{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,11]],"date-time":"2026-02-11T14:03:18Z","timestamp":1770818598452,"version":"3.50.1"},"reference-count":49,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2018,5,29]],"date-time":"2018-05-29T00:00:00Z","timestamp":1527552000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Transfusion Medicine"],"published-print":{"date-parts":[[2019,6]]},"abstract":"<jats:title>SUMMARY<\/jats:title><jats:p>Transfusion therapy is a common practice in the treatment of anaemia and can cause erythrocyte alloimmunisation. To systematise data related to erythrocyte alloimmunisation in patients with sickle cell disease (SCD), a bibliographic search was carried out in September 2017 to search for studies in four electronic databases. (i) Referring to the original work, (ii) being cohort or case\u2013control, (iii) having been developed with individuals with SCD and (iv) having evaluated the erythrocyte alloimmunisation. Two reviewers identified the articles for inclusion in the study, extracted the predetermined data and carried out the evaluation of the methodological quality of the work. 21 studies were selected; the studies included data on 20\u2009636 individuals (children and adults), were mostly published in the last 10\u00a0years, were developed in the United States and had high methodological quality. The occurrence of erythrocyte alloimmunisation ranged from 4\u00b74 to 76%, and there was a higher rate of alloimmunisation against antigens of the Rh system. The risk factors for alloimmunisation were age; gender (female); red blood cell (RBC) units received; presence of \u22651 autoantibodies, TNF\u2010\u03b1, interleukin (IL1B), human leukocyte antigens (HLA)\u2010DRB1 gene polymorphisms; first blood transfusion (BT) after 5\u00a0years of age, transfusion episodic, multiple or during inflammatory events, acute chest syndrome (ACS) and vase\u2010occlusive crisis (VOC); increased percentage of CD41 T memory cells; and positive direct antiglobulin test. Transfusion policies should be developed to protect the patient and his or her health based on the main factors associated with its incidence.<\/jats:p>","DOI":"10.1111\/tme.12543","type":"journal-article","created":{"date-parts":[[2018,5,30]],"date-time":"2018-05-30T05:29:15Z","timestamp":1527658155000},"page":"149-161","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":22,"title":["The erythrocyte alloimmunisation in patients with sickle cell anaemia: a systematic review"],"prefix":"10.1111","volume":"29","author":[{"given":"E. G.","family":"da Cunha Gomes","sequence":"first","affiliation":[{"name":"Professional Master's in Health, Laboratory Medicine and Forensic Technology Rio de Janeiro State University  Rio de Janeiro Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"L. A. F.","family":"Machado","sequence":"additional","affiliation":[{"name":"Professional Master's in Health, Laboratory Medicine and Forensic Technology Rio de Janeiro State University  Rio de Janeiro Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5052-1846","authenticated-orcid":false,"given":"L. C.","family":"de Oliveira","sequence":"additional","affiliation":[{"name":"Search Group NutriPali, Nutritionist Palliative Care Unit National Cancer Institute Jos\u00e9 Alencar Gomes da Silva  Rio de Janeiro Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J. F. N.","family":"Neto","sequence":"additional","affiliation":[{"name":"Lipids Laboratory\u2010LabLip, Faculty of Medical Sciences Rio de Janeiro State University  Rio de Janeiro Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2018,5,29]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/bjh.14609"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.3109\/03630269.2015.1077460"},{"key":"e_1_2_8_4_1","first-page":"559","article-title":"Red blood cell alloimmunisation in sickle cell disease in Eastern Province, Saudi Arabia","volume":"28","author":"Al\u2010Saeed A.H.","year":"1997","journal-title":"Medical Science Research"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.transci.2012.07.014"},{"key":"e_1_2_8_6_1","volume-title":"Technical Manual","author":"American Association of Blood Banks","year":"1999"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.26719\/2007.13.5.1181"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2013.10.010"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1537-2995.2002.00126.x"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2013-03-490623"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/bjh.14383"},{"key":"e_1_2_8_12_1","first-page":"68","article-title":"Alloimmunization is associated with older age of transfused red blood cells in sickle cell disease","volume":"28","author":"Desai P.C.","year":"2015","journal-title":"American Journal Hematology"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tracli.2013.04.111"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1111\/bjh.13123"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.lfs.2017.03.025"},{"key":"e_1_2_8_16_1","volume-title":"Fundamentos da Imuno\u2010Hematologia Eritrocit\u00e1ria","author":"Girello A.L.","year":"2011"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1590\/s1679-45082011ao2003"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pbio.1000238"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1111\/trf.13037"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.hemonc.2017.05.008"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.1111\/trf.13800"},{"key":"e_1_2_8_22_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1537-2995.2010.03045.x"},{"key":"e_1_2_8_23_1","doi-asserted-by":"crossref","first-page":"107","DOI":"10.3889\/oamjms.2017.054","article-title":"The impact of extended typing on Alloimmunization in transfused patients","volume":"5","author":"Makarovska\u2010Bojadzieva T.","year":"2017","journal-title":"Open Access Macedonian Journal of Medical Sciences"},{"key":"e_1_2_8_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bcmd.2017.01.014"},{"key":"e_1_2_8_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tracli.2008.10.002"},{"key":"e_1_2_8_26_1","doi-asserted-by":"publisher","DOI":"10.1111\/trf.12875"},{"key":"e_1_2_8_27_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1537-2995.2012.03796.x"},{"key":"e_1_2_8_28_1","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-151-4-200908180-00135"},{"key":"e_1_2_8_29_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1096-8652(199607)52:3<197::AID-AJH11>3.0.CO;2-D"},{"key":"e_1_2_8_30_1","doi-asserted-by":"publisher","DOI":"10.1590\/S0100-879X2005000500004"},{"key":"e_1_2_8_31_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1537-2995.2009.02435.x"},{"key":"e_1_2_8_32_1","first-page":"457","article-title":"Immunoregulatory networks in sickle cell alloimmunization","volume":"11","author":"Neurosci N.","year":"2016","journal-title":"Hematology American Society of Hematology Education Program"},{"issue":"4","key":"e_1_2_8_33_1","first-page":"CD002202","article-title":"Hydroxyurea (hydroxycarbamide) for sickle cell disease (review)","volume":"20","author":"Nevitt S.J.","year":"2017","journal-title":"Cochrane Database of Systematic Reviews"},{"key":"e_1_2_8_34_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajh.24188"},{"key":"e_1_2_8_35_1","first-page":"1526","article-title":"Alloimmunization in sickle cell anemia in the era of extended red cell typing","volume":"14","author":"O'Suoji C.","year":"2013","journal-title":"Pediatric Blood & Cancer"},{"key":"e_1_2_8_36_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2141.2001.02819.x"},{"key":"e_1_2_8_37_1","unstructured":"Padmanabhan S.&Chandrasekaran V.(2000)Incidence and significance of allo and auto antibodies in transfused adult sickle cell patients. 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