{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,18]],"date-time":"2026-09-18T02:08:17Z","timestamp":1789697297813,"version":"4.0.1"},"reference-count":14,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2018,5,21]],"date-time":"2018-05-21T00:00:00Z","timestamp":1526860800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100004836","name":"Det Frie Forskningsr\u00e5d","doi-asserted-by":"publisher","award":["09\u2010071231"],"award-info":[{"award-number":["09\u2010071231"]}],"id":[{"id":"10.13039\/501100004836","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Transfusion Medicine"],"published-print":{"date-parts":[[2018,10]]},"abstract":"<jats:title>SUMMARY<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>In patients undergoing open surgery for a ruptured abdominal aortic aneurysm (rAAA), survivors demonstrate a high platelet count, and proactive administration of platelets (and fresh frozen plasma) appears to influence mortality.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objectives<\/jats:title><jats:p>This trial investigated the effect of platelets administered before transport to surgery.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>In a prospective study design, patients were randomised to receive platelets (intervention; <jats:italic>n<\/jats:italic>\u2009=\u200961) or no platelets (control; <jats:italic>n<\/jats:italic>\u2009=\u200961) before transport to vascular surgery from 11 local hospitals. The study was terminated when one of the vascular surgical centres implemented endovascular repair for rAAA patients.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Thirty days after surgery, mortality was 36% for patients with intervention vs 31% for controls (<jats:italic>P<\/jats:italic>\u00a0=\u00a00\u00b732). Post\u2010operative thrombotic events (14 vs 15; <jats:italic>P<\/jats:italic>\u00a0=\u00a00\u00b769), renal failure (11 vs 10; <jats:italic>P<\/jats:italic>\u00a0=\u00a00\u00b715) and pulmonary insufficiency (34 vs 39; <jats:italic>P<\/jats:italic>\u00a0=\u00a00\u00b715) were similar in the two groups of patients. No adverse reactions to platelet administration were observed. In addition, length of stay in the intensive care unit was unaffected by intervention.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>For patients planned for open repair of a rAAA, we observed no significant effect of early administration of platelets with regard to post\u2010operative complications and stay in the ICU or in hospital and also no significant effect on mortality.<\/jats:p><\/jats:sec>","DOI":"10.1111\/tme.12540","type":"journal-article","created":{"date-parts":[[2018,5,21]],"date-time":"2018-05-21T10:32:17Z","timestamp":1526898737000},"page":"386-391","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Administration of platelets to ruptured abdominal aortic aneurysm patients before open surgery: a prospective, single\u2010blinded, randomised study"],"prefix":"10.1111","volume":"28","author":[{"given":"T. B.","family":"Lunen","sequence":"first","affiliation":[{"name":"Department of Anesthesiology, Rigshospitalet University of Copenhagen  Copenhagen Denmark"},{"name":"Department of Anesthesiology, SUH Zealand University Hospital Koege, Region Zealand  Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P. I.","family":"Johansson","sequence":"additional","affiliation":[{"name":"Department of Transfusion Medicine, Rigshospitalet University of Copenhagen  Copenhagen Denmark"},{"name":"Department of Surgery University of Texas Health Medical School  Houston Texas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L. P.","family":"Jensen","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology, SUH Zealand University Hospital Koege, Region Zealand  Denmark"},{"name":"Department of Vascular Surgery, Rigshospitalet University of Copenhagen  Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"K. M.","family":"Homburg","sequence":"additional","affiliation":[{"name":"Department of Clinical Immunology N\u00e6stved Sygehus  Naestved Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"O. C.","family":"Roeder","sequence":"additional","affiliation":[{"name":"Department of Vascular Surgery Odense University Hospital  Odense Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L.","family":"Lonn","sequence":"additional","affiliation":[{"name":"Department of Vascular Surgery, Rigshospitalet University of Copenhagen  Copenhagen Denmark"},{"name":"Department of Radiology, Rigshospitalet University of Copenhagen  Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"N. H.","family":"Secher","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology, Rigshospitalet University of Copenhagen  Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"U.","family":"Helgstrand","sequence":"additional","affiliation":[{"name":"Department of Vascular Surgery, Rigshospitalet University of Copenhagen  Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Carstensen","sequence":"additional","affiliation":[{"name":"Vascular Surgery, Region Zealand Slagelse Hospital  Slagelse Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"K. 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