RBCT<\/jats:styled-content>, with clinically minimal important differences observed in <jats:styled-content style=\"fixed-case\">FACT<\/jats:styled-content>\u2010G, Physical Well\u2010Being, <jats:styled-content style=\"fixed-case\">FACT<\/jats:styled-content>\u2010An, <jats:styled-content style=\"fixed-case\">FACT<\/jats:styled-content>\u2010An <jats:styled-content style=\"fixed-case\">TOI<\/jats:styled-content>, fatigue and dyspnoea.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>QoL scores of physical and functional domains as well as self\u2010reported anaemia\u2010related symptoms correlated well with haemoglobin level in chemotherapy\u2010treated cancer patients.<\/jats:p><\/jats:sec>","DOI":"10.1111\/tme.12439","type":"journal-article","created":{"date-parts":[[2017,6,29]],"date-time":"2017-06-29T10:02:41Z","timestamp":1498730561000},"page":"208-215","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":16,"title":["Randomised feasibility study of a more liberal haemoglobin trigger for red blood cell transfusion compared to standard practice in anaemic cancer patients treated with chemotherapy"],"prefix":"10.1111","volume":"28","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2086-1006","authenticated-orcid":false,"given":"D.","family":"Yakymenko","sequence":"first","affiliation":[{"name":"Department of Oncology Copenhagen University Hospital, Rigshospitalet  Copenhagen Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"K. B.","family":"Frandsen","sequence":"additional","affiliation":[{"name":"Department of Oncology Copenhagen University Hospital, Rigshospitalet  Copenhagen Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"I. J.","family":"Christensen","sequence":"additional","affiliation":[{"name":"Department of The Finsen Laboratory Copenhagen University Hospital, Rigshospitalet  Copenhagen Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A.","family":"Norgaard","sequence":"additional","affiliation":[{"name":"Department of Section for Transfusion Medicine Copenhagen University Hospital, Rigshospitalet  Copenhagen Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"P. I.","family":"Johansson","sequence":"additional","affiliation":[{"name":"Department of Section for Transfusion Medicine Copenhagen University Hospital, Rigshospitalet  Copenhagen Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"G.","family":"Daugaard","sequence":"additional","affiliation":[{"name":"Department of Oncology Copenhagen University Hospital, Rigshospitalet  Copenhagen Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.","family":"Mau\u2010Sorensen","sequence":"additional","affiliation":[{"name":"Department of Oncology Copenhagen University Hospital, Rigshospitalet  Copenhagen Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2017,6,29]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0761-8425(07)91010-4"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(20010615)91:12<2214::AID-CNCR1251>3.0.CO;2-P"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1093\/annonc\/mdh235"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.10763"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.bjc.6600657"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1097-0142(19991015)86:8<1528::AID-CNCR20>3.0.CO;2-E"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1093\/jnci\/91.19.1616"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.6004\/jnccn.2010.0133"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2001.19.11.2865"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejca.2004.06.019"},{"key":"e_1_2_7_12_1","first-page":"509","article-title":"Monitoring compliance with transfusion guidelines in hospital departments by electronic data capture","volume":"12","author":"Norgaard A.","year":"2014","journal-title":"Blood Transfusion"},{"key":"e_1_2_7_13_1","doi-asserted-by":"crossref","first-page":"593","DOI":"10.1097\/01.MLR.0000062554.74615.4C","article-title":"Interpretation of changes in health\u2010related quality of life: the remarkable universality of half a standard deviation","volume":"41","author":"Norman G.R.","year":"2003","journal-title":"Medical Care"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ctrv.2016.03.010"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1200\/JOP.2010.000132"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.hoc.2016.01.001"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1093\/annonc\/mdq202"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1186\/1477-7525-1-79"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0885-3924(96)00274-6"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.2147\/CLEP.S17146"}],"container-title":["Transfusion Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Ftme.12439","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/tme.12439","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,22]],"date-time":"2023-09-22T19:25:01Z","timestamp":1695410701000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/tme.12439"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,6,29]]},"references-count":19,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2018,6]]}},"alternative-id":["10.1111\/tme.12439"],"URL":"https:\/\/doi.org\/10.1111\/tme.12439","archive":["Portico"],"relation":{},"ISSN":["0958-7578","1365-3148"],"issn-type":[{"value":"0958-7578","type":"print"},{"value":"1365-3148","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,6,29]]},"assertion":[{"value":"2016-10-01","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2017-06-01","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2017-06-29","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}