{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,10]],"date-time":"2026-09-10T20:34:07Z","timestamp":1789072447391,"version":"build-2803163510"},"reference-count":25,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2018,2,19]],"date-time":"2018-02-19T00:00:00Z","timestamp":1518998400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Transfusion Medicine"],"published-print":{"date-parts":[[2018,8]]},"abstract":"<jats:title>SUMMARY<\/jats:title><jats:sec><jats:title>Aims\/Objectives<\/jats:title><jats:p>The aims of this study were to report a patient with acute haemolytic transfusion reaction (HTR) after transfusing uncross\u2010matched red blood cell (RBC) units and to identify the frequency of this complication.<\/jats:p><\/jats:sec><jats:sec><jats:title>Background<\/jats:title><jats:p>Uncross\u2010matched RBC units are commonly transfused in emergencies, but the frequency of acute HTR is unknown.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We describe a male stabbing victim who received three units of uncross\u2010matched RBC units complicated by acute intravascular HTR, disseminated intravascular coagulation (DIC) and renal failure. We identified 14 studies evaluating the frequency of acute HTR post\u2010emergency transfusion of uncross\u2010matched RBC units.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Acute HTR was shown by haemoglobinuria, free\u2010plasma haemoglobin and methemalbumin, with anti\u2010K and anti\u2010Fy<jats:sup>a<\/jats:sup> eluted from recipient red cells; acute DIC featured severe hypofibrinogenemia, thrombocytopenia, elevated fibrin D\u2010dimer and multiple bilateral renal infarcts. Two of the three transfused units reacted with pre\u2010existing RBC alloantibodies [anti\u2010K (titre, 128), anti\u2010Fy<jats:sup>a<\/jats:sup> (titre, 512)], explained by transfusion 25\u2009years earlier. Our literature review found the frequency of acute HTR following emergency transfusion of uncross\u2010matched RBC units to be 2\/3998 [0\u00b706% (95% CI, 0\u00b701\u20130\u00b721%)].<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Although emergency transfusion of uncross\u2010matched blood is commonly practiced at trauma centres worldwide, with low risk of acute HTR (&lt;1\/1000), our well\u2010documented patient case demonstrates the potential for acute HTR with severe complications.<\/jats:p><\/jats:sec>","DOI":"10.1111\/tme.12513","type":"journal-article","created":{"date-parts":[[2018,2,21]],"date-time":"2018-02-21T18:38:11Z","timestamp":1519238291000},"page":"319-325","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":17,"title":["Acute haemolysis, DIC and renal failure after transfusion of uncross\u2010matched blood during trauma resuscitation: illustrative case and literature review"],"prefix":"10.1111","volume":"28","author":[{"given":"J.","family":"Fiorellino","sequence":"first","affiliation":[{"name":"Department of Anesthesiology McMaster University  Hamilton Ontario Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A. L.","family":"Elahie","sequence":"additional","affiliation":[{"name":"Hamilton Regional Laboratory Medicine Program  Hamilton Ontario Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8046-7588","authenticated-orcid":false,"given":"T. E.","family":"Warkentin","sequence":"additional","affiliation":[{"name":"Hamilton Regional Laboratory Medicine Program  Hamilton Ontario Canada"},{"name":"Department of Pathology and Molecular Medicine McMaster University  Hamilton Ontario Canada"},{"name":"Department of Medicine McMaster University  Hamilton Ontario Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2018,2,19]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1503\/cjs.032009"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.3109\/10408367309151555"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.1968.03140210049012"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.1978.03290190035024"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1097\/ALN.0000000000000414"},{"key":"e_1_2_7_7_1","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1182\/blood.V9.2.103.103","article-title":"Some immunohematologic results of large transfusions of group O blood in recipients of other blood groups: a study of battle casualties in Korea","volume":"9","author":"Crosby W.H.","year":"1954","journal-title":"Blood"},{"key":"e_1_2_7_8_1","first-page":"201","volume-title":"Practical Haematology","author":"Dacie J.V.","year":"1995"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.ta.0000198373.97217.94"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1097\/00005373-198404000-00008"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1309\/AJCP9OFJN7FLTXDB"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0196-0644(87)80416-X"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/trf.12925"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1097\/TA.0b013e31823f0465"},{"key":"e_1_2_7_15_1","first-page":"515","volume-title":"Blood Transfusion in Clinical Medicine","author":"Mollison P.L.","year":"1987"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1537-2995.2012.03922.x"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1586\/17474086.1.1.99"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra1109343"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.21307\/immunohematology-2019-147"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/B978-0-7020-6696-2.00021-7"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1442-2026.2003.00442.x"},{"key":"e_1_2_7_22_1","first-page":"229","article-title":"Use of Rh positive blood in emergency situations","volume":"167","author":"Schmidt P.J.","year":"1988","journal-title":"Surgery, Gynecology & Obstetrics"},{"key":"e_1_2_7_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0196-0644(86)80609-6"},{"key":"e_1_2_7_24_1","doi-asserted-by":"publisher","DOI":"10.1097\/00005373-198610000-00006"},{"key":"e_1_2_7_25_1","doi-asserted-by":"publisher","DOI":"10.1111\/tme.12372"},{"key":"e_1_2_7_26_1","first-page":"284","article-title":"Blood antibodies and uncrossmatched type O blood","volume":"20","author":"Unkle D.","year":"1991","journal-title":"Heart and Lung"}],"container-title":["Transfusion Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Ftme.12513","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/tme.12513","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,18]],"date-time":"2023-09-18T11:18:17Z","timestamp":1695035897000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/tme.12513"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,2,19]]},"references-count":25,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2018,8]]}},"alternative-id":["10.1111\/tme.12513"],"URL":"https:\/\/doi.org\/10.1111\/tme.12513","archive":["Portico"],"relation":{},"ISSN":["0958-7578","1365-3148"],"issn-type":[{"value":"0958-7578","type":"print"},{"value":"1365-3148","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,2,19]]},"assertion":[{"value":"2017-10-16","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2018-01-18","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2018-02-19","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}