{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T01:23:05Z","timestamp":1787016185419,"version":"build-2736575974"},"reference-count":10,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2018,1,25]],"date-time":"2018-01-25T00:00:00Z","timestamp":1516838400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Transfusion Medicine"],"published-print":{"date-parts":[[2019,6]]},"abstract":"<jats:title>SUMMARY<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>To report our 2\u00a0years of experience navigating the interference of anti\u2010CD38 monoclonal antibodies (MAs) in 33 patients and describe papain\u2010treated panels as a complementary method to dithiothreitol (DTT).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Novel anti\u2010CD38 MAs are now approved or undergoing clinical trials to evaluate their activity in patients with multiple myeloma. A concern with the use of these drugs is that they interfere with blood bank tests in a group of patients who often require blood transfusions.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Clinical data and whole blood samples were collected from patients receiving daratumumab or isatuximab. Routine blood bank serological tests were performed.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>A total of 9\u00b71% of patients presented with alloantibodies prior to treatment. All patients exhibited nonspecific reactivity in indirect antiglobulin tests, and 26% had positive direct antiglobulin tests after beginning treatment. This interference disappeared in all patients after discontinuing treatment. Papain panels avoided this reactivity and allowed us to identify alloantibodies. Phenotyped blood units were transfused, and no patient suffered any transfusion\u2010related complications.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Anti\u2010CD38 MAs produce nonspecific interference in blood bank tests. This interference can be overcome by various methods, including DTT or papain treatment as proposed here. These methods have limitations that can be resolved using phenotyped blood units.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/tme.12508","type":"journal-article","created":{"date-parts":[[2018,1,25]],"date-time":"2018-01-25T04:02:51Z","timestamp":1516852971000},"page":"193-196","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":19,"title":["Papain\u2010treated panels are a simple method for the identification of alloantibodies in multiple myeloma patients treated with anti\u2010CD38\u2010based therapies"],"prefix":"10.1111","volume":"29","author":[{"given":"G.","family":"Carre\u00f1o\u2010Tarragona","sequence":"first","affiliation":[{"name":"Department of Hematology Hospital Universitario 12 de Octubre, Universidad Complutense, CNIO  Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"T.","family":"Cedena","sequence":"additional","affiliation":[{"name":"Department of Hematology Hospital Universitario 12 de Octubre, Universidad Complutense, CNIO  Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L.","family":"Montejano","sequence":"additional","affiliation":[{"name":"Department of Hematology Hospital Universitario 12 de Octubre, Universidad Complutense, CNIO  Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R.","family":"Alonso","sequence":"additional","affiliation":[{"name":"Department of Hematology Hospital Universitario 12 de Octubre, Universidad Complutense, CNIO  Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"F.","family":"Miras","sequence":"additional","affiliation":[{"name":"Department of Hematology Hospital Universitario 12 de Octubre, Universidad Complutense, CNIO  Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"Valeri","sequence":"additional","affiliation":[{"name":"Department of Hematology Hospital Universitario 12 de Octubre, Universidad Complutense, CNIO  Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"Rivero","sequence":"additional","affiliation":[{"name":"Department of Hematology Hospital Universitario 12 de Octubre, Universidad Complutense, CNIO  Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J. J.","family":"Lahuerta","sequence":"additional","affiliation":[{"name":"Department of Hematology Hospital Universitario 12 de Octubre, Universidad Complutense, CNIO  Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7908-0063","authenticated-orcid":false,"given":"J.","family":"Martinez\u2010Lopez","sequence":"additional","affiliation":[{"name":"Department of Hematology Hospital Universitario 12 de Octubre, Universidad Complutense, CNIO  Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2018,1,25]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/trf.13069"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/trf.13789"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/trf.13474"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1158\/1078-0432.CCR-14-0695"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2015-10-646810"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1506348"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1152\/physrev.00035.2007"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/trf.13150"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/trf.13174"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2016-11-749432"}],"container-title":["Transfusion Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Ftme.12508","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/tme.12508","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,10]],"date-time":"2023-09-10T00:50:37Z","timestamp":1694307037000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/tme.12508"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,1,25]]},"references-count":10,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2019,6]]}},"alternative-id":["10.1111\/tme.12508"],"URL":"https:\/\/doi.org\/10.1111\/tme.12508","archive":["Portico"],"relation":{},"ISSN":["0958-7578","1365-3148"],"issn-type":[{"value":"0958-7578","type":"print"},{"value":"1365-3148","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,1,25]]},"assertion":[{"value":"2017-06-20","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2017-12-31","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2018-01-25","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}