{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,6]],"date-time":"2026-06-06T14:50:51Z","timestamp":1780757451639,"version":"3.54.1"},"reference-count":37,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2018,8,24]],"date-time":"2018-08-24T00:00:00Z","timestamp":1535068800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100003593","name":"Conselho Nacional de Desenvolvimento Cient\u00edfico e Tecnol\u00f3gico","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003593","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002322","name":"Coordena\u00e7\u00e3o de Aperfei\u00e7oamento de Pessoal de N\u00edvel Superior","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100002322","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Transfusion Medicine"],"published-print":{"date-parts":[[2018,12]]},"abstract":"<jats:title>SUMMARY<\/jats:title><jats:sec><jats:title>Objectives<\/jats:title><jats:p>This study assessed the prevalence of visceral leishmaniasis in blood donors from three endemic regions in Brazil and evaluated the risk of transmission by transfusion.<\/jats:p><\/jats:sec><jats:sec><jats:title>Background<\/jats:title><jats:p>Despite strong evidence of the transmission of visceral leishmaniasis through blood transfusion, the real risk, an essential condition for taking effective measures to control this serious disease, has not been determined.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A multicentre study was performed in highly endemic areas. Candidates eligible for their first blood donation underwent a socio\u2010epidemiological interview, and blood samples were collected for enzyme\u2010linked immunosorbent assay (ELISA) analysis, Western blot and polymerase chain reaction (PCR). Patients transfused with red blood cells or random platelet concentrates collected from these donors were also studied. The results were analysed using descriptive statistics and prevalence estimates, with significance defined as p\u2010values &lt;0\u00b705.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Of the 608 eligible donors, 37 (6\u00b71%) were positive for visceral leishmaniasis as per ELISA. The socio\u2010epidemiological analysis showed a significantly higher prevalence in non\u2010Caucasians (p\u00a0=\u00a00\u00b7008). Among 296 patients who received blood components from these donors, the pre\u2010transfusion seropositivity was 7\u00b77%, and 13 patients received blood positive for <jats:italic>Leishmania infantum<\/jats:italic>. Six patients were followed up for 90\u2009days, of which two (33\u00b73%) had serological conversion at 60\u2009days.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>The results confirm the high prevalence of <jats:italic>L. infantum<\/jats:italic> seropositivity among donors in the three regions; the seroconversion in a short period of time in two of six patients suggests the possibility of transmission of the infection by transfusion.<\/jats:p><\/jats:sec>","DOI":"10.1111\/tme.12553","type":"journal-article","created":{"date-parts":[[2018,8,24]],"date-time":"2018-08-24T09:39:41Z","timestamp":1535103581000},"page":"433-439","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":19,"title":["Socio\u2010epidemiological characterisation of blood donors with asymptomatic <i>Leishmania infantum<\/i> infection from three Brazilian endemic regions and analysis of the transfusional transmission risk of visceral leishmaniasis"],"prefix":"10.1111","volume":"28","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8401-0147","authenticated-orcid":false,"given":"M. M.","family":"Ferreira\u2010Silva","sequence":"first","affiliation":[{"name":"Federal University of the Tri\u00e2ngulo Mineiro, MG  Uberaba Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L. A. S.","family":"Teixeira","sequence":"additional","affiliation":[{"name":"Federal University of the Tri\u00e2ngulo Mineiro, MG  Uberaba Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M. S.","family":"Tib\u00farcio","sequence":"additional","affiliation":[{"name":"Federal University of the Tri\u00e2ngulo Mineiro, MG  Uberaba Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G. A.","family":"Pereira","sequence":"additional","affiliation":[{"name":"Federal University of the Tri\u00e2ngulo Mineiro, MG  Uberaba Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"V.","family":"Rodrigues","sequence":"additional","affiliation":[{"name":"Federal University of the Tri\u00e2ngulo Mineiro, MG  Uberaba Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Palis","sequence":"additional","affiliation":[{"name":"Hemocenter Foundation of Piau\u00ed\u00a0\u2013\u00a0Hemopi  Teresina Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P.","family":"Afonso","sequence":"additional","affiliation":[{"name":"Hemocenter Foundation of Piau\u00ed\u00a0\u2013\u00a0Hemopi  Teresina Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Alves","sequence":"additional","affiliation":[{"name":"Hemocenter Foundation of Cear\u00e1\u2010 HEMOCE  Fortaleza Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J. 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G.","family":"Carvalho","sequence":"additional","affiliation":[{"name":"University of Montes Claros, MG  Montes Claros Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H.","family":"Moraes\u2010Souza","sequence":"additional","affiliation":[{"name":"Federal University of the Tri\u00e2ngulo Mineiro, MG  Uberaba Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2018,8,24]]},"reference":[{"key":"e_1_2_7_2_1","first-page":"379","article-title":"Cutaneous leishmaniasis, cutaneous glandular leishmaniasis, and transfusional kala\u2010azar","volume":"55","author":"Andre R.","year":"1958","journal-title":"Tropical Diseases Bulletin"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.transci.2017.09.007"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1086\/318476"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1537-2995.2006.00941.x"},{"key":"e_1_2_7_6_1","first-page":"732","article-title":"A case of kala azar caused by blood transfusion in an 8\u2010month old infant; 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