{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T17:01:26Z","timestamp":1791478886414,"version":"4.3.4"},"reference-count":17,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2018,1,25]],"date-time":"2018-01-25T00:00:00Z","timestamp":1516838400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100015302","name":"Ortho Clinical Diagnostics","doi-asserted-by":"crossref","id":[{"id":"10.13039\/100015302","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Transfusion Medicine"],"published-print":{"date-parts":[[2019,6]]},"abstract":"<jats:title>SUMMARY<\/jats:title><jats:sec><jats:title>Objectives<\/jats:title><jats:p>To study the rate of ABO haemolytic anaemia of fetus and newborn (HDFN) in one institution over 6 years.<\/jats:p><\/jats:sec><jats:sec><jats:title>Background<\/jats:title><jats:p>ABO major incompatibility between mothers and their newborns occurs in about 10% of births. So, mothers with an O blood group may form IgG\u2010class antibodies against A and B antigens, which could pass across the placenta and lead to a variable degree of HDFN in the newborn.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>At our institution, we have reviewed data regarding ABO\u2010based HDFN in the last 6\u00a0years.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>We found that, in 28\u2009089 deliveries, an ABO major incompatibility between mothers and newborns occurs in 11% of cases, with 72% of O\/A and 28% of O\/B incompatibility. In turn, 23% of these newborns had an eluate\u2010confirmed positive direct antiglobulin test [DAT; 74% (511) were due to anti\u2010A and 26% (179) to anti\u2010B], with 1\u00b70% requiring invasive treatments (exchange transfusion or intravenous immunoglobulin). Overall, 2\u00b75% of the total newborns had a positive DAT for an anti\u2010A or anti\u2010B antibody, and 0\u00b711% required invasive treatment in addition to phototherapy for their HDFN.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Serological ABO HDFN is a relatively frequent event when an O\u2010A\/O\u2010B incompatibility between mothers and their newborn occurs and, in most cases, translates into a self\u2010limiting disease, with a small number of newborns requiring invasive treatments. The DAT test, although not predictive of disease severity, appears to be a useful tool to monitor babies born from O\u2010A\/O\u2010B\u2010incompatible pregnancies and to identify those who may require treatment.<\/jats:p><\/jats:sec>","DOI":"10.1111\/tme.12512","type":"journal-article","created":{"date-parts":[[2018,1,25]],"date-time":"2018-01-25T09:07:42Z","timestamp":1516871262000},"page":"197-201","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":31,"title":["Retrospective analysis of HDFN due to ABO incompatibility in a single institution over 6 years"],"prefix":"10.1111","volume":"29","author":[{"given":"A.","family":"Matteocci","sequence":"first","affiliation":[{"name":"Department of Transfusion Medicine and Stem Cell Unit San Camillo Forlanini Hospital  Rome Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"De Rosa","sequence":"additional","affiliation":[{"name":"Department of Transfusion Medicine and Stem Cell Unit San Camillo Forlanini Hospital  Rome Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"E.","family":"Buffone","sequence":"additional","affiliation":[{"name":"Department of Neonatology San Camillo Forlanini Hospital  Rome Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1715-3914","authenticated-orcid":false,"given":"L.","family":"Pierelli","sequence":"additional","affiliation":[{"name":"Department of Transfusion Medicine and Stem Cell Unit San Camillo Forlanini Hospital  Rome Italy"},{"name":"Department of Experimental Medicine Sapienza University  Rome Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2018,1,25]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pedneo.2015.11.006"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1651-2227.2009.01478.x"},{"key":"e_1_2_7_4_1","first-page":"518","article-title":"Survey on the prevention and incidence of haemolyticdisease of the newborn in Italy","volume":"11","author":"Bennardello F.","year":"2013","journal-title":"Blood Transfusion"},{"key":"e_1_2_7_5_1","first-page":"109","article-title":"Recommendations for the prevention and treatment of haemolytic disease of the fetus and newborn","volume":"13","author":"Bennardello F.","year":"2015","journal-title":"Blood 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survey of the current use of anti\u2010D immunoprophylaxis and the incidence of haemolyticdisease of the newborn in Italy","volume":"5","author":"Velati C.","year":"2007","journal-title":"Blood Transfusion"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-3148.2005.00549.x"}],"container-title":["Transfusion 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